Title

Ⅲ期NSCLC化疗加前程累及野后程适形放疗的临床研究

Translated Titles

Clinical Trial of pre-course Involved Field and Late Course Conformal Radiation Therapy Combined with Chemotherapy for Ⅲ non-small Cell Lung Cancer

Authors

肖宝荣(Bao-Rong Xiao);李瑞卿(Rui-Qing Li);丁继强(Ji-Qiang Ding);周长杰(Chang-Jie Zhou);郑珊红(Shan-Hong Zheng);翟西菊(Xi-Ju Zhai)

Key Words

癌,非小细胞肺/放射疗法 ; 癌,非小细胞肺/药物疗法 ; 存活率 ; 肺肿瘤/放射疗法 ; 肺肿瘤/药物疗法 ; carcinoma, non-small cell lung/radiotherapy ; carcinoma, non-small cell lung/drug therapy ; survival rate ; lung neoplasms/radiotherapy ; lung neoplasms/drug therapy

PublicationName

中華腫瘤防治雜誌

Volume or Term/Year and Month of Publication

12卷13期(2005 / 07 / 14)

Page #

1010 - 1012

Content Language

簡體中文

Chinese Abstract

目的:观察前程累及野后程适形放疗联合健择/去甲长春花碱加顺铂(GP/NP)方案化疗治疗Ⅲ期非小细胞肺癌(non-small cell lung cancer, NSCLC)的疗效。方法:64例NSCLC前瞻性随机分成对照组和试验组,各32例,均同时放、化疗。对照组用EP方案化疗(依托泊苷100mg/平方公尺,d1~d3;顺铂30nag/平方公尺,d1~d3),21d为1个周期,放疗采用常规外照射,D(下标 T) 2Gy/次,每周5次,总D(下标 T) 50~60Gy。试验组用GP/NP方案化疗(健择1000mg/平方公尺,d1、d8;去甲长春花碱25mg/平方公尺,d1、d8;顺铂30mg/平方公尺,d1~d3),21d为1个周期,放疗采用前程累及野后程适形放疗,D(下标 T) 1.8~2.0Gy/次,每周5次,总D(下标 T) 55~64Gy。结果:对照组总有效率56.3%(18/32),试验组总有效率87.5%(28/32),1、2年生存率分别为37.5%(12/32)、21.9%(7/32)和71.9%(23/32)、46.9%(15/32),差异有统计学意义,χ^2=4.62,P=0.030。结论:前程累及野后程适形放疗联合GP/NP方案化疗治疗Ⅲ期NSCLC有较好疗效,其远期疗效须进一步观察。

English Abstract

OBJECTIVE: To evaluate the effect of pre-course involved field and late course conformal radiation therapy combined with GP/NP chemothempy on stage Ⅲ non-small cell lung carcinoma (NSCLC). METHODS: 64 NSCLC patients were randomizedly divided into control group and experimental group. All patients received radiotherapy plus concurrent chemotherapy. The patients in control group received chemotherapy with Vp-16 (100mg/m^2, d1-d3) and DDP (30 mg/m^2, d1-d3), with one cycle lasting 21 days. Radiotherapy was given with conventional fraction in 2 Gy per fraction and five fractions per week. The total tumor doses were 50-60 Gy. The patients in experimental group received chemotherapy with GEM (1000mg/m^2, d1, d8)/NVB (25mg/m^2, d1, d8)and DDP (30mg/m^2, d1-d3), with one cycle lasting 21 days. Radiotherapy was given with pre-course involved field and late course conformal radiation therapy in 1.8-2Gy per fraction and five fractions per week. The total tumor doses were 55-64Gy. RESULTS: The overall response rate was 56.3% in control group and 87.5% in experimental group. The 1-, 2-year survival rates were 37.5%, 21.9% and 71.9%, 46.9% in control group and in experimental group(χ^2=4.62, P=0.030). CONCLUSIONS: Pre-course involved field and late course conformal radiation therapy combined with GP/NP chemothempy on stage Ⅲ non-small cell lung carcinoma is better than conventional radiotherapy, Long term results need further follow-up.

Topic Category 醫藥衛生 > 內科