Coexistent Systemic Amyloidosis, Multiple Myeloma, and Refractory Anemia with Ringed Sideroblasts in a Previously Untreated Patient




Sangeeta Mehendale;Pritesh Patel;Valerie Lindgren;Damiano Rondelli;Sujata Gaitonde

Key Words

Myeloma ; Myelodysplastic syndrome ; De novo


International Journal of Case Reports and Images (IJCRI)

Volume or Term/Year and Month of Publication

2卷2期(2011 / 02 / 01)

Page #

1 - 4

Content Language


English Abstract

Introduction: We report the first case of coexistent systemic amyloidosis, plasma cell myeloma (MM), and myelodysplastic syndrome (refractory anemia with ringed sideroblasts:MDS-RARS). Case Report: Our patient was diagnosed with amyloidosis of the liver, stomach and tongue following which a bone marrow biopsy was performed. Review of the bone marrow biopsy revealed the presence of two distinct entities that have rarely been detected together; MM and MDS-RARS. There was no history of prior radiation or chemotherapy. Conclusion: Concurrent de novo disease processes involving both myeloid and lymphoid cell lines may not be as rare as they seem. Cytopenias in patients with MM must trigger a thorough investigation for an associated concurrent myeloid disorder. Presence of concurrent MDS would influence the choice of therapy and these patients need to be watched closely for progression of the myeloid disorder.

Topic Category 醫藥衛生 > 基礎醫學