Using adenosine moiety as basic structure, we aimed at constructing a library of molecular probes for various protein kinases, including Lymphocyte protein tyrosine kinase,focal adhesion kinase, and mitogen-activated protein kinase. The construction of these probes involved the coupling of adenosine with various electrophilic groups that are linked by variable lengths of linkers. By combining the virtue of computational docking and organic syntheses, we have successfully established a library of molecular probes for the computational studies and bio-assay screening aiming at finding the highly specific probes.
為了持續優化網站功能與使用者體驗,本網站將Cookies分析技術用於網站營運、分析和個人化服務之目的。
若您繼續瀏覽本網站,即表示您同意本網站使用Cookies。