Prostatic Pure Small Cell Carcinoma v.s. Mixed-Type Small Cell Carcinoma: Analysis of Two Cases

單純型及混合型前列腺小細胞癌之兩病例分析

許智凱(Chih-Kai Hsu) ； 鄭建睿(Chien-Jui Cheng) ； 陳冠州(Kuan-Chou Chen) ； 江漢聲(Han-Sun Chiang) ； 朱娟秀(Jan-Show Chu)

《臺灣泌尿科醫學會雜誌》 16卷3期 (2005/09) Pp. 115-119

摘要

前列腺小細胞癌爲少見的前列腺惡性腫瘤．我們整理分析近年來本院的兩個病例。第一位病人爲單一細胞型態的單純小細胞癌，診斷時已合併多重器官之轉移，第二位病人則是混合型的小細胞癌。兩病例病理切片組織免疫特殊染色皆呈現chromogranin A，synaptophysin，and cytokeratins陽性，及陰性的PSA染色。第一例在經尿道前列腺切除手術做出診斷後給予gemcitabine及carboplatin的複合性化學治療及放射治療，其骨骼轉移病灶得到部分改善。第二例則是在姑息性經尿道前列腺切除手術後給予體外放射線治療。

關鍵字

攝護腺 ； 小細胞癌 ； 神經內分泌 ； 組織免疫染色

並列摘要

We analyzed 2 cases of small cell carcinoma of the prostate. One patient had pure small cell carcinoma with multiple organ metastasis, while the other had a mixed-type carcinoma. The immunohistochemical studies revealed positive reactions to chromogranin A, synaptophysin, and cytokeratin stains, and negative for PSA stain over both small cell carcinoma foci. These 2 patients were immediately treated, and partial resolution of the previous metastatic bone lesions was noted after receiving 5 courses of chemotherapy with the combination of gemcitabine, carboplatin, and irradiation therapy in case 1, while adjuvant irradiation was scheduled for case 2.

並列關鍵字

prostate ； small cell carcinoma ； neuroendocrine ； immunohistochemical studies