The rate of progression of interproximal caries depends on the following factors including use of fluorides, dentition stage, and open/closed contact area. There are different diagnostic techniques to detect interproximal caries, such as visual examination, fiber-optic transillumination, laser fluorescence, and bitewing radiography. The correlation of radiographic examination and clinical tissue changes are affected by the depth of radiolucent area, tooth type, and dentition stage. Use of interdental flossing, intensive use of fluorides, and use of xylitol chewing gum are effective modalities to decrease incidence and rate of progression of interproximal caries.