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糖尿病患者血液中三價鉻與葡萄糖及脂質濃度之相關性

Correlation Between Blood Chromium (III) Level, Blood Glucose and Lipid Concentrations in Diabetes

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摘要


This study investigated the correlation between blood chromium (III) concentrations n normal, mild hyperglycemia and severe hyperglycemia for hemoglobin A1c (HbA1c), serum insulin and serum lipid concentrations. Eighty-four elderly subjects (aged 40~70 years; 41 male and 43 female) were divided into three groups: severe hyperglycemia group (fasting glucose > 8.3 mol/L, n = 38), mild hyperglycemia group (fasting glucose = 7.0~8.3 mol/L, n = 24) and normal group (fasting glucose < 7.0 mol/L, n = 24). The fasting glucose, postprandial glucose and hemoglobin A1c concentrations were higher ( p < 0.05) in the mild hyperglycemia group and severe hyperglycemia group than the normal group. The blood chromium (III) concentration was lower ( p < 0.05) in the severe hyperglycemia group and mild hyperglycemia group than the normal group. Triglyceride concentration, ratios of total cholesterol to HDL-cholesterol and LDL-cholesterol to HDL-cholesterol were higher in the severe hyperglycemia group and mild hyperglycemia group than the normal group. There was s significant negative correlation (r = -0.9931; -0.9529) between blood chromium level and fasting glucose or fasting insulin concentration. There was a significant negative correlation (r = -0.8504; -0.9894) between blood chromium level and LDL-cholesterol or triglyceride concentration. These results suggest that the blood chromium (III) concentration decreased with increasing blood glucose concentration and serum lipids in diabetes.

關鍵字

三價鉻 血糖濃度 糖尿病

並列摘要


This study investigated the correlation between blood chromium (III) concentrations n normal, mild hyperglycemia and severe hyperglycemia for hemoglobin A1c (HbA1c), serum insulin and serum lipid concentrations. Eighty-four elderly subjects (aged 40~70 years; 41 male and 43 female) were divided into three groups: severe hyperglycemia group (fasting glucose > 8.3 mol/L, n = 38), mild hyperglycemia group (fasting glucose = 7.0~8.3 mol/L, n = 24) and normal group (fasting glucose < 7.0 mol/L, n = 24). The fasting glucose, postprandial glucose and hemoglobin A1c concentrations were higher ( p < 0.05) in the mild hyperglycemia group and severe hyperglycemia group than the normal group. The blood chromium (III) concentration was lower ( p < 0.05) in the severe hyperglycemia group and mild hyperglycemia group than the normal group. Triglyceride concentration, ratios of total cholesterol to HDL-cholesterol and LDL-cholesterol to HDL-cholesterol were higher in the severe hyperglycemia group and mild hyperglycemia group than the normal group. There was s significant negative correlation (r = -0.9931; -0.9529) between blood chromium level and fasting glucose or fasting insulin concentration. There was a significant negative correlation (r = -0.8504; -0.9894) between blood chromium level and LDL-cholesterol or triglyceride concentration. These results suggest that the blood chromium (III) concentration decreased with increasing blood glucose concentration and serum lipids in diabetes.

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