Title

咪達普利對擴張型心肌病鈣電流的跨室壁不均一性的影響

Translated Titles

Effect of Imidapril on Transmural Variations of Calcium Current of Ventricular Myocytes in Rabbits with Dilated Cardiomyopathy

Authors

李泱(Yang Li);邱萍(Ping Qiu);王琳(Lin Wang);王士雯(Shi-Wen Wang);鍾江華(Jiang-Hua Zhong);張存泰(Cun-Tai Zhang);陸再英(Zai-Ying Lu)

Key Words

咪達普利 ; 心肌病 ; 充血性 ; 心肌 ; 鈣通道 ; 膜片鉗技術 ; 全細胞 ; imidapril ; cardiomyopathy ; congestive ; myocardium ; calcium channels ; patch clamp technique ; whole-cell

PublicationName

中國藥理學與毒理學雜誌

Volume or Term/Year and Month of Publication

18卷3期(2004 / 06 / 01)

Page #

194 - 198

Content Language

簡體中文

Chinese Abstract

AIM To explore the mechanism of imidapril inhibition on ventricular arrhythmia in patients with dilated cardiomyopathy (DCM). METHODS DCM model in rabbits was induced with doxotubicin, and imidapril 1.25 mg•kg^(-1). d^(-1) was orally administered for 8 weeks. Subendocardium (Endo), midmyocardium (M) and subepicardium (Epi) were isolated from the left ventricular free wall in rabbits. I(subscript Ca-L) was recorded with whole-cell patch clamp technique. RESULTS With the increment of cellular membrane capacitance in DCM cells, I(subscript Ca-L) densities decreased markedly. The average I(subscript Ca-L) densities of Epi, M and Endo in DCM cells were (6.7±1.0), (10.6±0.5) and (7.4±0.7) pA•pF^(-1). The difference of I(subscript Ca-L) densities from three layer cells was obviously increased. After treatment with imidapril, the I(subscript Ca-L) densities of Epi, M and Endo increased to (10.7±1.0), (12.7±0.6) and (11.1±1.6) pA•pF^(-1). Furthermore, the diversity of I(subscript Ca-L) densities of Epi, M and Endo was reduced. CONCLUSION Imidapril can decrease transmural variations of calcium current of ventricular in rabbits of DCM, which may be one of the mechanisms of antiarrhythmias.

English Abstract

AIM To explore the mechanism of imidapril inhibition on ventricular arrhythmia in patients with dilated cardiomyopathy (DCM). METHODS DCM model in rabbits was induced with doxotubicin, and imidapril 1.25 mg•kg^(-1). d^(-1) was orally administered for 8 weeks. Subendocardium (Endo), midmyocardium (M) and subepicardium (Epi) were isolated from the left ventricular free wall in rabbits. I(subscript Ca-L) was recorded with whole-cell patch clamp technique. RESULTS With the increment of cellular membrane capacitance in DCM cells, I(subscript Ca-L) densities decreased markedly. The average I(subscript Ca-L) densities of Epi, M and Endo in DCM cells were (6.7±1.0), (10.6±0.5) and (7.4±0.7) pA•pF^(-1). The difference of I(subscript Ca-L) densities from three layer cells was obviously increased. After treatment with imidapril, the I(subscript Ca-L) densities of Epi, M and Endo increased to (10.7±1.0), (12.7±0.6) and (11.1±1.6) pA•pF^(-1). Furthermore, the diversity of I(subscript Ca-L) densities of Epi, M and Endo was reduced. CONCLUSION Imidapril can decrease transmural variations of calcium current of ventricular in rabbits of DCM, which may be one of the mechanisms of antiarrhythmias.

Topic Category 醫藥衛生 > 藥理醫學