Primary Vaginal Amelanotic Melanoma




Hsia-Kuei Huang;I-Feng Liu;Chung-Liang Ho;Cheng-Yang Chou;Ya-Min Cheng

Key Words

amelanotic melanoma ; HMB-45 ; immunohistochemistry ; Melan-A ; S-100


Taiwanese Journal of Obstetrics & Gynecology

Volume or Term/Year and Month of Publication

44卷2期(2005 / 06 / 01)

Page #

177 - 179

Content Language


English Abstract

Objective: Primary vaginal melanoma is a very rare tumor entity, with a poor prognosis. The diagnosis is evident when melanin pigment is present within the tumor. However, the diagnosis of an amelanotic melanoma is problematic and should be differentiated from other conditions such as sarcoma, adenocarcinoma or small cell carcinoma. We present a patient with abnormal vaginal bleeding, with a diagnosis of amelanotic melanoma of the vagina confirmed by immunohistopathologic examination. Case Report: A 78-year-old woman was brought to our hospital because of postmenopausal vaginal bleeding for several days. Physical examination revealed two erythematous nodules, about 1 cm in size, in the upper- third of the vagina. Biopsy of the vaginal tumor showed a high-grade sarcoma. She underwent a wide local excision of the lesion, and histology confirmed the diagnosis of amelanotic melanoma due to strong staining of Melan-A. Conclusion: The diagnosis of amelanotic melanoma of the vagina is sometimes difficult. Immunohistochemistry may be required to provide additional diagnostic information in problematic cases.

Topic Category 醫藥衛生 > 預防保健與衛生學
醫藥衛生 > 婦產科與老幼科
醫藥衛生 > 社會醫學