Radiotherapy of Conjunctival Lymphoma with A Specially Designed Lens Block

結膜淋巴瘤之放射治療：特殊設計之水晶體合金模塊

許維中(Wei-Chung Hsu) ； 丁禮莉(Lai-Lei Ting) ； 鄭秀成(Shiu-Chen Jeng) ； 王博民(Po-Ming Wang) ； 雷德(Louis Lui Tak) ； 陳斯榮(Szu-Jong Chen) ； 鍾娜娜(Na-Na Chung) ； 林高德(Gau-De Lin)

《放射治療與腫瘤學》 7卷3期 (2000/09) Pp. 161-168

https://doi.org/10.6316/TRO/200007(3)161

摘要

目的：評估並討論結膜淋巴瘤放射治療之成果和技術。
材料與方法：此回溯性研究乃針對自1988年至1996年，10位在台大醫院接受放射治療之結膜淋巴瘤患者。其中8位男性，2位女性，年齡自32歲至75歲，平均年齡為59.1歲。多數病患以結膜腫塊、眼睛發紅及異物感為臨床表現。病患之結膜病灶均以單一前方照野包含整個結膜組織來治療，電子能量由3MeV至10MeV不等。放射治療總劑量30 Gy到50 Gy ，分15至 25次給予，治療時間間距為23至33天。所有病患均使用特殊設計之合金模塊以保護水晶體。追蹤時間達24至124個月。
結果：所有病患在追蹤時間內均無局部或轉移病灶。而放射治療的併發症，包含視力下降、白內障及畏光均屬輕微。
結論：以總劑量30Gy至40Gy的放射治療可有效用在局限於結膜的淋巴瘤患者。藉由熟練的治療技術及良好保護具高放射線敏感度的水晶體可降低放射治療的副作用。

關鍵字

結膜淋巴瘤,惡性腫瘤,放射治療,水晶體

並列摘要

Purpose:To evaluate and discuss the therapeutic results and technique of conjunctival lymphoma.
Materials and Methods: This retrospective study was to review the 10 patients with conjunctival lymphoma treated at National Taiwan University Hospital from 1988 to 1996. There were 8 men and 2 women. The range of age was 32 - 75 years old, mean: 59.1 years old. Most of the patients presented with conjunctival mass, reddish eyes and forelgn body sensation. The conjunctival lesions in all patients were treated with a single anterior field which covered the entire conjunctiva, using 3 MeV to 10 MeV electron beam. Total dose of 30 Gy to 50 Gy was delivered in 15 to 25 fractions over 23 to 33 days. In all cases, a specially designed lead shield was used to protect the lens. The follow-up time ranged from 24 months to 124 months.
Results: All patients were doing well with no sign of active localized or distant disease till the closing date of the study. Moreover, the complications, including decreased visual acuity, cataract and photophobia, were minimal.
Conclusion: Lymphoma clinically localized to conjunctiva as the initial presentation can be cured by radiation therapy with a dosage of 30 Gy to 40 Gy. The complications of radiation therapy can be minimized with sophisticated treatment technique and well protection of the highly radiosensitive lens.

並列關鍵字

Conjunctival lymphoma,neoplasm,radiotherapy,lens