- 期刊
Adenoid Cystic Carcinoma of the Trachea Treated with Post-operative Chemoradiotherapy and Metronomic Chemotherapy: A Case Report
術後同步化學放射治療及節拍式化學治療用於氣管腺樣囊狀癌之治療：病例報告
摘要
氣管腺樣囊狀癌為一種罕見疾病，其治療是以手術為主。我們報告一位氣管腺樣囊狀癌的40歲男性病患，經手術、同步化學放射治療（總劑量為64.8Gy，以36分次給予，同時給予每週Cisplatin 30mg/平方公尺）及輔助化學治療（每月給予5-Fluorouracil及Cisplatin）後，短期內卻發現有局部復發及肺部轉移的情形。經肺轉移切除後，開始了以Etoposide及cisplatin為基礎的搶救性化學療法。但是經過3次搶救性化學療法後，疾病依舊持續進展。值得注意的是，稍後卻發現腫瘤對以口服Etoposide及Cisplatin為基礎的節拍式化學治療有良好的反應，且負作用亦不大。在這篇報告中，我們發現對於放射線及化學治療反應不佳的轉移性氣管腺樣囊狀癌，節拍式化學治療或許是一個選擇。
並列摘要
Adenoid cystic carcinoma (ACC) of the trachea is a rare disease and primarily treated with surgery. Here we report a 40 years-old male patient with ACC of the trachea. He was initially treated with surgery, concurrent chemoradiotherapy (delivered with a total dose of 64.8 Gy in 36 fractions concurrently with weekly cisplatin 30 mg/m^2) and adjuvant chemotherapy (monthly 5-fluorouracil and cisplatin). However, local recurrence and lung metastasis developed within a short period. After pulmonary metastatectomy, salvage chemotherapy with etoposide and cisplatin for 3 cycles were given but the disease kept progressing. Intriguingly, metronomic chemotherapy with oral etoposide and cyclophosphamide showed a good tumor response with minimal adverse effect. We reported that metronomic chemotherapy might be an option for the metastatic ACC of the trachea refractory to radiation and chemotherapy.
延伸閱讀
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