Effects of Angiotensin Ⅱ on the Proliferation and Fibronectin Production of Glomerular Mesangial Cells

Translated Titles



陳鴻鈞(Hung-Chun Chen);莊玄昇(Hsuan-Sheng Chuang);謝明家(Min-Chia Hsieh);譚棉心(Mian-Shin Tan);顧進裕(Jinn-Yuh Guh);許芸婷(Yung-Ting Hsu);辛錫璋(Shyi-Jang Shin)

Key Words

血管收縮素Ⅱ ; 腎絲球環間質細胞 ; 纖維蛋白元 ; angiotensin Ⅱ ; mesangial cell ; fibronectin


Acta Nephrologica

Volume or Term/Year and Month of Publication

18卷2期(2004 / 05 / 25)

Page #

57 - 61

Content Language


Chinese Abstract


English Abstract

Angiotensin Ⅱ (Ang-Ⅱ) is a potent vasoactive hormone which plays an important role in the pathogenesis of glomereulosclerosis. Since glomerulosclerosis is characterized by alterations in both cellularities and the extracellular matrix, we investigate the effects of Ang-Ⅱ on the cellular proliferation and fibronectin production of glomerular mesangial cells. Fibronectin was measured by Western blot analysis and fibronectin mRNA was measured by Northern blot analysis. The results were as follows: (1) Ang-Ⅱ increased [3H]-thymidine uptake of mesangial cells in a dose-dependent manner. (2) Ang-Ⅱ increased the number of mesangial cells in a time-dependent manner. (3) Ang-Ⅱ enhanced fibronectin mRNA expression and its production of mesangial cells in a time-dependent manner. Our results indicate that Ang-Ⅱ is an active stimulant for the proliferation and fibronectin production of glomerular mesangial cells.

Topic Category 醫藥衛生 > 內科