利用紫外光聚合溫度敏感性聚氮-異丙基丙烯醯胺及其共聚合體

Studies on Thermosensitive Poly(N-isopropylacrylamide) and its Copolymers Synthesized by Photo-Polymerization

李宛蓉(Wan-Jung Li)

指導教授 ： 董崇民

淡江大學/工學院/化學工程與材料工程學系碩士班/碩士(2010年)

https://doi.org/10.6846/TKU.2010.00801

摘要

本研究是利用紫外光聚合法合成溫度敏感型聚(氮-異丙基丙烯醯胺)(PNIPAAm)自聚物及聚(2-丙烯醯胺-甲基-1-丙烷磺酸)[P(NIPAAm-co-AMPS)]共聚物，並期望AMPS的添加可使共聚合體擁有磺酸根，同時共聚合體也會有較高的膨潤性、體積相轉移溫度及玻璃轉移溫度。本實驗所使用的交聯劑為N,N’-亞甲基雙丙烯醯胺(MBA)，光起始劑為2-羥基-2-甲基-1-苯基-1-丙酮(Darocure 1173)。因為Darocure 1173為疏水性光起始劑，因此使用水/乙醇混合溶劑系統，本實驗的第一部份為在改變交聯劑比例及水/乙醇混合溶劑體積比下合成PNIPAAm自聚物，結果顯示隨著水/乙醇體積比提升或交聯劑比例增加時，PNIPAAm的轉化率也會提升，但膨潤比(Swelling ratio，SR)與體積相轉移溫度(Volume phase transition temperture，VPTT)卻隨之下降。在第二部份中，則是固定水/乙醇體積比為1/1，藉由改變交聯劑及AMPS單體的添加比例來合成P(NIPAAm-co-AMPS)共聚物探討其性質，結果顯示當AMPS添加比例增加時，共聚物的膨潤比、體積相轉移溫度及保水力皆有提升，這是因為AMPS上的磺酸根具有極強的親水性。最後，將PNIPAAm及P(NIPAAm-co-AMPS)共聚合體進行藥物釋放動力研究。

關鍵字

溫度敏感型 ； 紫外光聚合 ； 聚(氮-異丙基丙烯醯胺) ； 2-丙烯醯胺-甲基-1-丙烷磺酸 ； 膨潤動力

並列摘要

In this study, we synthesized thermosensitive poly(N-isopropylacrylamide，PNIPAAm) homoolymer and PNIPAAm/poly(2-Acrylamido-2-methyl-1-propanesulfonic acid，PAMPS) copolymer by photo-polymerization. We hope the sulfonic acid group of AMPS to increase the swelling ratio, volume phase transition temperature and glass transition temperature of copolymer. We use the N,N’-methylenebisacrylamide(MBA) as crosslinker and 2-Hydroxy-2-methyl-1-phenyl-propanone(Darocure 1173) as photo-initiator. Because the Darocure 1173 is hydrophobic initiator, we use water/ethanol as mixture solvent. In the first part of this study, we synthesize the PNIPAAm by changing the ratio of crosslinker and the volume ratio of water and ethanol. When we increase the ratio of crosslinker and the volume ratio of water and ethanol, the conversion of PNIPAAm would increase, but the swelling ratio (SR) and Volume phase transition temperature (VPTT) would decrease. The second part of this study, we regulate the ratio of water and ethanol for 1/1, and synthesize the P(NIPAAm-co-AMPS) copolymer by changing the ratio of crosslinker and the ratio of AMPS monomer. When increasing the ratio of AMPS monomer, the sweling ratio, VPTT and water retension capability of the copolymer would increse. Then reason is the strong hydrophilicy of the sofonic acid group of the AMPS. Finally, we study the drug relaese kinetic with PNIPAAm and P(NIPAAm-co-AMPS) copolymer.

並列關鍵字

Thermosensitive ； Photo-polymerization ； PNIPAAm ； AMPS ； Swelling kinetic

參考文獻

6. 周書仲, 幾丁聚醣選擇性接枝聚氮-異丙基丙烯醯胺的合成及其酸鹼/溫度敏感性質研究. 2007年碩士論文, 淡江大學. 台灣.

1. Wichterle, O.,D.Lim, Hydrophilic Gels for Biological Use Nature, 1960. 185(4706): p. 117-118.

2. Peppas, N.A., P. Bures, W. Leobandung,H. Ichikawa, Hydrogels in pharmaceutical formulations. European Journal of Pharmaceutics and Biopharmaceutics, 2000. 50: p. 27-46.

3. Ruel-Garie’py, E.,J.-C. Leroux, In situ-forming hydrogels—review of temperature-sensitive systems. European Journal of Pharmaceutics and Biopharmaceutics, 2004. 58: p. 409-426.

4. Kim, J.H., S.B. Lee, S.J. Kim,Y.M. Lee, Rapid Temperature/pH Response of Porous Alginate-g-Poly(N-isopropylacrylamide) Hydrogels. Polymer, 2002. 43: p. 7549-7558.