Title

单核细胞趋化蛋白-1在急性胰腺炎肺损害中的作用

Translated Titles

Role of Monocyte Chemotactic Protein-1 in Acute Lung Injury during Acute Pancreatitis

Authors

徐岷(Min Xu);周国雄(Guo-Xiong Zhou);张弘(Hong Zhang);黄介飞(Jie-Fei Huang);魏群(Qun Wei);肖明兵(Ming-Bing Xiao);江枫(Feng Jiang)

Key Words

胰腺炎 ; 单核细胞趋化蛋白-1 MCP-1 ; 急性肺损害ALI ; pancreatitis ; monocyte chemotactic protein-1 MCP-1 ; acute lung injury ALI

PublicationName

中國現代醫學雜誌

Volume or Term/Year and Month of Publication

15卷22期(2005 / 11 / 30)

Page #

3428 - 3431

Content Language

簡體中文

Chinese Abstract

[Objective] To investigate the role of Monocyte chemotactic protein-1 (MCP-1) in the pathogenesis of acute lung injury (ALI) during acute pancreatitis (AP). [Methods] AP model was induced by intraperitoneal injection of cerulein or retrograde infusion of 5% sodium taurocholate into the bili-pancreatic duct in SD rats. Eighty-four SD rats were randomly divided into four groups: cerulein group, saline control group, sodium taurocholate group and operational control group. Expression of pulmonary MCP-1 protein and MCP-1 mRNA were detected by immunohistochemistry and semi-quantitative reverse transcriptase polymerase chain reaction (RT-PCR) at different time point in every group, respectively. [Results] No significant difference was found between cerulein group and saline control group at different time point. Expression of pulmonary MCP-1 proteins and MCP-1 mRNA in sodium taurocholate group 6 hours after operation were significantly higher than those of operational control group (P<0.01). Expression of MCP-1 was gradually up-regulated and correlated with the histological change of lung. [Conclusions] MCP-1 may play an important role in the pathogenesis of ALI during AP.

English Abstract

[Objective] To investigate the role of Monocyte chemotactic protein-1 (MCP-1) in the pathogenesis of acute lung injury (ALI) during acute pancreatitis (AP). [Methods] AP model was induced by intraperitoneal injection of cerulein or retrograde infusion of 5% sodium taurocholate into the bili-pancreatic duct in SD rats. Eighty-four SD rats were randomly divided into four groups: cerulein group, saline control group, sodium taurocholate group and operational control group. Expression of pulmonary MCP-1 protein and MCP-1 mRNA were detected by immunohistochemistry and semi-quantitative reverse transcriptase polymerase chain reaction (RT-PCR) at different time point in every group, respectively. [Results] No significant difference was found between cerulein group and saline control group at different time point. Expression of pulmonary MCP-1 proteins and MCP-1 mRNA in sodium taurocholate group 6 hours after operation were significantly higher than those of operational control group (P<0.01). Expression of MCP-1 was gradually up-regulated and correlated with the histological change of lung. [Conclusions] MCP-1 may play an important role in the pathogenesis of ALI during AP.

Topic Category 醫藥衛生 > 醫藥衛生綜合
醫藥衛生 > 預防保健與衛生學
醫藥衛生 > 藥理醫學
醫藥衛生 > 社會醫學