Exaggerated placental site (EPS) lesions occur due to excessive infiltration of the implantation site by intermediate trophoblasts. These lesions may occur after a normal pregnancy, molar pregnancy, ectopic pregnancy, or abortion (whether induced or spontaneous). While EPS lesions share some features with placental site trophoblastic tumors (PSTTs), they are considered benign and trophoblastic in nature and typically do not require special treatment. In this case report, we present and discuss a rare case of an EPS lesion that arose from an antecedent complete hydatidiform mole in a 53-year-old perimenopausal woman. In addition, we review the related literature regarding EPS lesions.
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