Translated Titles

Effect of Zinc on Human Prostatic Carcinoma Cell Growth


徐志兵(Zhi-Bing Xu);王國民(Guo-Min Wang);張永康(Yong-Kang Zhang);孫立安;金泰廙

Key Words

鋅 ; 前列腺癌 ; 增殖 ; Zinc ; Prostatic carcinoma ; Growth



Volume or Term/Year and Month of Publication

12卷4期(2005 / 08 / 25)

Page #

636 - 638

Content Language


Chinese Abstract


English Abstract

Objective: To evaluate the effect of zinc on human proatatic carcinoma (PCa) cell growth. Methods: Growth inhibition and various regulatory responses were investigated in three human prostatic carcinoma cell lines (DU-145, PC-3 and LNCaP), treated with various concentrations of zinc. Results: Incubation of the PCa cell lines with different levels of zinc resulted in inhibition of cell growth, a lower 50% inhibition of cell growth (IC50) value for zinc(about 100 ng/ml)was detected in LNCaP cells, which were androgen dependent, whereas androgen independent PC-3 and DU-145 cells exhibited a higher IC50 for zinc (about 780 ng/ml and 810 ng/ml). Incubation with 1 000 ng/ ml zinc resulted in maximum inhibition of growth in both cell lines. Cell flow cytometric analyses revealed that the cell growth inhibitions were accompanied by an increase in apoptosis. Conclusion: These results suggest that zinc inhibits human prostatic carcinoma cell growth, possibly due to induction of cell apoptosis.

Topic Category 醫藥衛生 > 醫藥衛生綜合