Title

(R, R)1-苄基-2,5-二氧-3,4-二羟基吡咯啉还原的研究

Translated Titles

Reduction of (R, R) 1-Benzyl-2, 5-Dioxo-3, 4-Dihydroxy-Pyrrolidine and a Study on the Reaction Mechanism

Authors

丁绍民(Shao-Min Ding);王玉生(Yu-Sheng Wang);宋华付(Hua-Fu Song);陈玉岩(Yu-Yan Chen);程传杰(Chuan-Jie Cheng)

Key Words

酰亚胺 ; 还原 ; 叔胺 ; imide ; reduction ; tertiary-amide

PublicationName

北京理工大學學報

Volume or Term/Year and Month of Publication

24卷10期(2004 / 10 / 01)

Page #

917 - 919

Content Language

簡體中文

Chinese Abstract

在氢气的保护下,用LiAlH4还原体系在35℃,用NaBH4/BF3,NaBH4/I2还原体系在0℃,分别对酰亚胺(R,R)1-苄基-2,5-二氧3,4-二羟基吡咯啉进行还原,得到相应的叔胺(S,S)1-苄基-3,4-二羟基吡咯啉,测量了产物的熔点,并用红外图谱表征了叔胺的结构,产率分别为66%,58%和63%。最后对硼烷和LiAlH4还原酰亚胺可能的机理进行了讨论。

English Abstract

Imide (R, R) 1-benzyl-2, 5 dioxo-3, 4-dihydroxy-pyrrolidine was reduced by NaBH4/I2, NaBH4/BF3 under argon atmosphere at 0℃, and by LiAlH4 under argon atmosphere at 35℃ separately. Thus the corresponding tertiary amide (S, S) 1-benzyl-3, 4-dihydroxy-pyrrolidine was produced, and the yield was 63%, 58% and 66%. The melting point of each product was measured and the structure characterized by infrared spectroscopy. The reduction mechanism of diborane and LiAlH4 was finally discussed.

Topic Category 基礎與應用科學 > 基礎與應用科學綜合
工程學 > 工程學綜合