Title

N-甲基-2-吡咯腈的合成改进

Translated Titles

Improved Synthesis of N-methyl-2-pyrrolecarbonitrile

Authors

梁志宏(Zhi-Hong Liang);赵林(Lin Zhao);马步伟(Bu-Wei Ma);赵振新(Zhen-Xin Zhao);原思国(Si-Guo Yuan)

Key Words

吡咯腈 ; N-甲基吡咯 ; 合成 ; pyrrolecarbonitrile ; N-methylpyrrole ; sysnthesis

PublicationName

信陽師範學院學報(自然科學版)

Volume or Term/Year and Month of Publication

18卷2期(2005 / 04 / 10)

Page #

192 - 194

Content Language

簡體中文

Chinese Abstract

以N-甲基吡咯(NMP)为起始原料,先与Vilsmeier试剂反应,经碳酸钠水解、二氯乙烷萃取制得N-甲基-2-吡咯醛(NMPA),此法溶剂回收利用率高、安全、易于工业化生产并降低了生产及污水处理费用。再以NMPA与盐酸羟胺经肟化制得N-甲基-2-吡咯肟(NMPAO),最后在醋酐中脱水制得N-甲基-吡咯腈(NMPC)。在由NMPAO脱水制NMPC的过程后,经氢氧化钠水溶液中和,降低了体系的色度,萃取易于进行,产品收率74.7%。

English Abstract

N-methyl-2-pyrrolealdehyde was synthesized by the reaction of N-methylpyrrole with Vilsmerier reagent and by hydrolysis in Na2CO3 solution subsequently. Owing to Na2CO3 and dichloroethane instead of CH3COONa and ether, the reformative process has effective solvent recovery and high security. After then, N-methyl-2-pyrrolecarbonitrile (MPC) was synthesized by oximation and dehydration of N-methyl-2-pyrrolealdehyde in hydroxylamined hydrochloride and acetic anhydride respectively. By neutralization of reaction system with NaOH solution, its colourity was decreased, the following extraction operation was convenient, and the yield of MPC is 74.7%.

Topic Category 基礎與應用科學 > 基礎與應用科學綜合
工程學 > 工程學綜合