以電芬頓法去除水中酮洛芬之研究

Removal of Ketoprofen from Water by the Electro-Fenton Treatment Process

李珩(Hern Lee)

指導教授 ： 駱尚廉

國立臺灣大學/工學院/環境工程學研究所/碩士(2015年)

https://doi.org/10.6342/NTU.2015.02849

摘要

酮洛芬(Ketoprofen) ，全名2-(3-benzoylphenyl)propanoic acid，2-(3苯甲醯基苯基)丙酸，是非類固醇消炎止痛藥(Non-Steroidal Anti-Inflammatory Drugs，NSAIDs)的其中一種，為被廣泛使用的消炎止痛藥之一，常作為坐骨神經痛或是關節炎等徵狀的處方藥，此類藥物的使用量正逐年增加，而非類固醇類消炎止痛藥在水體中，會透過生物累積的作用影響整個生態系統。
酮洛芬在汙水處理廠中無法被有效去除，必須增加高級氧化法(AOP)單元來去除之，常見的高級氧化法有臭氧、光催化、Fenton、Fenton-like或是複合多種處理等方式，利用反應產生自由基的強氧化能力來降解水中之酮洛芬。
本研究以電芬頓法(Electro-Fenton，EF)處理水中酮洛芬，利用高效液相層析儀(High-Performance Liquid Chromatography，HPLC)來檢測處理效率與各項參數，再將得到的數據整理並利用反應曲面法(Response Surface Methodology，RSM)來找出最佳的處理參數範圍。在電解法與芬頓法的背景實驗中，分別測試控制電流大小、pH值、過氧化氫以及鐵離子加藥量等變數，得知處理效率隨pH的降低而提升，隨著過氧化氫及鐵離子的加藥量上升而提升。在電芬頓法的實驗中，分別控制電流大小、pH值、過氧化氫以及鐵離子加藥量來探討對酮洛芬的處理效率，電流大小在加藥量充足時，對處理效率影響不大，pH值與過氧化氫加藥量的影響趨勢與芬頓法相似，而鐵離子加藥量在電芬頓法中因提供電場可促使其循環利用，相較於芬頓法，需求量較低。
在反應曲面法中央合成設計實驗中，將變數設定為pH(2~4)、過氧化氫加藥量(0.01~0.1 mM)、鐵離子加藥量(0.01~0.1 mM)，透過批次實驗，可找出最佳的處理效率發生在pH=2，過氧化氫與鐵離子加藥量0.1 mM，對酮洛芬的處理效率可達96%，證明電芬頓法是一種可行的處理酮洛芬的方法。

關鍵字

酮洛芬 ； 非類固醇消炎止痛藥 ； 電芬頓法 ； 液相層析儀 ； 反應曲面法

並列摘要

Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) are a class of drugs widely provides analgesic (Pain-killing) and antipyretic (Fever-reducing) effects. Ketoprofen (KET), [2-(3-benzoylphenyl)propanoic acid] is one of the propionic acid class of NSAIDs. KET is mainly used for treatment of musculoskeletal pain. KET can also be used for treatment of some nerve pain such as sciatica. In recent years, the amount of use for NSAIDs is increasing rapidly in developed countries. Therefore, the presence of these pharmaceuticals in water system becomes a growing problem in these decades.
Since the sewage treatment plant can’t eliminate the NSAIDs efficiently, the treatment which usually applied for the removal of NSAIDs is Advanced Oxidation Process (AOP). Advanced oxidation process such as Ozonation, Fenton/Fenton-like, Photocatalysis or Electrolysis all using the hydroxyl radical (•OH) to mineralized the target compounds in water.
The goal of this research is to find out the removal efficiency of KET in water by using Electro-Fenton process (EF). Using HPLC to quantified the residual KET in water solution after the EF process. Applying response surface methodology (RSM) to approach the optimal operation conditions.
In the background test of Electrolysis and Fenton reaction, four different operating parameters (current level, pH, hydrogen peroxide [H2O2] and iron [Fe2+] dosage) were tested. The removal efficiency increased with the decreasing pH and increasing H2O2 and Fe2+ dosage. In the EF batch experiments, four operating parameters, current level, pH, H2O2 and Fe2+ dosage were tested. The removal efficiency increased with pH decreasing and increasing H2O2 dosage, which followed the same patterns as Fenton experiment. However, the reduction reaction in cathode contributed to less Fe2+ required for Electro-Fenton process. The Fe3+ was converted to Fe2+ in this reduction process. The current level didn’t affect the removal efficiency significantly when applying enough H2O2 and Fe2+.
By choosing pH range from 2 to 4, H2O2 and Fe2+ dosage from 0.01 to 0.1 mM as the varieties in the response surface methodology, tested a sequence of the design experiments. The removal efficiency can reach 96% at pH=2, H2O2=0.1 mM and Fe2+=0.1 mM. In conclusion, the EF process is a decent method for the elimination of KET.

並列關鍵字

Ketoprofen ； Nonsteroidal anti-inflammatory drugs ； Electro-Fenton process ； High-performance liquid chromatography ； Response surface methodology

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