Title

骨蝕寧對激素性股骨頭壞死家兔局部rBF、TNF及顯微結構的影響

Translated Titles

Effects of Gushining Decoction on rBF, TNF and Pathology in Rabbits with Steroid-induced Avascular Necrosis of Femoral Head

Authors

白良川(Liang-Chuan Bai);李保泉(Bao-Quan Li);丁鍔(E Ding);尹欣(Xin Yin);陳柯(Ke Chen)

Key Words

激素性股骨頭壞死 ; 骨蝕寧 ; 局部組織血流量 ; 腫瘤壞死因子 ; 病理組織學 ; Steroid-induced avascular necrosis of femoral head ; Gushining decoction ; Regional blood flow ; Tumor necrosis factor ; Histopathology

PublicationName

安徽中醫學院學報

Volume or Term/Year and Month of Publication

24卷6期(2005 / 12 / 01)

Page #

22 - 25

Content Language

簡體中文

Chinese Abstract

Objective: To observe effects of Gushining decoction on steroid-induced avascular necrosis of femoral head in rabbits, and to study further its mechanism. Method: Following the injection of large dosage of horse serum and methylprednisolonu, accumulation of lipid and necrosis of osteocytes in the femoral heads were seen in the model group of rabbits. Forty Chinese rabbits were employed and divided randomly into 4 groups, namely control group, model group, Xianling gubao group and Gushining group. The rBF and TNF were measured after 4 weeks, and also HE staining and pathological section were done in order to study the changes of histopathology under microscope. Result: Comparing with those in the control group, the rBF of the model group and Xianling gubao group decreased respectively while TNF increased (P<0.01), and also rate of empty lacuna in the femoral heads decreaced in the model group and Xianling gubao group (P<0.01), but both between the model group and Xianling gubao group had no difference (P>0.05). Impairment of bone trabeculae and bone cells induced by steroid was remarkably reduced in the Gushining group. Conclusion: Gushining decoction may treat disease of steroid-induced avascular necrosis of femoral head through improving microcirculationg of femoral head, reducing or restraining the inflame-mative cells, and protesting and promoting bone formation.

English Abstract

Objective: To observe effects of Gushining decoction on steroid-induced avascular necrosis of femoral head in rabbits, and to study further its mechanism. Method: Following the injection of large dosage of horse serum and methylprednisolonu, accumulation of lipid and necrosis of osteocytes in the femoral heads were seen in the model group of rabbits. Forty Chinese rabbits were employed and divided randomly into 4 groups, namely control group, model group, Xianling gubao group and Gushining group. The rBF and TNF were measured after 4 weeks, and also HE staining and pathological section were done in order to study the changes of histopathology under microscope. Result: Comparing with those in the control group, the rBF of the model group and Xianling gubao group decreased respectively while TNF increased (P<0.01), and also rate of empty lacuna in the femoral heads decreaced in the model group and Xianling gubao group (P<0.01), but both between the model group and Xianling gubao group had no difference (P>0.05). Impairment of bone trabeculae and bone cells induced by steroid was remarkably reduced in the Gushining group. Conclusion: Gushining decoction may treat disease of steroid-induced avascular necrosis of femoral head through improving microcirculationg of femoral head, reducing or restraining the inflame-mative cells, and protesting and promoting bone formation.

Topic Category 醫藥衛生 > 中醫藥學