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  • 學位論文

亞麻仁油酸改質聚胺酯的合成鑑定與血液相容性的探討

Synthesis, Characterization and Hemocompatibility Studies of the Linoleic-acid-modified Polyurethanes

指導教授 : 王賢達
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摘要


本研究中,是以對甲苯磺酸(p-TSA)當催化劑,將聚氧四亞甲基二醇(PTMO,M.W.:1000g/mole)與亞麻仁油酸(LA)進行酯化反應,得亞麻仁油酸改質之聚氧四亞甲基二醇(PTMOLA),接著將PTMOLA與4,4’-二苯甲烷二異氰酸鹽(MDI)進行預聚合反應;再以1,4-丁二醇(BD)行鏈延長反應,得到亞麻仁油酸改質之聚胺酯(PULA),隨後改變PTMOLA 、MDI 及之BD比例,得不同硬鏈節組成之亞麻仁油酸改質聚胺酯。另外以不同比例之PTMO 及MDI 先行預聚合反應,再以BD行鏈延長反應,得不同成分聚胺酯(PU)。 以NMR鑑定PULA及PU之結構,IR及微分掃描熱卡計(DSC)鑑定上述材料之氫鍵鍵結情形及微相分離程度。 DSC結果顯示:當MDI 及BD添加比例提高時,Tg慢慢上升。其解釋為:硬鏈溶於軟鏈之比例提升,微相分離程度越差。另外當MDI 及BD添加比例提升時Tm則明顯提升,此現象則為硬節之有效鏈長變長而造成。親水性則隨著MDI 及BD添加比例提升而下降。 TGA結果顯示:各材料之Td差異不大。但以20﹪質量損失來看,微相分離程度越好的材料其熱烈解穩定度較好。 拉伸測試結果來看,材料之抗拉強度會隨硬鏈節的含量增加而上升,斷裂延伸則會隨硬鏈節的含量增加而下降。 蛋白質吸附測試結果顯示:改質聚胺酯硬鏈節提升至55%以上時,有較低的HPF/HAS 比值。SEM觀察血小板吸附於各個材料上之型態,發現當改質聚胺酯硬鏈節提升至55%以上時其血小板變異度較小,有較佳的抗凝血性質。

並列摘要


Linoleic-acid-modified polyurethanes (PULA) have been synthesized using different ratios of 4,4’-diphenylmethane diisocyanate (MDI), 1,4-butanediol (BD) and esterified poly(tetramethylene oxide) (PTMOLA) which para-toluene sulfonic acid was chosen as catalyst. Polyurethanes (PU) were prepared with similar ratios of MDI, BD and poly(tetramethylene oxide) (PTMO). In comparison, microphase separation, thermal property, tensile strength and hemocompatibility were studied between PTMOLA and PU. PU and PULA have shown similar properties in microphase separation determined by infrared spectroscopy, thermal behavior (glass transition temperature, melting point, enthalpy, and decomposition temperature), and contact angles, for samples prepared with the same compositions. PU samples exhibit better tensile strength, human serum albumin adsorption and prevention of blood clotting than those of PULA samples prepared with the same formulas. However, PULA’s with over 55% hard segment composition show higher human serum albumin adsorption and avoidance of platelet aggregation in comparison with those of corresponding PU samples.

參考文獻


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