Translated Titles

Overexpression of PEMT2 Inhibits PI3K and Akt Expression in Rat CBRH-7919 Hepatoma Cells


李亞麗(Ya-Li Li);鄒偉(Wei Zou);馬克里(Ke-Li Ma);夏泉(Quan Xia);崔肇春(Zhao-Chun Cui)

Key Words

磷脂酰乙醇胺-N-甲基轉移酶2(PEMT2) ; 磷脂酰肌醇-3-激酶(PI3K) ; 蛋白激酶B(Akt) ; 肝癌 ; 凋亡 ; phosphatidylethanolamine N-methyltransferase-2 (PEMT2) ; phosphatidylinostal-3-kinase (PI3K) ; protein kinase B (Akt) ; hepatoma ; apoptosis



Volume or Term/Year and Month of Publication

31卷4期(2004 / 04 / 01)

Page #

345 - 349

Content Language


Chinese Abstract


English Abstract

In order to unravel the mechanism of inhibition of the cell proliferation induced by overexpression of PEMT2, the cell clone transfected with pemt2-cDNA was constructed and the effect of overexpression of PEMT2 on PI3K/Akt signaling pathway was investigated by the methods of RT-PCR, immunocytochemical and flow cytometry. The results show that the overexpression of PEMT2 could inhibit the expression of PI3K and Akt, and induce cell apoptosis. The results indicate that the down-regulating of PI3K/Akt signaling pathway could, at least partly, account for the inhibition of hepatoma cell proliferation induced by overexpression of PEMT2.

Topic Category 基礎與應用科學 > 物理
基礎與應用科學 > 化學
生物農學 > 生物科學