Title

AT1R基因多態性與原發性高血壓合併腦血管病的相關性研究

Translated Titles

Correlations of AT1R Gene Polymorphism to Cerebrovascular Diseases in Essential Hypertensive Patients

Authors

石靜萍(Jing-Ping Shi);張穎冬(Ying-Dong Zhang);許利剛(Li-Gang Xu);葛劍青(Jian-Qing Ge);錢敏(Min Qian)

Key Words

血管緊張素Ⅱ受體 ; 基因 ; 原發性高血壓 ; 腦血管病 ; angiotensin Ⅱ receptor ; gene ; essential hypertension ; cerebrovascular diseases

PublicationName

南京醫科大學學報(自然科學版)

Volume or Term/Year and Month of Publication

24卷5期(2004 / 09 / 05)

Page #

487 - 490

Content Language

簡體中文

Chinese Abstract

Objective: To investigate the association of angiotensin II type I receptor (AT1R) gene polymorphism with cerebrovascular diseases in essential hypertensive patients. Methods: Forty-five essential hypertensive patients without complication of cerebrovascular diseases (EH), 33 EH patients with cerebral hemorrhage (EH-CH), 73 EH patients with cerebral infarction (EH-CI), 60 healthy controls were genotyped for the A1166C variation at the 3'-untranslated region of AT1R gene by PCR/Dde I restriction endonuclease digestion. Results: ① For A1166C locus of AT1R gene, distributions of genotypes frequencies of ER and ER-CR group were significantly different from healthy controls (P < 0.05). The frequencies of C in ER and EH-CH group were significantly higher than those in healthy controls (0.29 vs 0.17, P<0.05; 0.33 vs 0.17, P<0.01 respectively), but there was no significant difference in the frequencies of genotypes and C allele between ER and ER-CR group. ② No significant differences were found in the frequencies of genotypes and C allele as comparing ER, healthy controls with ER-CI group. ③ Logistic regression analysis showed the polymorphism of AT1R gene was one of the independent risk factors for EH (P<0.05, OR=0.44), but not for EH-CH. The correlative analysis showed a positive correlation between the polymorphisms of AT1R gene and systolic blood pressure as well as diastolic blood pressure in patients with essential hypertension complicated with cerebrovascular diseases (r=0.23 and 0.25 respectiveres, P<0.05). Conclusion: By increasing blood pressure, the A1166C allele of AT1R gene may contribute to the occurrence of EH-CH.

English Abstract

Objective: To investigate the association of angiotensin II type I receptor (AT1R) gene polymorphism with cerebrovascular diseases in essential hypertensive patients. Methods: Forty-five essential hypertensive patients without complication of cerebrovascular diseases (EH), 33 EH patients with cerebral hemorrhage (EH-CH), 73 EH patients with cerebral infarction (EH-CI), 60 healthy controls were genotyped for the A1166C variation at the 3'-untranslated region of AT1R gene by PCR/Dde I restriction endonuclease digestion. Results: ① For A1166C locus of AT1R gene, distributions of genotypes frequencies of ER and ER-CR group were significantly different from healthy controls (P < 0.05). The frequencies of C in ER and EH-CH group were significantly higher than those in healthy controls (0.29 vs 0.17, P<0.05; 0.33 vs 0.17, P<0.01 respectively), but there was no significant difference in the frequencies of genotypes and C allele between ER and ER-CR group. ② No significant differences were found in the frequencies of genotypes and C allele as comparing ER, healthy controls with ER-CI group. ③ Logistic regression analysis showed the polymorphism of AT1R gene was one of the independent risk factors for EH (P<0.05, OR=0.44), but not for EH-CH. The correlative analysis showed a positive correlation between the polymorphisms of AT1R gene and systolic blood pressure as well as diastolic blood pressure in patients with essential hypertension complicated with cerebrovascular diseases (r=0.23 and 0.25 respectiveres, P<0.05). Conclusion: By increasing blood pressure, the A1166C allele of AT1R gene may contribute to the occurrence of EH-CH.

Topic Category 醫藥衛生 > 醫藥衛生綜合
醫藥衛生 > 藥理醫學