Hepatoprotective Effect of Aqueous Acetone Extract of Sida alba L. (Malvaceae) Against Alcohol Induced Liver Damage in albinos Wistar Rats

K. Konaté ； A. Souza ； R. R. R. Aworet Samseny ； B. Batchelili ； B. Marlaine ； M. Lamidi ； N. Barro ； J. Millogo-Rasolodimby ； O. G. Nacoulma

《British Journal of Pharmacology and Toxicology》 2卷1期 (2011/02) Pp. 37-42

並列摘要

The present study was conducted to evaluate the hepatoprotective effects of aqueous acetone extract of Sida alba. (Malvaceae) an herbal plant used in Burkina Faso to treat traditionally hepatics affections in albinos Wistar rats. Animals were treated by gavage during 28 days with different doses of aqueous acetone extracts of Sida alba. (75, 100, 150 mg/kg) suspended in 35% ethanol. Control groups received alcohol 35% and water. In vivo administration of 35% ethanol for 28 days results an activity of liver marker enzymes (AST, ALT, ALP), glucose, triglycerides, total cholesterol, total bilirubin and direct bilirubin in serum as compared with rats which received water (control water). However, administrations of 35% ethanol along with aqueous acetone extract decreased the activities of liver markers enzyme in serum comparatively to the control water group (p＜0.05 or p＜0.01). We noticed that extract at a dose of 150 mg/kg was highly effective than 75 and 100 mg/kg body weight compared to the control water group (ALT and ALP; p＞0.05 and p＜0.05). This study revealed that Sida alba presents a hepatoprotective potential and this plant could be traditionally exploited in the treatment of affection hepatics.

並列關鍵字

Albinos Wistar rats ； biochemical parameters ； hepatoprotective potential ； Sida alba