運用量化指標來表達疾病與疾病之關係

Exploit Quantitative Index to Express the Relationship Of Disease and Disease

吳思慧(Sz-Hui Wu)

指導教授 ： 李友專

臺北醫學大學/醫學科技學院/醫學資訊研究所/碩士(2012年)

摘要

癌症一直是國人高居不下的死亡原因，也是政府所關切的議題。有學者探討癌症與其他疾病之關聯，如糖尿病與癌症以及蕁麻疹與癌症之關係，更有學者提出使用統計的方法來描述疾病與疾病之間的關聯性，本論文的初步研究便是要探討皮膚科疾病與癌症之間的關係，提出使用量化指標來描述皮膚疾病與癌症的相關性，即兩疾病間之共病組合，再搭配所設定的疾病篩選，篩選出的疾病共病組合，最後經由文獻查證，分為已知共病組、未知共病組，以驗證量化指標的實用性。本論文所採用的資料為2000-2002年之全民健康保險資料庫。研究發現，病毒疣與乳癌、紅斑鱗狀皮膚病與大腸癌符合本研究的疾病篩選，基於文獻查證，兩疾病共病組合具有可能的潛在性的疾病相關性。

關鍵字

量化指標 ； 共病組合 ； 疾病與疾病關係

並列摘要

Cancer cause of death in Taiwan citizens has been always high, and it is also the main issue of concern for the Taiwan government. Some scholars investigate the association of cancer and other diseases, such as the relationship of diabetes and cancer, as well as that of urticaria and cancer. And some researchers use statistical methods to describe the correlation between disease and other disease. The preliminary study of this paper is to explore the relationship between skin disease and cancer, and propose to use the quantitative index to describe skin diseases and cancer, i.e. related co-morbidity combinations. And then with a set of predefined threshold, we filter out co-morbidity combinations of diseases and finally obtain the possible co-morbidity combinations. Literature reviewing is adopted to verify the usefulness of quantitative index. Through literature reviewing, the comorbidity combinations could be divided into known disease combinations and unknown disease combinations. The dataset used in this paper is National Health Insurance Database from 2000 to 2002. According to this study finding, the possible potential comorbidity combinations are virus warts with breast cancer, as well as erythema squamous skin diseases with colorectal cancer.

並列關鍵字

co-morbidity combinations ； quantitative index, ； relationship of disease and disease

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