Experience in Treatment of Patients with Gestational Trophoblastic Disease

Chi-Feng Su ； Long-Yau Lin ； Po-Hui Wang ； Gin-Den Chen ； William R. Bell

《Taiwanese Journal of Obstetrics & Gynecology》 44卷2期 (2005/06) Pp. 139-142

https://doi.org/10.29787/TJOG.200506.0005

並列摘要

Objective: To determine outcome in patients with hydatidiform mole and gestational trophoblastic tumor after successful treatment.
Materials and Methods: This was a retrospective review of outcome in 22 patients with gestational trophoblastic disease (GTD) who completed human chorionic gonadotropin (hCG) follow-up for 1 year or more after treatment between 1999 and 2003.
Results: The mean age of patients with GTD was 32.5 years. Sixteen patients (72.7%) with hydatidiform mole and six (27.3%) with gestational trophoblastic tumor were evaluated. One patient (4.5%) with metastatic choriocarcinoma experienced complete remission after debulking surgery followed by chemotherapy. Fifteen patients (68.2%) with persistent GTD were diagnosed by hCG follow-up. After at least 1 year, eight patients (36.4%) conceived and six (27.3%) delivered a healthy term baby. All patients experienced an excellent prognostic outcome following chemotherapy and there were no deaths.
Conclusion: GTD exhibited an excellent response to chemotherapy and subsequent successful pregnancy was achieved in some patients 1 year or more after completion of treatment. Patients without previous childbirth desired subsequent pregnancy. Patients must be followed-up carefully after treatment and during conception.

並列關鍵字

chemotherapy ； gestational trophoblastic disease ； metastatic choriocarcinoma ； subsequent pregnancy