Title

輸尿管癌單純手術與術後輔助放療的對照分析

Translated Titles

Validity of Postoperative Radiotherapy in Transitional Cell Carcinoma of the Upper Urinary Tract

Authors

陳兵(Bing Chen);王國民(Guo-Ming Wang);張立(Li Zhang);曾昭衝

Key Words

輸尿管腫瘤 ; 放療 ; 生存分析 ; Ureteral neoplasms ; Radiotherapy ; Survival rates

PublicationName

中國臨床醫學

Volume or Term/Year and Month of Publication

12卷4期(2005 / 08 / 25)

Page #

641 - 643

Content Language

簡體中文

Chinese Abstract

Objective: To evaluate the role of postoperative adjuvant radiation therapy in transitional cell carcinoma of the upper urinary tract. Methods: We retrospectively reviewed a series of 46 patients between February, 1998 and June, 2004. Twenty four patients underwent surgery followed by radiation therapy to a total dose of 50 Gy/25Fx, only to the tumor bed in 9 patients, to the tumor bed and its regional nodes and bladder in 15 patients. Results: After a mean followup of 46 months, 7 in 9 patients who treated only to the tumor bed and 3 in 15 patients who underwent surgery followed by radiation therapy to the renal bed/ureteral bed/bladder experienced locoregional failure (78% vs 20%, P=0.005). And 12 in 22 patients without adjuvant radiotherapy experienced locoregional failure (55% vs 20%, P=0.036). Five-years overall survival rates with or without adjuvant radiotherapy were 52.54% and 26.64%, P=0.431. Conclusion: Our series suggests that the patients suffered with transitional cell carcinoma of the upper urinary tract need a postoperative radiation therapy, the radiotherapy should be treated to the renal bed/ureteral bed/bladder.

English Abstract

Objective: To evaluate the role of postoperative adjuvant radiation therapy in transitional cell carcinoma of the upper urinary tract. Methods: We retrospectively reviewed a series of 46 patients between February, 1998 and June, 2004. Twenty four patients underwent surgery followed by radiation therapy to a total dose of 50 Gy/25Fx, only to the tumor bed in 9 patients, to the tumor bed and its regional nodes and bladder in 15 patients. Results: After a mean followup of 46 months, 7 in 9 patients who treated only to the tumor bed and 3 in 15 patients who underwent surgery followed by radiation therapy to the renal bed/ureteral bed/bladder experienced locoregional failure (78% vs 20%, P=0.005). And 12 in 22 patients without adjuvant radiotherapy experienced locoregional failure (55% vs 20%, P=0.036). Five-years overall survival rates with or without adjuvant radiotherapy were 52.54% and 26.64%, P=0.431. Conclusion: Our series suggests that the patients suffered with transitional cell carcinoma of the upper urinary tract need a postoperative radiation therapy, the radiotherapy should be treated to the renal bed/ureteral bed/bladder.

Topic Category 醫藥衛生 > 醫藥衛生綜合