Title

阿奇黴素與頭孢克肟治療小兒細菌性腹瀉病療效比較

Translated Titles

Comparison of Azithromycin versus Cefixime for Treatment of Bacterial Diarrhea in Children

Authors

王希華(Xi-Hua Wang);周莎(Sha Zhou);蔡虹蔚(Hong-Wei Cai)

Key Words

阿奇黴素 ; 頭孢克肟 ; 細菌性腹瀉病 ; 兒童 ; Azithromycin ; Cefixime ; Bacterial diarrhea ; Children

PublicationName

中國臨床醫學

Volume or Term/Year and Month of Publication

12卷4期(2005 / 08 / 25)

Page #

724 - 725

Content Language

簡體中文

Chinese Abstract

Objective: To evaluate and compare the efficacy of azithromycin and cefixime in the treatment of acute bacterial invasive diarrhea in children. Methods: From Jul. 2004 to Nov. 2004, 121 evaluable children, ages 4 months to 12 years old presenting with acute bacterial diarrhea were randomized to receive either azithromycin (10 mg/kg/day, once a day; n=64) or cefixime (5~8 mg/kg/day, twice a day; n=57). Clinical response were assessed on days 3. Results: Clinical cure or improvement was observed in 98.44% and 96.49% of the azithromycin and cefixime groups, respectively. There was no significant difference between two groups (χ^2=0.472, P>0.05). Conclusion: Oral azithromycin was safe and effective for the empiric treatment of acute invasive diarrhea in pediatric patients.

English Abstract

Objective: To evaluate and compare the efficacy of azithromycin and cefixime in the treatment of acute bacterial invasive diarrhea in children. Methods: From Jul. 2004 to Nov. 2004, 121 evaluable children, ages 4 months to 12 years old presenting with acute bacterial diarrhea were randomized to receive either azithromycin (10 mg/kg/day, once a day; n=64) or cefixime (5~8 mg/kg/day, twice a day; n=57). Clinical response were assessed on days 3. Results: Clinical cure or improvement was observed in 98.44% and 96.49% of the azithromycin and cefixime groups, respectively. There was no significant difference between two groups (χ^2=0.472, P>0.05). Conclusion: Oral azithromycin was safe and effective for the empiric treatment of acute invasive diarrhea in pediatric patients.

Topic Category 醫藥衛生 > 醫藥衛生綜合