- 期刊
Endothelins as a Potential Target for Anticancer Therapy
並列摘要
The endothelin (ET) system consists of three small peptides (ET-1, ET-2, ET-3) and two ET receptors (ET(subscript A) and ET(subscript B)). ETs play key physiologic roles in normal tissue, acting as modulators of vasomotor tone, tissue differentiation, cell proliferation, and hormone production. Besides their physiologic roles, endothelins are implicated in pathologic conditions, such as vascular diseases and cancer. ET system is differentially expressed in invasive cancer compared to precancerous lesions and their normal tissue counterparts. In tumors, ETs exhibit antiapoptotic and angiogenic activities which facilitate malignant growth. Increased ET-1 production and ET(subscript A) receptor density keeps tumor vessels in vasoconstrictive state, leading to decreased perfusion, hypoxia and resistance to radiotherapy and chemotherapy. In this article, the potential of ETs as a target for anticancer therapy and novel therapeutic strategies are discussed.
延伸閱讀
- 鄭秋敏（2008）。Targeting prodrug-activating vectors for selectivecancer therapy〔博士論文，高雄醫學大學〕。華藝線上圖書館。https://doi.org/10.6832/KMU.2008.00127
- Wu, H. C., Huang, C. T., & Chang, D. K. (2008). Anti-Angiogenic Therapeutic Drugs for Treatment of Human Cancer. Journal of Cancer Molecules, 4(2), 37-45. https://doi.org/10.29685/JCM.200806.0001
- Ngo, F. Q. H., & Elkind, M. M. (1993). Oncogenic Mechanisms of Radiation-Induced Cancer. 中華放射線醫學雜誌, 18(2), 103-109. https://www.airitilibrary.com/Article/Detail?DocID=10188940-199306-18-2-103-109-a
- Chen, W. C., Tsai, P. Y., Lu, C. C., & Lin, I. C. (2010). The Role of Antibiotics Use in Terminal Cancer Patients. 安寧療護雜誌, 15(1), 1-12. https://doi.org/10.6537/TJHPC.2010.15(1).1
- 謝瑞坤（2003）。Molecular Targeted Therapy for Solid Tumors。台灣醫學，7(2)，222-226。https://doi.org/10.6320/FJM.2003.7(2).10