Title

巴曲酶對缺血再灌注後凋亡相關基因時效研究

Translated Titles

Relationship between Time and Effect of Batroxobin on Apoptosis-related Gene after Cerebral Ischemia/Reperfusion in Gerbils

Authors

龔潔(Jie Gong);丁新生(Xin-Sheng Ding);印衛兵(Wei-Bing Yin);馮美江;高陽;李娟;高飛

Key Words

沙土鼠 ; 巴曲酶 ; 凋亡 ; Bcl-2基因 ; Bax基因 ; Gerbils ; Batroxobin ; Apoptosis ; Bcl-2 gene ; Sax gene

PublicationName

中國臨床醫學

Volume or Term/Year and Month of Publication

12卷4期(2005 / 08 / 25)

Page #

726 - 728

Content Language

簡體中文

Chinese Abstract

Objective: To discuss the effect and possible mechanism of Batroxobin on expression of apoptosis related gene Bcl-2 and Bax in hippocampal CA1 region after cerebral ischemia in gerbils. Methods1 Gerbils were treated with Batroxobin injection through abdominal after cerebral ischemia/reperfusion (I/R) and then immunohistochemistry was used to detect the expression of Bcl-2 and Bax in neuron of hippocampal CA1 region. Results: Compared with the control group, the expression of Bcl-2 in hippocampal CA1 region increased obviously, while the expression of Bax in treated group decreased, The best effects were seen from 6 hours before I/R to 6 hours after I/R Conclusion: Batroxobin injection may reduce the apoptosis of neuron after I/R through enhancing the expression of Bcl-2 and inhibiting the expression of Bax. The effect of Batroxobin injection on cerebral I/R was time dependent.

English Abstract

Objective: To discuss the effect and possible mechanism of Batroxobin on expression of apoptosis related gene Bcl-2 and Bax in hippocampal CA1 region after cerebral ischemia in gerbils. Methods1 Gerbils were treated with Batroxobin injection through abdominal after cerebral ischemia/reperfusion (I/R) and then immunohistochemistry was used to detect the expression of Bcl-2 and Bax in neuron of hippocampal CA1 region. Results: Compared with the control group, the expression of Bcl-2 in hippocampal CA1 region increased obviously, while the expression of Bax in treated group decreased, The best effects were seen from 6 hours before I/R to 6 hours after I/R Conclusion: Batroxobin injection may reduce the apoptosis of neuron after I/R through enhancing the expression of Bcl-2 and inhibiting the expression of Bax. The effect of Batroxobin injection on cerebral I/R was time dependent.

Topic Category 醫藥衛生 > 醫藥衛生綜合