Association of Cystatin C with Leptin and TNF-α in Elderly Japanese Women

日本老年女性胱蛋白C與瘦體素及TNF-α的相關性

Ayaka Tsuboi ； Mika Takeuchi ； Mayu Terazawa-Watanabe ； Keisuke Fukuo ； Tsutomu Kazumi

《Asia Pacific Journal of Clinical Nutrition》 24卷4期 (2015/12) Pp. 626-632

https://doi.org/10.6133/apjcn.2015.24.4.18

摘要

背景與目的：胱蛋白C為一個老年死亡的新標記，其決定因子在亞洲老年族群尚未被大規模的探討。方法與研究設計：評估159名BMI平均值為22.6±2.9（SD）kg／m^2的日本社區老年女性，其胱蛋白C與體位測量值、心血管代謝、血液資料、營養狀況及發炎標記之相關。結果：血清肌酸酐與胱蛋白C平均值分別為0.73±0.16 mg/dL及0.85±0.20 mg/L。肌酸酐評估腎絲球過濾率（標準化迴歸係數-0.538，p＜0.001）、年齡（標準化迴歸係數0.274，p＜0.001）、血清瘦體素（標準化迴歸係數0.218，p＜0.001）及腫瘤壞死因子-α（TNF-α標準化迴歸係數0.165，p=0.0021）顯示為血清胱蛋白C的顯著預測因子，且此結果獨立於體脂肪百分比、胰島素抗性之恆定模式評估、高敏感度C反應蛋白、收縮壓及高密度脂蛋白膽固醇（累積R^2=0.674）。結論：社區老年女性血清瘦體素及TNF-α的增加導致胱蛋白C的提高，此相關獨立於腎功能、體脂質量、胰島素阻抗性及發炎反應。這個族群之胱蛋白C與死亡率的相關，可能是干擾因子造成的相關。

關鍵字

胱蛋白C ； 瘦體素 ； 腫瘤壞死因子－α ； 腎功能 ； 老人

並列摘要

Background and Objectives: Determinants of cystatin C, a novel marker of mortality in the elderly, have not been extensively studied in Asian elderly population. Methods and Study Design: Associations of cystatin C with anthropometric, cardiometabolic, hematological, nutritional variables and inflammatory markers were examined in 159 community-living elderly Japanese women whose BMI averaged 22.6±2.9 (SD) kg/m^2. Results: Serum creatinine and cystatin C averaged 0.73±0.16 mg/dL and 0.85±0.20 mg/L, respectively. Creatinine-based estimated glomerular filtration rate (standardized β, -0.538, p＜0.001), age (standardized β, 0.274, p＜0.001), serum leptin (standardized β, 0.218, p＜0.001) and tumour necrosis factor-α (TNF-α, standardized β, 0.165, p=0.002) emerged as significant predictors of serum cystatin C independent of percentage body fat, homeostasis model assessment of insulin resistance, high-sensitivity C-reactive protein, systolic blood pressure and HDL cholesterol (cumulative R^2=0.674). Conclusions: Elevated serum levels of leptin and TNF-α contributed to elevated cystatin C independent of kidney function, fat mass, insulin resistance and inflammation in community-living elderly women and may represent confounders of associations between cystatin C and mortality in this population.

並列關鍵字

cystatin C ； leptin ； TNF-α ； kidney function ； elderly