Title

Familial chylomicronemia syndrome related chronic pancreatitis:a single-center study

Translated Titles

Familial chylomicronemia syndrome related chronic pancreatitis:a single-center study

Authors

Gurhan Sisman

Key Words

chronic pancreatitis ; hyperlipidemia ; treatment

PublicationName

Hepatobiliary & Pancreatic Diseases International

Volume or Term/Year and Month of Publication

13卷2期(2014 / 12 / 08)

Page #

209 - 214

Content Language

簡體中文

English Abstract

BACKGROUND:?Hypertriglyceridemia?induces?acute?recurrent?pancreatitis,?but?its?role?in?the?etiology?of?chronic?pancreatitis?(CP)?is?controversial.?This?study?aimed?to?evaluate?the?clinical,?laboratory?and?radiological?ifndings?of?7?patients?with?CP?due?to?type?1?hyperlipidemia?compared?to?CP?patients?with?other?or?undeifned?etiological?factors. <br> METHODS:?We?retrospectively?analyzed?the?clinical,?laboratory?and?radiological?ifndings?of?7?CP?patients?with?type?1?hyper- lipidemia?compared?to?CP?patients?without?hypertriglyceridemia.?These?7?patients?had?multiple?episodes?of?acute?pancreatitis?and?had?features?of?CP?on?abdominal?CT,?endoscopic?retrograde?cholangiopancreatography?and/or?endoscopic?ultrasonography. <br> RESULTS:?All?CP?patients?were?classiifed?into?two?groups:?a?group?with?type?1?hyperlipidemia?(n=7)?and?a?group?with?other?etiologies?(n=58).?The?mean?triglyceride?level?was?2323±894?mg/dL?in?the?ifrst?group.?Age?at?the?diagnosis?of?CP?in?the?ifrst?group?was?signiifcantly?younger?than?that?in?the?second?group?(16.5±5.9?vs?48.3±13.5,?P<0.001).?The?number?of?episodes?of?acute?pancreatitis?in?the?ifrst?group?was?signiifcantly?higher?than?that?in?the?second?group?(15.0±6.8?vs?4.0±4.6,?P=0.011).?The?number?of?splenic?vein?thrombosis?in?the?ifrst?group?was?signiifcantly?higher?than?that?in?the?second?group?(4/7?vs?9/58,?P=0.025).?Logistic?regression?analysis?found?that?younger?age?was?an?independent?predictor?of?CP?due?to?hypertriglyceridemia?(r=0.418,?P=0.000). <br> CONCLUSIONS:?Type? 1? hyperlipidemia? appears? to? be? an?etiological?factor?even?for?a?minority?of?patients?with?CP.?It?manifests?at?a?younger?age,?and?the?course?of?the?disease?might?be?severe.

Topic Category 醫藥衛生 > 內科