白细胞介素18与心绞痛患者左室射血分数的相关性研究

The Research of Correlation of Interleukin-18 with Angina Pectoris Patients' Left Ventricular Ejection Fraction

张燕(Yan Zhang)；黎莉(Li Li)；张运(Yun Zhang)；朱圆圆(Yuan-Yuan Zhu)；王颖(Ying Wang)；谭红伟(Hong-Wei Tan)

内科学 ； 白细胞介素18 ； 心绞痛 ； 动脉粥样硬化 ； 左室射血分数 ； Angina pectoris ； Interleukin-18 ； Arteriosclerosis ； Left ventricular ejection fraction LVEF

泰山醫學院學報

25卷5期（2004 / 10 / 25）

436 - 438

簡體中文

Aim To detect the peripheral venous blood' concentration of IL-18 in patients with UA and SA and evaluate it's correlation with angina pectoris patients' left ventricular ejection fraction. Methods Eighty hosipitalized patients were enrolled in this research since 2002.12 to 2004.01. Forty cases were UA, twenty cases were SA, twenty cases were normal controls. All patients were performed coronary artery angiography and Doppler echocardiography. IL-18 was measured with ELISA methods. Results The concentrations of IL-18 in UA and SA were much higher than controls', but there were no difference between these two. Patients with LVEF＜50% had higher IL-18 concentrations than those with LVEF＞50%. Conclusion IL-18 was positive correlated to coronary artery diseases, but no prediction to the stability of AS plaques. And it was nagtive correlated to Left ventricular ejection fraction (LVEF). So IL-18 had important values in prodiction of angina pectoris.

Aim To detect the peripheral venous blood' concentration of IL-18 in patients with UA and SA and evaluate it's correlation with angina pectoris patients' left ventricular ejection fraction. Methods Eighty hosipitalized patients were enrolled in this research since 2002.12 to 2004.01. Forty cases were UA, twenty cases were SA, twenty cases were normal controls. All patients were performed coronary artery angiography and Doppler echocardiography. IL-18 was measured with ELISA methods. Results The concentrations of IL-18 in UA and SA were much higher than controls', but there were no difference between these two. Patients with LVEF＜50% had higher IL-18 concentrations than those with LVEF＞50%. Conclusion IL-18 was positive correlated to coronary artery diseases, but no prediction to the stability of AS plaques. And it was nagtive correlated to Left ventricular ejection fraction (LVEF). So IL-18 had important values in prodiction of angina pectoris.