Effect of Zinc on Human Prostatic Carcinoma Cell Growth
徐志兵(Zhi-Bing Xu)；王國民(Guo-Min Wang)；張永康(Yong-Kang Zhang)；孫立安；金泰廙
鋅 ； 前列腺癌 ； 增殖 ； Zinc ； Prostatic carcinoma ； Growth
|Volume or Term/Year and Month of Publication||
12卷4期（2005 / 08 / 25）
636 - 638
Objective: To evaluate the effect of zinc on human proatatic carcinoma (PCa) cell growth. Methods: Growth inhibition and various regulatory responses were investigated in three human prostatic carcinoma cell lines (DU-145, PC-3 and LNCaP), treated with various concentrations of zinc. Results: Incubation of the PCa cell lines with different levels of zinc resulted in inhibition of cell growth, a lower 50% inhibition of cell growth (IC50) value for zinc(about 100 ng/ml)was detected in LNCaP cells, which were androgen dependent, whereas androgen independent PC-3 and DU-145 cells exhibited a higher IC50 for zinc (about 780 ng/ml and 810 ng/ml). Incubation with 1 000 ng/ ml zinc resulted in maximum inhibition of growth in both cell lines. Cell flow cytometric analyses revealed that the cell growth inhibitions were accompanied by an increase in apoptosis. Conclusion: These results suggest that zinc inhibits human prostatic carcinoma cell growth, possibly due to induction of cell apoptosis.