Role of Protease Inhibitors in Acute Pancreatitis

以蛋白酶抑制劑治療急性胰臟炎的結果仍有極大的爭議。雖然在這種特殊的治療模式上已經有相當多的研究，但是，早期的研究仍未能提供一個結論。急性胰臟炎發作後，伴隨而來的全身系統性發炎反應在其病態生理上扮演了重要角色。在眾多發炎因子之中，蛋白酶－抗蛋白酶的平衡失調在人類的急性胰臟炎的進行中是一個重要的引發因子。作者以及其他的研究者近來的臨床以及基礎的研究，結果呈現小分子量的蛋白酶抑制劑對於治療急性胰臟炎（尤其是嚴重型）有其一定的效果。新的治療模式已經為了此一臨床上十分棘手的疾病打開了一個新的道路，但是要完全闡明蛋白酶抑制劑的功效仍需投入更多的研究心力努力才行。

關鍵字

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並列摘要

The results of treatment with protease inhibitors for acute pancreatitis are conflicting. Although much work has focused on this special treatment modality, early investigations were not conclusive. The systemic inflammatory response that follows acute pancreatitis is a major concern in its pathophysiology. Among numerous candidate molecules, protease-protease inhibitor imbalance in the progression of acute pancreatitis is considered important in the trigger events within the human body. Recent work by the authors and other investigators has shown that small molecular-weight protease inhibitors are effective in the treatment of acute pancreatitis in the laboratory and in the clinical setting, especially in severe cases with organ dysfunctions. The new treatment protocols have opened a way to understanding the very aspects of the mechanism that underlies this complex disease. More work, however, is still needed for the complete elucidation of the effects of protease inhibitors in acute pancreatitis.

並列關鍵字

acute pancreatitis ； gabexate mesilate ； multiple organ dysfunction syndrome ； protease inhibitor ； sepsis ； systemic inflammatory response syndrome

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Role of Protease Inhibitors in Acute Pancreatitis

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