經低溫電漿電化學改質鈦金屬表面之特性分析

良好生物相容性是植體的首要要求，而植體材料的本質及其表面特質決定其生物相容性，尤其是與宿主組織直接接觸的材料表面。雖然目前對於植體表面與組織之間的反應、其長期穩定性及在臨床上的顯著性仍無定論，但已知植入後最早的生物反應為組織液蛋白質在植體表面的吸附，這層緊密吸附的蛋白質直接決定接下來宿主對植體表面的細胞反應，所以為了提昇植體與組織間整合，可藉由控制介面反應，吸附特定蛋白質，進而導引有利之組織癒合。本研究利用低溫電漿來活化鈦金屬表面以進一步連接白蛋白，企圖改變鈦金屬表面化學性質，發展一種能鍵結已知生物活性分子到鈦金屬表面的技術。首先鈦金屬圓片以氫氣電漿去除表面污染物，來產生可重複取得的清潔表面，接著用丙烯胺電漿處理，使丙烯腰聚合在鈦金屬表面，再以交鍵劑戊二醛將白蛋白與丙烯胺的胺基(-NH2)鍵結。研究顯示使用電漿處理技術可使鈦金屬表面胺基化，加上交鏈劑戊二醛的處理後，可使鈦金屬表面接上白蛋白產生表面改質，確可提供一個鍵結已知生物活性分子到鈦金屬表面的方式，以期植體植入後能引導及促進組織復原。

關鍵字

鈦金屬；低溫電漿；交鏈劑；白蛋白

並列摘要

Biocompatibility is the prime requisite for implant material and is determined by the bulk properties and especially the surfaces of implant which directly contacting the host tissue. Even though the relationships and reactions between the surface of implant and tissue and their long-term integrity and clinical efficacy are still not well understood, the first biological reaction known to occur after implantation of a biomaterial is the adsorption of tissue fluid proteins onto its surface and these tightly bound proteins strongly influence the subsequent interactions of cells with the surface. In order to optimize the integration of implants, it is desirable to control interfacial reactions such that nonspecific adsorption of proteins is minimized and beneficial molecules are selectively adsorbed onto biomaterials prior to their implantation. In this regard, our goal was to develop a glow-discharge method to functionalize titanium surfaces by the covalent immobilization of bioactive organic molecules. Based on the above investigation, the surface characteristics was successful modified on the titanium plates by glow discharge technology and this method could offer the possibility of covalently linking selected molecules onto titanium surface in order to guide and promote the tissue healing that occurs during implant integration in bone and soft tissue.

並列關鍵字

titanium ； glow discharge ； cross-linking agent ； albumin

國際替代計量

經低溫電漿電化學改質鈦金屬表面之特性分析

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