2001～2003年台灣登革熱／登革出血熱的流行病學探討

Epidemiology of Dengue Fever/Dengue Hemorrhagic Fever in Taiwan, 2001~2003

吳民惠(Min-Huei Wu) ； 黃高彬(Kao-Pin Hwang) ； 蔡季君(Jih-Jin Tasi) ； 吳宗樹(Tsung-Shu Wu) ； 黃彥彰(Yen-Chang Huang) ； 金傳春(Chwan-Chuen King)

《台灣公共衛生雜誌》 24卷5期 (2005/10) Pp. 452-459

https://doi.org/10.6288/TJPH2005-24-05-09

摘要

Objective: The largest epidemic of dengue hemorrhagic fever (DHF) caused by dengue virus serotype 2 (DEN-2) since 1942 occurred in 2002. The purpose of this study is to determinate the important epidemiological characteristics of DHF in 2002~2003. Methods: Epidemiological and serological data were collected by field investigations and defined by scholars. Results: (1) the percentage of DHF cases in 2002 significantly increased from 27th~35th week [5.74% (99/1626)] to the 36th~44th week [7.77% (199/2361)] and 45th~2003 1st week [10.18% (103/909)] (p＜0.000l); (2) DHF cases occurred more frequently in patients with underlying diseases; and (3) DHF had significant associations with the patient's self-described past dengue history (p=0.005) but smaller-scale serological data did not (p=0.08). Conclusions: The rapid infection of large human populations might increase the dimension of virus variability and allow the virus to have a higher epidemic potential. Future studies on pathogenesis of DHF are needed to emphasize the interactions between virus evolution and alternating hosts through transmission chains.

關鍵字

登革熱 ； 登革出血熱 ； 流行病學 ； 血清流行病學 ； 流行潛力

並列摘要

Objective: The largest epidemic of dengue hemorrhagic fever (DHF) caused by dengue virus serotype 2 (DEN-2) since 1942 occurred in 2002. The purpose of this study is to determinate the important epidemiological characteristics of DHF in 2002~2003. Methods: Epidemiological and serological data were collected by field investigations and defined by scholars. Results: (1) the percentage of DHF cases in 2002 significantly increased from 27th~35th week [5.74% (99/1626)] to the 36th~44th week [7.77% (199/2361)] and 45th~2003 1st week [10.18% (103/909)] (p＜0.000l); (2) DHF cases occurred more frequently in patients with underlying diseases; and (3) DHF had significant associations with the patient's self-described past dengue history (p=0.005) but smaller-scale serological data did not (p=0.08). Conclusions: The rapid infection of large human populations might increase the dimension of virus variability and allow the virus to have a higher epidemic potential. Future studies on pathogenesis of DHF are needed to emphasize the interactions between virus evolution and alternating hosts through transmission chains.

並列關鍵字

dengue fever DF ； dengue hemorrhagic fever DHF ； epidemiology ； serology ； epidemic potential

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