This paper aims to explore the physiopsychological shocks and adjustment process of a 54-year-old patient with terminal-staged prostate cancer leading to paraplegia by tumor compression. The caring period was from August 30, 2007 to September 26, 2007. We collected information by direct care, observation and interview. By using functional evaluation of the healthful Gordon 11, we found patient had pain, physical activity dysfunction, fear, hopelessness, body image disturbance, abdominal distension and other nursing problems. During the application of holistic nursing interventions, we use empathy on the nursing care to provide appropriate guidance for psychological adjustment for disease progression in order to alleviate pain and help case to accept body image change, face real life and meet the physiopsychological, spiritual and social dimensions of the needs.