Anti-Tumor Potential of Apigenin and Luteolin in Cervical Cancer

Pei-Yin Yang ； Jui-Chang Hsu ； Chueh-Ko Yang ； Yu-Li Chuang ； Horng-Der Tsai ； Yi-Hsuan Hsiao

《The Changhua Journal of Medicine》 17卷4期 (2019/12) Pp. 139-147

https://doi.org/10.6501/CJM.201912_17(4).0001

摘要

Cervical cancer is one of the most common malignant tumors in women worldwide. Carcinogenesis is a continuous process of progression, distinct molecular changes resulting in cells undergoing uncontrolled cellular division. Phytochemicals may prevent carcinogens from landing at targeted sites and support detoxification of reactive molecules. Selected phytochemicals may promote innate immune surveillance and progress the elimination of transformed cells. Recently, flavonoids have been found to be important biologically-active compounds and have been used to treat many chronic diseases, such as cancer and viral, inflammatory, cardiovascular and neurodegenerative diseases, due to their potential health benefits. Flavonoids may be found in a wide variety of fruits, vegetables, and beverages. Flavones are a subclass of flavonoids, and apigenin and luteolin are the major flavones found in foods. There has been increasing concern regarding the use of these drugs in the treatment of cervical cancer in terms of drug resistance and potential side effects identified in vitro and in vivo. Luteolin and apigenin could have significant effects on various developmental hallmarks of cancer, and evidence has suggested the potential of luteolin and apigenin as drugs against cervical cancer. However, for development as an anticancer drug for clinical usage, further preclinical and clinical studies are required for validation of the antitumor effects of luteolin and apigenin applicable to the treatment of cervical cancer.

關鍵字

antitumor effects ； apigenin ； cervical cancer ； luteolin