Title

綠藻對於餵食高油脂高膽固醇飼料之大白鼠脂質代謝的影響

Translated Titles

The Effects of Chlorella on Lipid Metabolism in Rats Fed with High Fat and High Cholesterol Diet

DOI

10.6691/JCNS.200103_26(1).0003

Authors

楊素卿(Suh-Ching Yang);黃娣儀(Ti-l Huang);黃啟彰(Chi-Chang Huang);謝明哲(Ming-Jer Shieh);邱琬淳(Wan-Chun Chiu);鄭建睿(Chien-Jui Cheng);陳俊榮(Jiun-Rong Chen)

Key Words

綠藻 ; 高脂血症 ; 血脂質 ; chlorella ; hyperlipidemia ; plasma lipid profile

PublicationName

中華民國營養學會雜誌

Volume or Term/Year and Month of Publication

26卷1期(2001 / 03 / 01)

Page #

22 - 31

Content Language

繁體中文

Chinese Abstract

本實驗之目的在探討高油脂、高膽固醇飲食條件下綠藻對大白鼠體內脂質代謝的影響。將40隻Wistar系大白鼠分為對照組、AD0、AD1、AD5以及AD10等5組。以正常飼料(大豆油5%)飼養對照組,而以高油脂(大豆油15%)、高膽固醇(膽固醇1%)同時添加0%、1%、5%或10%綠藻粉之飼料飼養AD0、AD1、AD5以及AD10組。實驗期為八週。結果顯示:在TC和LDL-C濃度方面與AD0組比較之下,AD1組在第4、6、8週時顯著較低,而AD10組在第6週時顯著較低。在TG濃度方面與AD0組比較之下AD1、AD5和AD10組在第2、4、6、8週時皆明顯較低。在HDL-C濃度方面與AD0組比較之下AD1、AD5和AD10組在第2、4、6、8週時皆明顯較高。另外,肝中的TC與AD0組比較之下,AD1、AD5、AD10組各降低30%、68%、77%,而肝中的TG與AD0組比較之下,各綠藻添加組則各降低50%、67%、68%。與AD0組比較時,AD1以及AD10組之糞便膽固醇量和膽酸量則明顯降低。

English Abstract

The purpose of this study was to investigate the effects of chlorella on the lipid metabolism of rats fed with a high fat and high cholesterol diet. Forty Wistar rats were divided into five groups (control, AD0, AD1, AD5 and AD10). In the control group, rats were fed normal diets (5% soybean oil). In the AD0, AD1, AD5 and AD10 groups, rats were fed with high fat and high cholesterol diets (15% soybean oil and 1% cholesterol) containing 0%, 1%, 5% and 10% chlorella, respectively. The experimental period was 8 weeks. The results showed that the total plasma cholesterol (TC) and low density lipoprotein-cholesterol(LDL-C) levels were significantly lower in the AD1 group at weeks 4, 6 and 8, and in the AD10 group at weeks 6 than in the AD0 group. Furthermore, triglyceride (TG) levels were significantly lower in the AD1, AD5 and AD10 than in AD0 group throughout the experimental period. The high density lipoprotein-cholesterol (HDL-C) levels were significantly higher in the AD1, AD5 and AD10 groups than in the AD0 group. When compared to the AD0 group, the liver TC content in the AD1, AD5 and AD10 groups were significantly decreased by 30%、68%、77%, and the TG levels were decreased by 50%、67%、68%, respectively. However, the fecal cholesterol and bile acid levels were significantly decreased in the AD1 and AD10 groups than in the AD0 and AD5groups.

Topic Category 醫藥衛生 > 預防保健與衛生學
Times Cited
  1. 戴碧真(2012)。脆江蘺鮮萃品及乾燥品在高脂肪誘導 倉鼠肥胖模式中降低血脂及體脂形成。中山醫學大學生化暨生物科技研究所學位論文。2012。1-68。 
  2. 劉正儀(2004)。綠藻對BALB/c小鼠全身性及腸道免疫之影響。臺北醫學大學醫學科學研究所學位論文。2004。1-91。
  3. 賴亭安(2011)。以複方食材改善內臟油脂形成與改善代謝症候群。中原大學生物科技研究所學位論文。2011。1-87。
  4. 賴瑩潔(2014)。配方食品改善不同肥胖體型的體脂肪指標之效應。中原大學生物科技研究所學位論文。2014。1-161。