Title

擴張型心肌病心肌組織中組織蛋白酶L與心功能的關係

Translated Titles

Relationship between Cathepsin L and Dilated Cardiomyopathy

Authors

張新剛(Xin-Gang Zhang);于小華(Xiao-Hua Yu);王時俊(Shi-Jun Wang);李雙傑;李高平;陳瑞珍;楊英珍

Key Words

組織蛋白酶L ; 擴張型心肌病 ; 心肌 ; Cathepsin L ; Dilated cardiomyopathy ; Myocardium

PublicationName

中國臨床醫學

Volume or Term/Year and Month of Publication

12卷4期(2005 / 08 / 25)

Page #

566 - 568

Content Language

簡體中文

Chinese Abstract

Objective: To clarify the relationship between lysosomal protease cathepsin L and dilated cardiomyopathy (DCM). Methods: Myocardial tissue specimens of 20 patients who underwent orthotopic cardiac transplantation were collected as subjects. 5 normal myocardium samples of patients from sudden death were collected at autopsy as controls. In those myocardium, cathepsin L was detected by immunohistochemistry and RT-PCR, respectively. At the same time, the relationship between the levels of cathepsin L mRNA expression and myocardial function (ejection fraction, EF) was investigated. Results: The expression levels of cathepsin L mRNA and protein in DCM group were remarkably elevated compared with those in the control group, and the expression of cathepsin L mRNA was significantly negatively correlated with myocardial function (ejection fraction, EF). Conclusion: Cathepsin L probably plays a role in the pathogenesis of DCM.

English Abstract

Objective: To clarify the relationship between lysosomal protease cathepsin L and dilated cardiomyopathy (DCM). Methods: Myocardial tissue specimens of 20 patients who underwent orthotopic cardiac transplantation were collected as subjects. 5 normal myocardium samples of patients from sudden death were collected at autopsy as controls. In those myocardium, cathepsin L was detected by immunohistochemistry and RT-PCR, respectively. At the same time, the relationship between the levels of cathepsin L mRNA expression and myocardial function (ejection fraction, EF) was investigated. Results: The expression levels of cathepsin L mRNA and protein in DCM group were remarkably elevated compared with those in the control group, and the expression of cathepsin L mRNA was significantly negatively correlated with myocardial function (ejection fraction, EF). Conclusion: Cathepsin L probably plays a role in the pathogenesis of DCM.

Topic Category 醫藥衛生 > 醫藥衛生綜合