This retrospective study compares the outcome of 40 infected hips treated with a two-stage reimplantation surgery with an interim antibiotic-loaded cement spacer to that of 40 infected hips treated without a spacer. The control of infection, restoration of function, and surgical complications were assessed. Recurrence of infection was noted in 2 (5%) hips treated with an interim spacer and 3 (7.5%) hips treated without a spacer. Thirty-one (77.5%) patients who had a spacer could walk with various aids while only 7 (17.5%) patients treated without a spacer remained ambulatory in the interim period. On performing the second-stage surgery, the operative time was shorter and the estimated blood was less when a spacer was previously used. Complications associated with the use of a spacer included a fracture of the spacer in 3 hips, and dislocation of the spacer prosthesis in 3 hips. Eight (20%) hips treated without a spacer had dislocations following reimplantation while only one (2.5%) dislocation was encountered in hips that were treated with a spacer before revision. We concluded that two-stage reimplantation is an excellent method to eradicate hip infection. The use of a temporary cement spacer was associated with better ambulatory function between stages, an easier revision surgery, and a lower dislocation rate following reimplantation.