Developing Drugs for Negative Symptoms of Schizophrenia

Translated Titles



劉智民(Chih-Min Liu)

Key Words

schizophrenia ; negative symptoms ; medication ; clinical trials ; 思覺失調症 ; 負性症狀 ; 藥物 ; 臨床試驗



Volume or Term/Year and Month of Publication

31卷2期(2017 / 06 / 01)

Page #

115 - 127+ii

Content Language


Chinese Abstract

Negative symptoms in schizophrenia represent a clinically important target for drug development due to their profound effect on an individual’s ability to function normally. The lack of effective medications for this domain of psychopathology is a major unmet medical need in schizophrenia. Earlier clinical trials for negative symptoms have been criticized mixing primary and secondary negative symptoms as treatment target and lack of standard protocols for clinical trial design. In the first part, The author is reviewing the methodological issues on defining and measuring negative symptoms and on developing the consensus for clinical trial design for negative symptoms. Deficit symptoms and persistent negative symptoms, instead of broadly defined negative symptoms, have been advocated as the treatment target of clinical trial. There were five commonly used interviewbased negative symptom scales with satisfactory psychometric profiles. The consensus has been achieved for the design of clinical trials for negative symptoms. In the second part, the treatment efficacy of different class of drugs on negative symptoms is reviewed. Some second-generation antipsychotics, antidepressants, psychostimulants, glutamate pathway molecules, serotonin receptor antagonists, and anti-inflammatory agents have modest effects on improving negative symptoms than placebo. Although some statistically significant effects on negative symptoms are evident, none has reached the threshold for clinically significant. Several new molecules with potentials in treating negative symptoms are still in development.

English Abstract


Topic Category 醫藥衛生 > 社會醫學
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Times Cited
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