胃肠富集kruppel因子GKLF在宫颈鳞癌中的表达及意义

Expression of GKLF/KLF4 in Squamous Crevical Carcinoma and Its Significance

刘红(Hong Liu)；崔竹梅(Zhu-Mei Cui)；齐卫红(Wei-Hong Qi)；徐冰(Bing Xu)

宫颈癌 ； 胃肠富集kruppel因子 ； CKLF ； 细胞增殖 ； 细胞分化 ； cervical carcinoma ； Gut-enriched Kruppel like fator GKLF ； cell proliferation ； cell differentiation

泰山醫學院學報

25卷5期（2004 / 10 / 25）

425 - 428

簡體中文

Objective: To investigate the expression of Gut-enriched kruppel like factor (GKLF/KLF4) mRNA and its significance in squamous cervical carcinoma and normal cervical epithelial tissues. Methods we compared GKLF expression in 32 cases of squamous cervical carcinoma to 10 cases of normal cervical epithelial tissues, utilizing semi-quantitative Reverse transcript-polymerase chain reaction (RT-PCR). Results The expression of GKLF mRNA in endometrial carcinoma is 0.42±0.19, while that is 0.76±0.15 in normal endometrium. Decreased expression of GKLF mRNA was served in endometrial carcinoma patients compared to normal endometrial tissues, the difference is obviously (P＜0.05). Furthermore, the expression of GKLF mRNA decreased with the clinical stage from 0 to Ⅳ, the difference was obviously (P＜0. 05). With the increasing of the pathologic grade from 1 to 3, decreased expression of GKLF mRNA was observed in endometrial carcinoma patients, the difference was obviously (P＜0.05). Conclusion Decreased expression of GKLF in quamous cervical carcinoma and oppositely related to the pathologic grade and the clinical stage. suggest that GKLF may contributed to the development of cervical carcinoma.

Objective: To investigate the expression of Gut-enriched kruppel like factor (GKLF/KLF4) mRNA and its significance in squamous cervical carcinoma and normal cervical epithelial tissues. Methods we compared GKLF expression in 32 cases of squamous cervical carcinoma to 10 cases of normal cervical epithelial tissues, utilizing semi-quantitative Reverse transcript-polymerase chain reaction (RT-PCR). Results The expression of GKLF mRNA in endometrial carcinoma is 0.42±0.19, while that is 0.76±0.15 in normal endometrium. Decreased expression of GKLF mRNA was served in endometrial carcinoma patients compared to normal endometrial tissues, the difference is obviously (P＜0.05). Furthermore, the expression of GKLF mRNA decreased with the clinical stage from 0 to Ⅳ, the difference was obviously (P＜0. 05). With the increasing of the pathologic grade from 1 to 3, decreased expression of GKLF mRNA was observed in endometrial carcinoma patients, the difference was obviously (P＜0.05). Conclusion Decreased expression of GKLF in quamous cervical carcinoma and oppositely related to the pathologic grade and the clinical stage. suggest that GKLF may contributed to the development of cervical carcinoma.