The Effects of Chlorella on Lipid Metabolism in Rats Fed with High Fat and High Cholesterol Diet
楊素卿(Suh-Ching Yang)；黃娣儀(Ti-l Huang)；黃啟彰(Chi-Chang Huang)；謝明哲(Ming-Jer Shieh)；邱琬淳(Wan-Chun Chiu)；鄭建睿(Chien-Jui Cheng)；陳俊榮(Jiun-Rong Chen)
綠藻 ； 高脂血症 ； 血脂質 ； chlorella ； hyperlipidemia ； plasma lipid profile
|Volume or Term/Year and Month of Publication||
26卷1期（2001 / 03 / 01）
22 - 31
The purpose of this study was to investigate the effects of chlorella on the lipid metabolism of rats fed with a high fat and high cholesterol diet. Forty Wistar rats were divided into five groups (control, AD0, AD1, AD5 and AD10). In the control group, rats were fed normal diets (5% soybean oil). In the AD0, AD1, AD5 and AD10 groups, rats were fed with high fat and high cholesterol diets (15% soybean oil and 1% cholesterol) containing 0%, 1%, 5% and 10% chlorella, respectively. The experimental period was 8 weeks. The results showed that the total plasma cholesterol (TC) and low density lipoprotein-cholesterol(LDL-C) levels were significantly lower in the AD1 group at weeks 4, 6 and 8, and in the AD10 group at weeks 6 than in the AD0 group. Furthermore, triglyceride (TG) levels were significantly lower in the AD1, AD5 and AD10 than in AD0 group throughout the experimental period. The high density lipoprotein-cholesterol (HDL-C) levels were significantly higher in the AD1, AD5 and AD10 groups than in the AD0 group. When compared to the AD0 group, the liver TC content in the AD1, AD5 and AD10 groups were significantly decreased by 30%、68%、77%, and the TG levels were decreased by 50%、67%、68%, respectively. However, the fecal cholesterol and bile acid levels were significantly decreased in the AD1 and AD10 groups than in the AD0 and AD5groups.