Title

天然物-台灣大戟抗光老化活性成分之研究

Translated Titles

Anti-photoaging Activity of Natural Products Research in Euphorbia formosana

Authors

余佳純

Key Words

抗光老化 ; 基質金屬蛋白酶細胞外基質 ; anti-photoageing ; matrix metalloproteinases (MMPs) ; extracellular matrix (ECM)

PublicationName

臺北醫學大學生藥學研究所學位論文

Volume or Term/Year and Month of Publication

2009年

Academic Degree Category

碩士

Advisor

李慶國

Content Language

繁體中文

Chinese Abstract

隨著地球臭氧層的破壞,使得皮膚曝曬在紫外線下的機會增加,導致皮膚提早老化和皮膚癌的發生;在光老化的過程中,基質金屬蛋白酶(Matrix metalloproteinase,簡稱MMPs)扮演了一個重要的角色,本研究藉由抑制 MMP-2 和 MMP-9 的活性,使皮膚細胞外基質(Extracellular matrix,簡稱ECM)不受到 MMP-2 和 MMP-9 的分解而造成皮膚老化。因此,先前本實驗室已將台灣常用的 49 種藥用植物利用 MMP-2 和 MMP-9進行抗光老化的酵素活性篩選,其中以台灣大戟(Euphorbia formosana Hayata)植物抑制 MMP-2 和 MMP-9 的效果為最佳。 將台灣大戟植物利用人類纖維肉瘤細胞(Human fibrosarcoma cell) HT-1080 細胞中的 MMP-2 與 MMP-9 的活性追蹤方式進行成分的分離及純化,並利用化合物之核磁共振與物理數據等光譜數據,共計純化出 38 個化合物,包括:九個 aliphatic 類化合物、九個 triterpenoid 類化合物、六個 diterpenoid 類化合物、三個 steroid 類化合物、二個 phaeophorbide 類化合物、一個 coumarin 類化合物、一個 aromatic 類化合物、一個 norisoprenoid 類化合物、一個 purine alkaloid 類化合物、一個 polyketide 類化合物、一個 polyprenol 類化合物、一個 lignin 類化合物、二個 others 類化合物。上述38個化合物,其中seco-Helioscopinolde (EF12)、3β,7β-Dihydroxy-ent-abieta-8,13-diene-16,12-olide (EF13) 為新化合物。 將純化合物對於 MMP-2 和 MMP-9 作活性篩選,實驗結果發現這些化合物對於 MMP-2 與 MMP-9 的抑制效果不佳,與先前的研究結果活性表現不一致,推測是先前的研究中,利用萃取液直接對 MMP-2 和 MMP-9 作酵素反應,而在本研究中則是利用化合物對 HT-1080 細胞作試藥處理,經由細胞內的訊息調控後,取其細胞外液作 Gelatin Zymography 實驗,分析化合物對 MMP-2 與 MMP-9 的活性表現,因此,針對於 MMP 的抑制作用可能藉由不同的基因表現方式,而造成兩者之間對 MMP-2 與 MMP-9 活性表現的差異,期待未來可藉由不同的化合物調控 MMP 的蛋白表現或酵素活性,期待能開發作為新一代天然的抗光老化產品。

English Abstract

With increasing UV exposure of skin leads to acute and chronic detrimental cutaneous effects, which may result in development of skin malignancies and photoaging. The Matrix Metalloproteinases (MMPs) play an important role in the photoaging process, which degrade macromolecules of the extracellular matrix (ECM) to increase the happening of wrinkling, sagging and laxity. We examine the MMP-2 and MMP-9 activity for the factor in photoaging process that can degrade collagen and components of the elastic network. In the previous studies, our groups had screened 49 species of pharmaceutical plants in Taiwan by anti-photoaging screening model using MMP-2 and MMP-9 enzyme activity. The results demonstrated that Euphorbia formosana had better inhibition of MMPs activity in HT-1080 cells. In Euphorbia formosana, 38 compounds had been isolated and purified by using HPLC and spectroscopy for structure elucidation. There is included nine aliphatic compounds, nine tritepenoids, six diterpenoids, three steroids, two phaeophorbides, one coumarin, one aromatic structure, one norisoprnoid, one purine alkaloid, one polyketide, one poylprenol, one lignan, and the others. Among them, seco-Helioscopinolde (EF12), 3β,7β-Dihydroxy-ent-abieta-8,13-diene-16,12-olide (EF13) are discovered and identified in first time. All purified compounds were evaluated the MMP-2 and MMP-9 acitivity in HT-1080 cells, and the results indicated that neither one showed the inhibition of MMP-2 and MMP-9 activity, which were not coincide with the previous study. We were speculating that the difference in crude extracts with MMP-2 and MMP-9 enzyme reaction and compounds were treated to human fibrosarcoma cell (HT-1080) by cell signaling regulation. We supposed that the acitivity of MMP-2 and MMP-9 may be modulated by several genes expression, which resulting in the difference between enzyme reaction and cell signaling. The development for MMP inhibition will require the different compounds in modulating MMP protein expression or enzyme activity, which will be an anti-photoageing products from natural source in new generation.

Topic Category 醫藥衛生 > 藥理醫學
藥學院 > 生藥學研究所
Reference
  1. 5.Goihman-Yahr, M., Skin aging and photoaging: an outlook. Clinical Dermatology 1996, 14, (2), 153-160.
    連結:
  2. 6.Zhang, G.; Luo, X.; Sumithran, E.; Pua, V.; Barnetson, R.; Halliday, G.; Khachigian, L., Squamous cell carcinoma growth in mice and in culture is regulated by c-Jun and its control of matrix metalloproteinase-2 and -9 expression. Oncogene 2006, 25, 7260-7266.
    連結:
  3. 8.Urbach, F., The historical aspects of sunscreens. Journal of Photochemistry and Photobiology B: Biology 2001, 64, 99-104.
    連結:
  4. 9.Lowe, N. J., An Overview of Ultraviolet Radiation, Sunscreens, and Photo-Induced Dermatoses. Dermatologic Clinics 2006, 24, (1), 9-17.
    連結:
  5. 10.Rosen, C. F., Topical and systemic photoprotection. Dermatologic Therapy 2003, 15, (1), 8-15.
    連結:
  6. 11.Scharffetter-Kochanek, K.; Brenneisen, P.; Wenk, J.; Herrmann, G.; Weijan Ma, L. K.; Meewes, C.; Wlaschek, M., Photoaging of the skin from phenotype to mechanisms. Experimental Gerontology 2000, 35, (3), 307-316.
    連結:
  7. 12.Gilchrest, B., Skin aging and photoaging: an overview. Journal of the American Academy of Dermatology 1989, 21, (3 Pt 2), 610-613.
    連結:
  8. 13.Rittié, L.; Fisher, G. J., UV-light-induced signal cascades and skin aging. Ageing Research Reviews 2002, 1, (4), 705-720.
    連結:
  9. 14.Griffiths, C. E. M., The role of retinoids in the prevention and repair of aged and photoaged skin. Clinical and Experimental Dermatology 2001, 26, (7), 613-618.
    連結:
  10. 15.Fisher, G. J.; Kang, S.; Varani, J.; Bata-Csorgo, Z.; Wan, Y.; Datta, S.; Voorhees, J. J., Mechanisms of photoaging and chronological skin aging. Archives of Dermatology 2002, 138, (11), 1462-1470.
    連結:
  11. 16.Trautinger, F., Mechanisms of photodamage of the skin and its functional consequences for skin ageing. Clinical and Experimental Dermatology 2001, 26, (7), 573-577.
    連結:
  12. 17.Emerit, I., Free radicals and aging of the skin. EXS 1992, 62, 328-341.
    連結:
  13. 18.Anthony V. Benedetto, D., The environment and skin aging. Clinics in Dermatology 1998, 16, (1), 129-139.
    連結:
  14. 20.Pugliese, P., The skin, free radicals, and oxidative stress. Dermatology Nursing 1995, 7, (6), 361-369.
    連結:
  15. 23.Philips, N.; Smith, J.; Keller, T.; Gonzalez, S., Predominant effects of Polypodium leucotomos on membrane integrity, lipid peroxidation, and expression of elastin and matrixmetalloproteinase-1 in ultraviolet radiation exposed fibroblasts, and keratinocytes. Journal of Dermatological Science 2003, 32, (1), 1-9.
    連結:
  16. 24.Gilchrest, B.; Yaar, M., Aging and photoaging of the skin: observations at the cellular and molecular level. The British Journal of Dermatology 1992, 127, (Suppl 41), 25-35.
    連結:
  17. 26.Bernstein, E. F.; Uitto, J., The effect of photodamage on dermal extracellular matrix. Clinics in Dermatology 1996, 14, (2), 143-151.
    連結:
  18. 28.Yong, V. W.; Power, C.; Forsyth, P.; Edwards, D. R., Metalloproteinases in biology and pathology of the nervous system. Nature Reviews Neuroscience 2001, 2, 502-511.
    連結:
  19. 29.Vu, T. H.; Werb, Z., Matrix metalloproteinases: effectors of development and normal physiology. Genes and Development 2000, 14, 2123-2133.
    連結:
  20. 31.Page-McCaw, A.; Ewald, A. J.; Werb, Z., Matrix metalloproteinases and the regulation of tissue remodelling. Nature Reviews Molecular Cell Biology 2007, 8, 221-233.
    連結:
  21. 32.Stetler-Stevenson, W. G., Matrix metalloproteinases in angiogenesis: a moving target for therapeutic intervention. The Journal of Clinical Investigation 1999, 103, (9), 1237-1241.
    連結:
  22. 34.Parks, W. C.; Mecham, R. P., Matrix metalloproteinases (Biology of Extracellular Matrix). Academic Press 1998, 1-362.
    連結:
  23. 36.Dollery, C. M.; McEwan, J. R.; Henney, A. M., Matrix Metalloproteinases and Cardiovascular Disease Circulation Research 1995, 77, 863-868.
    連結:
  24. 37.Sivak, J. M.; Fini, M. E., MMPs in the eye: emerging roles for matrix metalloproteinases in ocular physiology. Progress in Retinal and Eye Research 2002, 21, (1), 1-14.
    連結:
  25. 39.Otani, Y.; Sakurai, Y.; Kameyama, K.; Igarashi, N.; Yokoyama, T.; Kubota, T.; Kumai, K.; Kitajima, M., Matrix Metalloproteinase Gene Expression in Chronic Gastric Ulcer: A Potential Role of Eosinophils in Perforation. Journal of Clinical Gastroenterology 1997, 25, S101-S104.
    連結:
  26. 40.O'Connor, C. M.; FitzGerald, M. X., Matrix metalloproteases and lung disease. British Medical Journal 1994, 49, 602-609.
    連結:
  27. 41.Arthur, M. J. P., Fibrogenesis II. Metalloproteinases and their inhibitors in liver fibrosis. American Journal of Physiology- Gastrointestinal and Liver Physiology 2000, 279, 245-249.
    連結:
  28. 43.Werb, C. C. a. Z., The many faces of metalloproteases: cell growth, invasion, angiogenesis and metastasis. Trends in Cell Biology 2001, 11, (11), S37-S43.
    連結:
  29. 44.Wan, Y. S.; Wang, Z. Q.; Voorhees, J.; Fisher, G., EGF receptor crosstalks with cytokine receptors leading to the activation of c-Jun kinase in response to UV irradiation in human keratinocytes. Cellular Signalling 2001, 13, (2), 139-144.
    連結:
  30. 45.Fisher, G. J.; Talwar, H. S.; Lin, J.; Voorhees, J. J., Molecular mechanisms of photoaging in human skin in vivo and their prevention by all-trans retinoic acid. Photochemistry and Photobiology 1999, 69, (2), 154-157.
    連結:
  31. 46.Greul, A. K.; Grundmann, J. U.; Heinrich, F.; Pfitzner, I.; Bernhardt, J.; Ambach, A.; Biesalski, H. K.; Gollnick, H., Photoprotection of UV-irradiated human skin: an antioxidative combination of vitamins E and C, carotenoids, selenium and proanthocyanidins. Skin Pharmacology and Applied Skin Physiology 2002, 15, 307-315.
    連結:
  32. 47.Fisher, G. J.; Datta, S. C.; Talwar, H. S.; Wang, Z. Q.; Varani, J.; Kang, S.; Voorhees, J. J., Molecular basis of sun-induced premature skin ageing and retinoid antagonism. Nature 1996, 379, 335-339.
    連結:
  33. 48.Fisher, G. J.; Wang, Z.; Datta, S. C.; Varani, J.; Kang, S.; Voorhees, J. J., Pathophysiology of premature skin aging induced by ultraviolet light. The New England Journal of Medicine 1997, 337, (20), 1419-1428.
    連結:
  34. 49.Griffith, L. G.; Swartz, M. A., Capturing complex 3D tissue physiology in vitro. Nature Reviews Molecular Cell Biology 2006, 7, 211-224.
    連結:
  35. 50.Kähäri, V. M.; Kere, U. S., Matrix metalloproteinases in skin. Experimental Dermatology 1997, 6, (5), 199-213.
    連結:
  36. 51.Pilcher, B. K.; Wang, M.; Qin, X. J.; Parks, W. C.; Senior, R. M.; Welgus, H. G., Role of matrix metalloproteinases and their inhibition in cutaneous wound healing and allergic contact hypersensitivity. Annals of the New York Academy of Sciences 1999, 878, 12-24.
    連結:
  37. 52.Yaar, M.; Gilchrest, B. A., Photoageing: mechanism, prevention and therapy. British Journal of Dermatology 2007, 157, (5), 874-887.
    連結:
  38. 53.Sternlicht, M. D.; ZenaWerb, How matrix metalloproteinases regulate cell behavior. Annual review of cell and developmental biology 2001, 17, 463-516.
    連結:
  39. 54.Visse, R.; Nagase, H., Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases: Structure, Function, and Biochemistry. Circulation Research 2003, 92, 827-839.
    連結:
  40. 55.Overall, C. M.; López-Otín, C., Strategies for MMP inhibition in cancer: innovations for the post-trial era. Nature Reviews Cancer 2002, 2, 657-672.
    連結:
  41. 56.Cury, P. R.; Araújo, V. C. d.; Canavez, F.; Furuse, C.; Leite, K. R. M.; Araújo, N. S. d., The effect of epidermal growth factor on matrix metalloproteinases and tissue inhibitors of metalloproteinase gene expression in cultured human gingival fibroblasts. Archives of Oral Biology 2007, 52, (6), 585-590.
    連結:
  42. 57.Gross, J.; Lapiere, C. M., Collagenolytic activity in amphibian tissues: a tissue culture assay. Proceedings of the National Academy of Sciences 1962, 48, 1014-1022.
    連結:
  43. 58.Greenlee, K. J.; Werb, Z.; Kheradmand, F., Matrix Metalloproteinases in Lung: Multiple, Multifarious, and Multifaceted. Physiological Reviews 2007, 87, 69-98.
    連結:
  44. 60.Lafleur, M. A.; Handsley, M. M.; Edwards, D. R., Metalloproteinases and their inhibitors in angiogenesis. Expert Reviews in Molecular Medicine 2003, 5, (23), 1-39.
    連結:
  45. 61.Nagase, H.; Jr., J. F. W., Matrix metalloproteinases. Journal of Biological Chemistry 1999, 274, (31), 21491-21494.
    連結:
  46. 62.Stolow, M. A.; Bauzon, D. D.; Li, J.; Sedgwick, T.; Liang, V. C.-T.; Sang, Q. A.; Shi, Y.-B., Identification and characterization of a novel collagenase in Xenopus laevis: possible roles during frog development. Molecular Biology of the Cell 1996, 7, (10), 1471-1483.
    連結:
  47. 63.Hotary, K. B.; Allen, E. D.; Brooks, P. C.; Datta, N. S.; Long, M. W.; Weiss, S. J., Membrane type I matrix metalloproteinase usurps tumor growth control imposed by the three-dimensional extracellular matrix. Cell 2003, 114, (1), 33-45.
    連結:
  48. 65.Parks, W. C.; Wilson, C. L.; López-Boado, Y. S., Matrix metalloproteinases as modulators of inflammation and innate immunity. Nature Reviews Immunology 2004, 4, (8), 617-629.
    連結:
  49. 67.Docherty, A. J. P.; Lyons, A.; Smith, B. J.; Wright, E. M.; Stephens, P. E.; Harris, T. J. R.; Murphy, G.; Reynolds, J. J., Sequence of human tissue inhibitor of metalloproteinases and its identity to erythroidpotentiating activity. Nature 1985, 318, (7), 66-69.
    連結:
  50. 69.Herman, M. P.; Sukhova, G. K.; Kisiel, W.; Foster, D.; Kehry, M. R.; Libby, P.; Schönbeck, U., Tissue factor pathway inhibitor-2 is a novel inhibitor of matrix metalloproteinases with implications for atherosclerosis. Journal of Clinical Investigation 2001, 107, (9), 1117-1126.
    連結:
  51. 70.Mott, J. D.; Thomas, C. L.; Rosenbach, M. T.; Takahara, K.; Greenspan, D. S.; Banda, M. J., Post-translational proteolytic processing of procollagen C-terminal proteinase enhancer releases a metalloproteinase inhibitor. Journal of Biological Chemistry 2000, 275, (2), 1384-1390.
    連結:
  52. 71.Pillai, S.; Oresajo, C.; Hayward, J., Ultraviolet radiation and skin aging: roles of reactive oxygen species, inflammation and protease activation, and strategies for prevention of inflammation-induced matrix degradation-a review. International Journal of Cosmetic Science 2005, 27, (1), 17-34.
    連結:
  53. 72.Chirco, R.; Liu, X. W.; Jung, K. K.; Kim, H. R. C., Novel functions of TIMPs in cell signaling. Cancer and Metastasis Reviews 2006, 25, (1), 99-113.
    連結:
  54. 74.Sethi, C. S.; Bailey, T. A.; Luthert, P. J.; Chong, N. H. V., Matrix metalloproteinase biology applied to vitreoretinal disorders. British Journal of Ophthalmology 2000, 84, 654-666.
    連結:
  55. 75.Murphy, G.; Willenbrock, F., Tissue inhibitors of matrix metalloendopeptidases. Methods in enzymology 1995, 248, 496-510.
    連結:
  56. 77.Webster, G. L., Classification of the Euphorbiaceae. Annals of the Missouri Botanical Garden 1994, 81, (1), 3-32.
    連結:
  57. 83.Cos, P.; Ying, L.; Calomme, M.; Hu, J. P.; Cimanga, K.; Poel, B. V.; Pieters, L.; Vlietinck, A. J.; Berghe, D. V., Structure-Activity Relationship and Classification of Flavonoids as Inhibitors of Xanthine Oxidase and Superoxide Scavengers. Journal of Natural Products 1998, 61, (1), 71-76.
    連結:
  58. 84.Crespo, I.; García-Mediavilla, M. V.; Almar, M.; González, P.; Tuñón, M. J.; Sánchez-Campos, S.; González-Gallego, J., Differential effects of dietary flavonoids on reactive oxygen and nitrogen species generation and changes in antioxidant enzyme expression induced by proinflammatory cytokines in Chang Liver cells. Food and Chemical Toxicology 2008, 46, (5), 1555-1569.
    連結:
  59. 85.Kampkötter, A.; Nkwonkam, C. G.; Zurawski, R. F.; Timpel, C.; Chovolou, Y.; Wätjen, W.; Kahl, R., Effects of the flavonoids kaempferol and fisetin on thermotolerance, oxidative stress and FoxO transcription factor DAF-16 in the model organism Caenorhabditis elegans. Archives of Toxicology 2007, 81, (12), 849-858.
    連結:
  60. 86.Takasawa, R.; Takahashi, S.; Saeki, K.; Sunaga, S.; Yoshimori, A.; Tanuma, S. i., Structure-activity relationship of human GLO I inhibitory natural flavonoids and their growth inhibitory effects Bioorganic & Medicinal Chemistry 2007, 16, (7), 3969-3975.
    連結:
  61. 87.Lin, R. D.; Chin, Y. P.; Hou, W. C.; Lee, M. H., The Effects of Antibiotics Combined with Natural Polyphenols against Clinical Methicillin-Resistant Staphylococcus aureus (MRSA). Planta Medica 2008, 74, (8), 840-846.
    連結:
  62. 88.Liu, A. L.; Wang, H. D.; Lee, S. M.; Wang, Y. T.; Du, G. H., Structure-activity relationship of flavonoids as influenza virus neuraminidase inhibitors and their in vitro anti-viral activities. Bioorganic and Medicinal Chemistry 2008, 16, (15), 7141-7147.
    連結:
  63. 90.Leung, H. W. C.; Lin, C. J.; Hour, M. J.; Yang, W. H.; Wang, M. Y.; Lee, H. Z., Kaempferol induces apoptosis in human lung non-small carcinoma cells accompanied by an induction of antioxidant enzymes Food and Chemical Toxicology 2007, 45, (10), 2005-2013.
    連結:
  64. 91.Park, E. J.; Kim, Y.; Kim, J., Acylated Flavonol Glycosides from the Flower of Inula britannica. Journal of Natural Products 2000, 63, (1), 34-36.
    連結:
  65. 92.Hou, L.; Zhou, B.; Yang, L.; Liu, Z. L., Inhibition of free radical initiated peroxidation of human erythrocyte ghosts by flavonols and their glycosides. Organic and Biomolecular Chemistry 2004, 2, (9), 1419-1423.
    連結:
  66. 93.Ibrahim, L. F.; El-Senousy, W. M.; Hawas, U. W., NMR spectral analysis of flavonoids from Chrysanthemum coronarium Chemistry of Natural Compounds 2007, 43, (6), 659-662.
    連結:
  67. 95.Wang, A. X.; Zhang, Q.; Jia, Z. J., A new furobenzopyranone and other constituents from Anaphalis lactea. Pharmazie 2004, 59, (10), 807-811.
    連結:
  68. 96.Hsu, H. Y.; Tsang, S. F.; Lin, K. W.; Yang, S. C.; Lin, C. N., Cell death induced by flavonoid glycosides with and without copper. Food and Chemical Toxicology 2008, 46, (7), 2394-2401.
    連結:
  69. 97.Zhu, J. T. T.; Choi, R. C. Y.; Chu, G. K. Y.; Cheung, A. W. H.; Gao, Q. T.; Li, J.; Jiang, Z. Y.; Dong, T. T. X.; Tsim, K. W. K., Flavonoids Possess Neuroprotective Effects on Cultured Pheochromocytoma PC12 Cells: A Comparison of Different Flavonoids in Activating Estrogenic Effect and in Preventing β-Amyloid-Induced Cell Death. Journal of Agricultural and Food Chemistry 2007, 55, (6), 2438-2445.
    連結:
  70. 98.Wang, L.; Tu, Y. C.; Lian, T. W.; Hung, J. T.; Yen, J. H.; Wu, M. J., Distinctive Antioxidant and Antiinflammatory Effects of Flavonols. Journal of Agricultural and Food Chemistry 2006, 54, (26), 9798-9804.
    連結:
  71. 99.Belinha, I.; Amorim, M. A.; Rodrigues, P.; Freitas, V. d.; Moradas-Ferreira, P.; Mateus, N.; Costa, V., Quercetin Increases Oxidative Stress Resistance and Longevity in Saccharomyces cerevisiae. Journal of Agricultural and Food Chemistry 2007, 55, (6), 2446-2451.
    連結:
  72. 100.deGraft-Johnson, J.; Kolodziejczyk, K.; Krol, M.; Nowak, P.; Krol, B.; Nowak, D., Ferric-Reducing Ability Power of Selected Plant Polyphenols and Their Metabolites: Implications for Clinical Studies on the Antioxidant Effects of Fruits and Vegetable Consumption. Basic and Clinical Pharmacology and Toxicology 2007, 100, (5), 345-352.
    連結:
  73. 101.Mamani-Matsuda, M.; Kauss, T.; Al-Kharrat, A.; Rambert, J.; Fawaz, F.; Thiolat, D.; Moynet, D.; Coves, S.; Malvy, D.; Mossalayi, M. D., Therapeutic and preventive properties of quercetin in experimental arthritis correlate with decreased macrophage inflammatory mediators Biochemical Pharmacology 2006, 72, (10), 1304-1310.
    連結:
  74. 102.Indap, M.; Radhika, S.; Motiwale, L.; Rao2, K., Quercetin: Antitumor activity and pharmacological manipulations for increased therapeutic gains. Indian Journal of Pharmaceutical Sciences 2006, 68, (4), 465-469.
    連結:
  75. 106.Lin, R.; Liu, J.; Gan, W.; Ding, C., Protective Effect of Quercetin on the Homocysteine-Injured Human Umbilical Vein Vascular Endothelial Cell Line (ECV304). Basic and Clinical Pharmacology and Toxicology 2007, 101, (3), 197-202.
    連結:
  76. 107.Okamura, H.; Mimura, A.; Yakou, Y.; Niwano, M.; Takahara, Y., Antioxidant activity of tannins and flavonoids in Eucalyptus rostrata Phytochemistry 1993, 33, (3), 557-561.
    連結:
  77. 109.Cimanga, K.; Ying, L.; Bruyne, T. d.; Apers, S.; Cos, P.; Hermans, N.; Bakana, P.; Tona, L.; Kambu, K.; Kalenda, D. T.; Pieters, L.; Berghe, D. v.; Vlietinck, A. J., Radical scavenging and xanthine oxidase inhibitory activity of phenolic compounds from Bridelia ferruginea stem bark Journal of Pharmacy and Pharmacology 2001, 53, (5), 747-761.
    連結:
  78. 110.Wu, Q. L.; Wang, S. P.; Du, L. J.; Zhang, S. M.; Yang, J. S.; Xiao, P. G., Chromone glycosides and flavonoids from hypericum japonicum Phytochemistry 1998, 49, (5), 1417-1420.
    連結:
  79. 111.Park, K. Y.; Lee, S. H.; Min, B. K.; Lee, K. S.; Choi, J. S.; Chung, S. R.; Min, K. R.; Kim, Y. s., Inhibitory Effect of Luteolin 4'-O-Glucoside from Kummerowia striata and Other Flavonoids on Interleukin-5 Bioactivity. Planta Medica 1999, 65, (5), 457-459.
    連結:
  80. 113.Murakami, N.; Mostaqul, H. M.; Tamura, S.; Itagaki, S.; Horii, T.; Kobayashi, M., New anti-malarial flavonol glycoside from Hydrangeae dulcis folium Bioorganic and Medicinal Chemistry letters 2001, 11, (18), 2445-2447.
    連結:
  81. 114.Mastuda, H.; Morikawa, T.; Ueda, K.; Managi, H.; Yoshikawa, M., Structural requirements of flavonoids for inhibition of antigen-Induced degranulation, TNF-α and IL-4 production from RBL-2H3 cells Bioorganic and Medicinal Chemistry 2002, 10, (10), 3123-3128.
    連結:
  82. 115.He, X.; Liu, R. H., Cranberry Phytochemicals: Isolation, Structure Elucidation, and Their Antiproliferative and Antioxidant Activities. Journal of Agricultural and Food Chemistry 2006, 54, (19), 7069-7074.
    連結:
  83. 116. Snijman, P. W.; Swanevelder, S.; Joubert, E.; Green, I. R.; Gelderblom, W. C. A., The antimutagenic activity of the major flavonoids of rooibos (Aspalathus linearis): Some dose-response effects on mutagen activation-flavonoid interactions. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 2007, 631, (2), 111-123.
    連結:
  84. 117.Ito, M.; Shimura, H.; Watanabe, N.; Tamai, M.; Hanada, K., Hepatoprotective Compounds from Canarium album and Euphorbia nematocypha. Chemical & Pharmaceutical Bulletin 1990, 38, (8), 2201-2203.
    連結:
  85. 119.Butterweck, V.; Jürgenliemk, G.; Nahrstedt, A.; Winterhoff, H., Flavonoids from Hypericum perforatum Show Antidepressant Activity in the Forced Swimming Test. Planta Medica 2000, 66, (1), 3-6.
    連結:
  86. 120.Xiong, Q.; Fan, W.; Tezuka, Y.; Adnyana, I. K.; Stampoulis, P.; Hattori, M.; Namba, T.; Kadota, S., Hepatoprotective Effect of Apocynum venetum and its Active Constituents. Planta Medica 2000, 66, (2), 127-133.
    連結:
  87. 121.Hammer, K. D. P.; Hillwig, M. L.; Solco, A. K. S.; Dixon, P. M.; Delate, K.; Murphy, P. A.; Wurtele, E. S.; Birt, D. F., Inhibition of Prostaglandin E2 Production by Anti-inflammatory Hypericum perforatum Extracts and Constituents in RAW264.7 Mouse Macrophage Cells. Journal of Agricultural and Food Chemistry 2007, 55, (18), 7323-7331.
    連結:
  88. 124.Fukai, T.; Marumo, A.; Kaitou, K.; Kanda, T.; Terada, S.; Nomura, T., Antimicrobial activity of licorice flavonoids against methicillin-resistant Staphylococcus aureus Fitoterapia 2002, 73, (6), 536-539.
    連結:
  89. 125.Navarro, A.; Heras, B. D.; Villar, A., Anti-Inflammatory and Immunomodulating Properties of a Sterol Fraction from Sideritis foetens Clem. Biological and Pharmaceutical Bulletin 2001, 24, (5), 470-473.
    連結:
  90. 126.Jin, J. L.; Lee, S.; Lee, Y. Y.; Kim, J. M.; Heo, J. E.; Yun-Choi, H. S., Platelet Anti-Aggregating Triterpenoids from the Leaves of Acanthopanax senticosus and the Fruits of A. sessiliflorus. Planta Medica 2004, 70, (6), 564-566.
    連結:
  91. 127.Ali, M. S.; Banskota, A. H.; Tezuka, Y.; Saiki, I.; Kadota, S., Antiproliferative Activity of Diarylheptanoids from the Seeds of Alpinia blepharocalyx. Biological and Pharmaceutical Bulletin 2001, 24, (5), 525-528.
    連結:
  92. 128.Ali, Z.; Khan, S. I.; Khan, I. A., Phytochemical Study of Actaea rubra and Biological Screenings of Isolates. Planta Medica 2006, 72, (14), 1350-1352.
    連結:
  93. 129.Akihisa, T.; Yasukawa, K.; Oinuma, H.; Kasahara, Y.; Yamanouchi, S.; Takido, M.; Kumaki, K.; Tamura, T., Triterpene alcohols from the flowers of compositae and their anti-inflammatory effects. Phytochemistry 1996, 43, (6), 1255-1260.
    連結:
  94. 130.Saeed, M. A.; Sabir, A. W., Antibacterial activity of Caesalpinia bonducella seeds. Fitoterapia 2001, 72, (7), 807-809.
    連結:
  95. 131.Jain, S. C.; Singh, B.; Jain, R., Antimicrobial activity of triterpenoids from Heliotropium ellipticum Fitoterapia 2001, 72, (6), 666-668.
    連結:
  96. 132.Akihisa, T.; Franzblau, S. G.; Ukiya, M.; Okuda, H.; Zhang, F.; Yasukawa, K.; Suzuki, T.; Kimura, Y., Antitubercular Activity of Triterpenoids from Asteraceae Flowers. Biological & Pharmaceutical Bulletin 2005, 28, (1), 158-160.
    連結:
  97. 133.Bringmann, G.; Hamm, A.; Günther, C.; Michel, M.; Brun, R.; Mudogo, V., Ancistroealaines A and B, Two New Bioactive Naphthylisoquinolines, and Related Naphthoic Acids from Ancistrocladus ealaensis. Journal of Natural Products 2000, 63, (11), 1465-1470.
    連結:
  98. 134.Dong, M.; He, X.; Liu, R. H., Phytochemicals of Black Bean Seed Coats: Isolation, Structure Elucidation, and Their Antiproliferative and Antioxidative Activities. Journal of Agricultural and Food Chemistry 2007, 55, (15), 6044-6051.
    連結:
  99. 135.Zou, J. H.; Dai, J.; Chen, X.; Yuan, J. Q., Pentacyclic Triterpenoids from Leaves of Excoecaria agallocha. Chemical & Pharmaceutical Bulletin 2006, 54, (6), 920-921.
    連結:
  100. 137.Horiuchi, K.; Shiota, S.; Hatano, T.; Yoshida, T.; Kuroda, T.; Tsuchiya, T., Antimicrobial Activity of Oleanolic Acid from Salvia officinalis and Related Compounds on Vancomycin-Resistant Enterococci (VRE). Biological and Pharmaceutical Bulletin 2007, 30, (6), 1147-1149.
    連結:
  101. 138.Cipak, L.; Grausova, L.; Miadokova, E.; Novotny, L.; Rauko, P., Dual activity of triterpenoids: apoptotic versus antidifferentiation effects Archives of Toxicology 2006, 80, (7), 429-435.
    連結:
  102. 140.Son, J. K.; Jung, S. J.; Jung, J. H.; Fang, Z.; Lee, C. S.; Seo, C. S.; Moon, D. C.; Min, B. S.; Kim, M. R.; Woo, M. H., Anticancer Constituents from the Roots of Rubia cordifolia L. Chemical and Pharmaceutical Bulletin 2008, 56, (2), 213-216.
    連結:
  103. 141.Rodriguez-Rodriguez, R.; Stankevicius, E.; Herrera, M. D.; Østergaard, L.; Andersen, M. R.; Ruiz-Gutierrez, V.; Simonsen, U., Oleanolic acid induces relaxation and calcium-independent release of endothelium-derived nitric oxide. British Journal of Pharmacology 2008, 155, (4), 535-546.
    連結:
  104. 142.Takasaki, M.; Konoshima, T.; Tokuda, H.; Masuda, K.; Arai, Y.; Shiojima, K.; Ageta, H., Anti-carcinogenic Activity of Taraxacum Plant. II. Biological & Pharmaceutical Bulletin 1999, 22, (6), 606-610.
    連結:
  105. 143.Chaturvedula, V. S. P.; Schilling, J. K.; Malone, S.; Wisse, J. H.; Werkhoven, M. C. M.; Kingston, D. G. I., New Cytotoxic Triterpene Acids from Aboveground Parts of Manihot esculenta from the Suriname Rainforest. Planta Medica 2003, 69, (3), 271-274.
    連結:
  106. 144.Kanlayavattanakul, M.; Ruangrungsi, N.; Watanabe, T.; Kawahata, M.; Therrien, B.; Yamaguchi, K.; Ishikawa, T., ent-Halimane Diterpenes and a Guaiane Sesquiterpene from Cladogynos orientalis. Journal of Natural Products 2005, 68, (1), 7-10.
    連結:
  107. 145.Naik, D. G.; Mujumdar, A. M.; Waghole, R. J.; Misar, A. V.; Bligh, S. W. A.; Bashall, A.; Crowder, J., Taraxer-14-en-3β-ol, an Anti-Inflammatory Compound from Sterculia foetida L. Planta Medica 2004, 70, (1), 68-69.
    連結:
  108. 146.Duwiejua, M.; Zeitlin, I. J.; Gray, A. I.; Waterman, P. G., The Anti-Inflammatory Compounds of Polygonum bistorta: Isolation and Characterisation. Planta Medica 1999, 65, (4), 371-374.
    連結:
  109. 147.Choudhary, M. I.; Azizuddin; Jalil, S.; Atta-ur-Rahman, Bioactive phenolic compounds from a medicinal lichen, Usnea longissima Phytochemistry 2005, 66, (19), 2346-2350.
    連結:
  110. 148.Moiteiro, C.; Justino, F.; Tavares, R.; Marcelo-Curto, M. J.; Florêncio, M. H.; Nascimento, M. S. J.; Pedro, M.; Cerqueira, F.; Pinto, M. M. M., Synthetic Secofriedelane and Friedelane Derivatives as Inhibitors of Human Lymphocyte Proliferation and Growth of Human Cancer Cell Lines in Vitro. Journal of Natural Products 2001, 64, (10), 1273-1277.
    連結:
  111. 149.Reyes-Chilp, R.; Estrada-Muñiz, E.; Apan, T. R.; Amekraz, B.; Aumelas, A.; Jankowski, C. K.; Vázquez-Torres, M., Cytotoxic effects of mammea type coumarins from Calophyllum brasiliense. Life Sciences 2004, 75, (13), 1635-1647.
    連結:
  112. 150.Chang, K. C.; Duh, C. Y.; Chen, I. S.; Tsai, I. L., A Cytotoxic Butenolide, Two New Dolabellane Diterpenoids, a Chroman and a Benzoquinol Derivative Formosan Casearia membranacea. Planta Medica 2003, 69, (7), 667-672.
    連結:
  113. 151.Mitaine-Offer, A. C.; Sauvain, M.; Deharo, E.; Muñoz, V.; Zèches-Hanrot, M., A New Diterpene from Tanaecium jaroba. Planta Medica 2002, 68, 568-569.
    連結:
  114. 152.Lenta, B. N.; Devkota, K. P.; Ngouela, S.; Boyom, F. F.; Naz, Q.; Choudhary, M. I.; Tsamo, E.; Rosenthal, P. J.; Sewald, N., Anti-plasmodial and Cholinesterase Inhibiting Activities of some Constituents of Psorospermum glaberrimum. Chemical and Pharmaceutical Bulletin 2008, 56, (2), 222-226.
    連結:
  115. 153.Fukuda, T.; Ito, H.; Yoshida, T., Antioxidative polyphenols from walnuts (Juglans regia L.) Phytochemistry 2003, 63, (7), 795-801.
    連結:
  116. 154.Dong, H.; Chen, S. X.; Kini, R. M.; Xu, H. X., Effects of Tannins from Geum japonicum on the Catalytic Activity of Thrombin and Factor Xa of Blood Coagulation Cascade. Journal of Natural Products 1998, 61, (11), 1356-1360.
    連結:
  117. 155.Mook-Jung, I.; Kim, H.; Fan, W.; Tezuka, Y.; Kadota, S.; Nishijo, H.; Jung, M. W., Neuroprotective Effects of Constituents of the Oriental Crude Drugs, Rhodiola sacra, R. sachalinensis and Tokaku-joki-to, against Beta-amyloid Toxicity, Oxidative Stress and Apoptosis. Biological & Pharmaceutical Bulletin 2002, 25, (8), 1101-1104.
    連結:
  118. 156.Kurihara, H.; Shibata, H.; Fukui, Y.; Kiso, Y.; Xu, J. K.; Yao, X. S.; Fukami, H., Evaluation of the Hypolipemic Property of Camellia sinensis Var. ptilophylla on Postprandial Hypertriglyceridemia. Journal of Agricultural and Food Chemistry 2006, 54, (14), 4977-4981.
    連結:
  119. 157.Chen, W. J.; Chang, C. Y.; Lin, J. K., Induction of G1 phase arrest in MCF human breast cancer cells by pentagalloylglucose through the down-regulation of CDK4 and CDK2 activities and up-regulation of the CDK inhibitors p27Kip and p21Cip Biochemical Pharmacology 2003, 65, (11), 1777-1785.
    連結:
  120. 158.Ho, L. L.; Chen, W. J.; Lin-Shiau, S. Y.; Lin, J. K., Penta-O-galloyl-β-d-glucose inhibits the invasion of mouse melanoma by suppressing metalloproteinase-9 through down-regulation of activator protein-1 European Journal of Pharmacology 2002, 453, (2-3), 149-158.
    連結:
  121. 159.Lee, S. J.; Lee, H. K.; Jung, M. K.; Mar, W., In Vitro Antiviral Activity of 1,2,3,4,6-Penta-O-galloyl-β-D-glucose against Hepatitis B Virus. Biological & Pharmacetical Bulletin 2006, 29, (10), 2131-2134.
    連結:
  122. 160.Lee, S. H.; Park, H. H.; Kim, J. E.; Kim, J. A.; Kim, Y. H.; Jun, C. D.; Kim, S. H., Allose Gallates Suppress Expression of Pro-Inflammatory Cytokines through Attenuation of NF-κB in Human Mast Cells. Planta Medica 2007, 73, (8), 769-773.
    連結:
  123. 161.Valencia, E.; Valenzuela, E.; Barros, E.; Aedo, V.; Gebauer, M. T.; García, C.; González, A. G.; Bermejo, J., Constituents of Coriaria ruscifolia fruits Fitoterapia 2001, 72, (5), 555-557.
    連結:
  124. 162.Atta-Ur-Rahman; Ngounou, F. N.; Choudhary, M. I.; Malik, S.; Makhmoor, T.; Nur-E-Alam, M.; Zareen, S.; Lontsi, D.; Ayafor, J. F.; Sondengam, B. L., New Antioxidant and Antimicrobial Ellagic Acid Derivatives from Pteleopsis hylodendron. Planta Medica 2001, 67, (4), 335-339.
    連結:
  125. 164.Sinigaglia, M.; Lehmann, M.; Baumgardt, P.; Amaral, V. S. d.; Dihl, R. R.; Reguly, M. L.; Andrade, H. H. R. d., Vanillin as a modulator agent in SMART test: Inhibition in the steps that precede N-methyl-N-nitrosourea-, N-ethyl-N-nitrosourea-, ethylmethanesulphonate- and bleomycin-genotoxicity Mutation Research/Genetic Toxicology and Environmental Mutagenesis 2006, 607, (2), 225-230.
    連結:
  126. 165.Ueda, J. y.; Awale, S.; Tezuka, Y.; Shimamura, E.; Hirai, K. i.; Nobukawa, T.; Sato, A.; Kadota, S., Growth Inhibitory Activity of Wood of Taxus yunnanensis and its Liquid Chromatography Fourier-Transform Mass Spectrometry Analysis. Planta Medica 2006, 72, (13), 1241-1244.
    連結:
  127. 166.Lee, C. L.; Huang, P. C.; Hsieh, P. W.; Hwang, T. L.; Hou, Y. Y.; Chang, F. R.; Wu, Y. C., (-)-Xanthienopyran, a New Inhibitor of Superoxide Anion Generation by Activated Neutrophils, and Further Constituents of the Seeds of Xanthium strumarium. Planta Medica 2008, 74, (10), 1276-1279.
    連結:
  128. 168.Chen, J. J.; Chou, E. T.; Duh, C. Y.; Yang, S. Z.; Chen, I. S., New Cytotoxic Tetrahydrofuran- and Dihydrofuran-Type Lignans from the Stem of Beilschmiedia tsangii. Planta Medica 2006, 72, (4), 351-357.
    連結:
  129. 169.Harish, R.; Divakar, S.; Srivastava, A.; Shivanandappa, T., Isolation of Antioxidant Compounds from the Methanolic Extract of the Roots of Decalepis hamiltonii (Wight and Arn.). Journal of Agricultural and Food Chemistry 2005, 53, (20), 7709-7714.
    連結:
  130. 170.Kanegae, M. P. P.; Fonseca, L. M. d.; Brunetti, I. L.; Silva, S. d. O.; Ximenes, V. F., The reactivity of ortho-methoxy-substituted catechol radicals with sulfhydryl groups: Contribution for the comprehension of the mechanism of inhibition of NADPH oxidase by apocynin. Biochemical Pharmacology 2007, 74, (3), 457-464.
    連結:
  131. 171.Epifano, F.; Genovese, S.; Sosa, S.; Tubaro, A.; Curini, M., Synthesis and anti-inflammatory activity of 3-(4'-geranyloxy-3'-methoxyphenyl)-2-trans propenoic acid and its ester derivatives. Bioorganic and Medicinal Chemistry Letters 2007, 17, (20), 5709-5714.
    連結:
  132. 172.Fang, J. J.; Ye, G.; Chen, W. L.; Zhao, W. M., Antibacterial phenolic components from Eriocaulon buergerianum Phytochemistry 2008, 69, (5), 1279-1286.
    連結:
  133. 173.Tian, X. Y.; Wang, Y. H.; Liu, H. Y.; Yu, S. S.; Fang, W. S., On the Chemical Constituents of Dipsacus asper. Chemical and Pharmaceutical Bulletin 2007, 55, (12), 1677-1681.
    連結:
  134. 174.Yang, C.; Shi, Y. P.; Jia, Z. J., Sesquiterpene Lactone Glycosides, Eudesmanolides, and Other Constituents from Carpesium macrocephalum. Planta Medica 2002, 68, 626-630.
    連結:
  135. 175.Wu, T. S.; Shi, L. S.; Wang, J. J.; Iou, S. C.; Chang, H. C.; Chen, Y. P.; Kuo, Y. H.; Chang, Y. L.; Teng, C. M., Cytotoxic and Antiplatelet Aggregation Principles of Ruta graveolens. Journal of the Chinese Chemical Society 2003, 50, (1), 171-178.
    連結:
  136. 177.Dall'Acqua, S.; Viola, G.; Piacente, S.; Cappelletti, E. M.; Innocenti, G., Cytotoxic Constituents of Roots of Chaerophyllum hirsutum. Journal of Natural Products 2004, 67, (9), 1588-1590.
    連結:
  137. 179.Kim, E. K.; Kwon, K. B.; Shin, B. C.; Seo, E. A.; Lee, Y. R.; Kim, J. S.; Park, J. W.; Park, B. H.; Ryu, D. G., Scopoletin induces apoptosis in human promyeloleukemic cells, accompanied by activations of nuclear factor κB and caspase-3 Life Sciences 2005, 77, (7), 824-836.
    連結:
  138. 180.Chen, J. J.; Wang, T. Y.; Hwang, T. L., Neolignans, a Coumarinolignan, Lignan Derivatives, and a Chromene: Anti-inflammatory Constituents from Zanthoxylum avicennae. Journal of Natural Products 2008, 71, (2), 212-217.
    連結:
  139. 181.Felczak, K.; Drabikowska, A. K.; Vilpo, J. A.; Kulikowski, T.; Shugar, D., 6-Substituted and 5,6-Disubstituted Derivatives of Uridine: Stereoselective Synthesis, Interaction with Uridine Phosphorylase, and in Vitro Antitumor Activity. Journal of Medicinal Chemistry 1996, 39, (8), 1720-1728.
    連結:
  140. 182.Lee, C. L.; Chang, F. R.; Hsieh, P. W.; Chiang, M. Y.; Wu, C. C.; Huang, Z. Y.; Lan, Y. H.; Chen, M.; Lee, K. H.; Yen, H. F.; Hung, W. C.; Wu, Y. C., Cytotoxic ent-abietane diterpenes from Gelonium aequoreum. Phytochemistry 2008, 69, (1), 276-287.
    連結:
  141. 183.Shizuri, Y.; Kosemura, S.; Yamamura, S.; Ohba, S.; Ito, M.; Saito, Y., Isolation and Structures of Helioscopinolide, New Diterpenes from Euphorbia helioscopia L. Chemistry Letters 1983, 12, (1), 65-68.
    連結:
  142. 184.Crespi-Perellino, N.; Garofano, L.; Arlandini, E.; Pinciroli, V.; Minghetti, A.; Vincieri, F. F.; Danieli, B., Identification of New Diterpenoids from Euphorbia calyptrata Cell Cultures. Journal of Natural Products 1996, 59, (8), 773-776.
    連結:
  143. 185.Borghi, D.; Baumer, L.; Ballabio, M.; Arlandini, E.; Perellino, N. C.; Minghetti, A.; Vincieri, F. F., Structure Elucidation of Helioscopinolides D and E from Euphorbia calyptrata Cell Cultures. Journal of Natural Products 1991, 54, (6), 1503-1508.
    連結:
  144. 186.Yan, R. Y.; Tan, Y. X.; Cui, X. Q.; Chen, R. Y.; Yu, D. Q., Diterpenoids from the Roots of Suregada glomerulata. Journal of Natural Products 2008, 71, (2), 195-198.
    連結:
  145. 187.He, F.; Pu, J. X.; Huang, S. X.; Xiao, W. L.; Yang, L. B.; Li, X. N.; Zhao, Y.; Ding, J.; Xu, C. H.; Sun, H. D., Eight New Diterpenoids from the Roots of Euphorbia nematocypha. Helvetica Chimica Acta 2008, 91, (11), 2139-2147.
    連結:
  146. 189.Ageta, H.; Arai, Y.; Suzuki, H.; Kiyotani, T.; Kitabayashi, M., NMR Spectra of Triterpenoids. III. Oleanenes and Migrated Oleanenes. Chemical and Pharmaceutical Bulletin 1995, 43, (2), 198-203.
    連結:
  147. 190.Olea, R. S. G.; Torres, L. M. B.; Roque, L. C.; Roque, N. F., I3C NMR Spectroscopic Data for Glutinol and Derivatives. Magnetic Resonance in Chemistry 1994, 32, (6), 378-379.
    連結:
  148. 191.Antoniog.Gonzalez; Ferro, E.; Ravelo, A., Triterpenes from Maytenus horrida. Phytochemistry 1987, 26, (10), 2785-2788.
    連結:
  149. 192.Matsunaga, S.; Tanaka, R.; Akagi, M., Triterpenoids from Euphorbia maculata. Phytochemistry 1988, 27, (2), 535-537.
    連結:
  150. 193.Leong, Y. W.; Harrison, L. J., (20R,23E)-Eupha-8,23-diene-3β,25-diol from Tripetalum cymosum. Phytochemistry 1999, 50, (5), 849-857.
    連結:
  151. 196.Lee, S. C.; Kwon, Y. S.; Son, K. H.; Kim, H. P.; Heo, M. Y., Antioxidative Constituents from Paeonia lactiflora. Archives of Pharmacal Research 2005, 28, (7), 775-783.
    連結:
  152. 197.Vasconcelos, J. M. J.; Silva, A. M. S.; Cavaleiro, J. A. S., Chromones and flavanones from artemisia campestris subsp. maritima. Phytochemistry 1998, 49, (5), 1421-1424.
    連結:
  153. 198.Duarte, N. l.; Ferreira, M. J. U., Lagaspholones A and B: Two New Jatropholane-Type Diterpenes from Euphorbia lagascae. Organic Letters 2007, 9, (3), 489-492.
    連結:
  154. 199.Yang, S. W.; Cordell, G. A., Metabolism Studies of Indole Derivatives Using a Staurosporine Producer, Streptomyces staurosporeus. Journal of Natural Products 1997, 60, (1), 44-48.
    連結:
  155. 200.Asha, K. N.; Chowdhury, R.; Hasan, C. M.; Rashid, M. A., Steroids and polyketides from Uvaria hamiltonii stem bark. Acta Pharmaceutica 2004, 54, (57-63).
    連結:
  156. 201.Wright, J. L. C.; Mcinness, A. G.; Shimizu, S.; Smith, D. G.; Walter, J. A., Identification of C-24 alkyl epimers of marine sterols by 13C nuclear magnetic resonance spectroscopy. Canadian Journal of Chemistry 1978, 56, 1898-1903.
    連結:
  157. 202.Kontiza, I.; Abatis, D.; Malakate, K.; Vagias, C.; Roussis, V., 3-Keto steroids from the marine organisms Dendrophyllia cornigera and Cymodocea nodosa. Steroids 2006, 71, (2), 177-181.
    連結:
  158. 203.Kim, D. S.; Baek, N. l.; Oh, S. R.; Jung, K. Y.; Lee, I. S.; Kim, J. H.; Lee, H. K., Anticomplementary Activity of Ergosterol Peroxide from Naematoloma fasciculare and Reassignment of NMR Data. Archives of Pharmacal Research 1997, 20, (3), 201-205.
    連結:
  159. 204.Kuo, Y. H.; Lo, J. M.; Chan, Y. F., Cytotoxic Components from the Leaves of Schefflera taiwaniana. Journal of the Chinese Chemical Society 2002, 49, (3), 427-431.
    連結:
  160. 205.Kimura, J.; Maki, N., New Loliolide Derivatives from the Brown Alga Undaria pinnatifida. Journal of Natural Products 2002, 65, (1), 57-58.
    連結:
  161. 206.Wu, T. S.; Chang, F. C.; Wu, P. L.; Kuoh, C. S.; Chen, I. S., Constituents of Leaves of Tetradium glabrifolium. Journal of the Chinese Chemical Society 1995, 42, (6), 929-934.
    連結:
  162. 207.Tsai, I. L.; Jeng, Y. F.; Duh, C. Y.; Chen, I. S., Cytotoxic Constituents from the Leaves of Litsea akoensis. The Chinese Pharmaceutical Journal 2001, 53, 291-301.
    連結:
  163. 208.Min, Y. D.; Choi, S. U.; Lee, K. R., Aporphine Alkaloids and their Reversal Activity of Multidrug Resistance (MDR) from the Stems and Rhizomes of Sinomenium acutum. Archives of Pharmacal Research 2006, 29, (8), 627-632.
    連結:
  164. 209.Chiang, Y. M.; Liu, H. K.; Lo, J. M.; Chien, S. C.; Chan, Y. F.; Lee, T. H.; Su, J. K.; Kuo, Y. H., Cytotoxic Constituents of the Leaves of Calocedrus formosana. Journal of the Chinese Chemical Society 2003, 50, (1), 161-166.
    連結:
  165. 210.Wongsinkongman, P.; Brossi, A.; Wang, H. K.; Bastow, K. F.; Lee, K. H., Antitumor Agents. Part 209: Pheophorbide-a Derivatives as Photo-Independent Cytotoxic Agents. Bioorganic & Medicinal Chemistry 2002, 10, (3), 583-591.
    連結:
  166. 211.Cheng, H. H.; Wang, H. K.; Ito, J.; Bastow, K. F.; Tachibana, Y.; Nakanishi, Y.; Xu, Z.; Luo, T. Y.; Lee, K. H., Cytotoxic Pheophorbide-Related Compounds from Clerodendrum calamitosum and C. cyrtophyllum. Journal of Natural Products 2001, 64, (7), 915-919.
    連結:
  167. 212.Gogoi, S.; Argade, N. P., Synthesis of potassium 2,3,4-trihydroxy-2-methylbutanoate: a leaf-closing substance of Leucaena leucocephalam. Tetrahedron 2004, 60, (41), 9093-9093.
    連結:
  168. 213.Kis, K.; Wungsintaweekul, J.; Eisenreich, W.; Zenk, M. H.; Bacher, A., An Efficient Preparation of 2-C-Methyl-d-Erythritol 4-Phosphoric Acid and Its Derivatives. The Journal of Organic Chemistry 2000, 65, (2), 587-592.
    連結:
  169. 214.Fernandes, R. A.; Kumar, P., Enantioselective synthesis of (R)-(-)-mevalonolactone via cyclic sulfate methodology. Tetrahedron: Asymmetry 1999, 10, 4349-4356.
    連結:
  170. 215.Amagata, T.; Usami, Y.; Minoura, K.; Ito, T.; Numata, A., Cytotoxic Substances Produced by a Fungal Strain from a Sponge: Physico-chemical Properties and Structures. The Journal of Antibiotics 1998, 51, (1), 33-40.
    連結:
  171. 216.Eschenmoser, A.; Arigoni, D., Revisited after 50 Years: The 'Stereichemical Interpretation of the Biogenetic Isoprene Rule for the Triterpenes'. Helvetica Chimica Acta 2005, 88, (12), 3011-3050.
    連結:
  172. 1.鄭晴文, 日本抗老化市場發展現況及趨勢. 工業技術研究院 2008.
  173. 2.羅淑慧, 藥妝品之發展趨勢. ITIS 2003, 第四章.
  174. 3.李美賢, 中草藥功能性化妝品之應用開發. Yearbook of Chinese Medicine and Pharmacy 2007, 25, (1), 147-180.
  175. 4.Roy, C. R.; Gies, H. P.; Lugg, D. J.; Toomey, S.; Tomlinson, D. W., The measurement of solar ultraviolet radiation. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 1998, 422, (1), 7-14.
  176. 7.Stierner, U., Melanocytes, moles and melanoma: a study on UV effects. Acta dermato-venereologica. Supplementum 1991, 168, 1-31.
  177. 19.Pugliese, P. T., The skin's antioxidant systems. Dermatology Nursing 1998, 10, (6), 401-416.
  178. 21.Chung, J. H.; Seo, J. Y.; Choi, H. R.; Lee, M. K.; Youn, C. S.; Gi-eun Rhie; Cho, K. H.; Kim, K. H.; Park, K. C.; Eun, H. C., Modulation of Skin Collagen Metabolism in aged and photoaged human skin in vivo. The Journal of Investigative Dermatology 2001, 117, (5), 1218-1224.
  179. 22.Rabe, J. H.; Mamelak, A. J.; McElgunn, P. J. S.; Morison, W. L.; Sauder, D. N., Photoaging: Mechanisms and repair. Journal of the American Academy of Dermatology 2006, 55, (1), 20-21.
  180. 25.Scharffetter-Kochanek, K.; Wlaschek, M.; Brenneisen, P.; Schauen, M.; Blaudschun, R.; Wenk, J., UV-induced reactive oxygen species in photocarcinogenesis and photoaging. Biological Chemistry 1997, 378, (11), 1247-1257.
  181. 27.JuttaWenk; Brenneisen, P.; Meewes, C.; Wlaschek, M.; Peters, T.; Blaudschun, R.; Ma, W.; Kuhr, L.; Schneider, L.; Scharffetter-Kochanek, K., UV-induced oxidative stress and photoaging. Current Problems in Dermatology 2001, 29, 83-94.
  182. 30.Rømer, J.; Bugge, T. H.; Fyke, C.; Lund, L. R.; Flick, M. J.; Degen, J. L.; Danø, K., Impaired wound healing in mice with a disrupted plasminogen gene. Nature Medicine 1996, 2, 287-292.
  183. 33.Nagase, H., Zinc Metalloproteases in Health and Disease(Hooper, N. M., ed). Taylor and Francis London 1996, 153-204.
  184. 35.Martel-Pelletier, J.; McCollum, R.; Fujimoto, N.; Obata, K.; M.Cloutier, J.; Pelletier, J. P., Excess of metalloproteases over tissue inhibitor of metalloprotease may contribute to cartilage degradation in osteoarthritis and rheumatoid arthritis. Laboratory Investigation 1994, 70, (6), 807-815.
  185. 38.Lenz, O.; Elliot, S. J.; Stetler-Stevenson, W. G., Matrix Metalloproteinases in Renal Development and Disease Journal of the American Society of Nephrology 2000, 11, 574-581.
  186. 42.Ray, J. M.; Stetler-Stevenson, W. G., The role of matrix metalloproteases and their inhibitors in tumour invasion, metastasis and angiogenesis. European Respiratory Journal 1994, 7, 2062-2072.
  187. 59.Puente, X. S.; Pendás, A. M.; Llano, E.; Velasco, G.; López-Otín, C., Molecular cloning of a novel membrane-type matrix metalloproteinase from a human breast carcinoma. Cancer Research 1996, 56, (5), 944-949.
  188. 64.Somerville, R. P.; Oblander, S. A.; Apte, S. S., Matrix metalloproteinases: old dogs with new tricks. Genome Biology 2003, 4, (6), 216.
  189. 66.Welgus, H. G.; Stricklin, G. P.; Eisen, A. Z.; Bauer, E. A.; Cooney, R. V.; Jeffrey, J. J., A specific inhibitor of vertebrate collagenase produced by human skin fibroblasts. Journal of Biological Chemistry 1979, 254, (6), 1938-1943.
  190. 68.Oh, J.; Takahashi, R.; Kondo, S.; Mizoguchi, A.; Adachi, E.; Sasahara, R. M.; Nishimura, S.; Imamura, Y.; Kitayama, H.; Alexander, D. B.; Ide, C.; Horan, T. P.; Arakawa, T.; Yoshida, H.; Nishikawa, S. i.; Itoh, Y.; Seiki, M.; Itohara, S.; Takahashi, C.; Noda, M., The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis. Cell 2001, 107, (6), 789-800.
  191. 73.Gomez, D. E.; Alonso, D. F.; Yoshiji, H.; Thorgeirsson, U. P., Tissue inhibitors of metalloproteinases: structure, regulation and biological functions. European journal of cell biology 1997, 74, (2), 111-122.
  192. 76.R¨th, F. X. G.; Maskos, K.; Betz, M.; Bergner, A.; Huber, R.; Suzuki, K.; Yoshida, N.; Nagase, H.; Brew, K.; Bourenkov, G. P.; Bartunik, H.; Bode, W., Mechanism of inhibition of the human matrix metalloproteinase stromelysin-1 by TIMP-1. Nature 1997, 389, (4), 77-81.
  193. 78.李時珍, 本草綱目. 漢珍數位圖書公司 明代.
  194. 79.吳征鎰, 新華本草綱要. 上海科學技術出版社 1991, 第二冊.
  195. 80.李同琴; 郭秋紅; 田質芬, 大戟科植物藥用歷史沿革及價值的探討. 中醫藥學刊 2003, 21, (8), 1349-1350.
  196. 81.行政院衛生署中醫藥委員會, 臺灣藥用植物資源名錄. 2003, 285.
  197. 82.黃增泉; 耿煊; 謝萬權; 蔡進來; 胡哲明; 沈中桴; 楊國禎; 謝長富等, 台灣植物誌. Flora of Taiwan 1993, 3, 461.
  198. 89.Serkedjieva, J.; Gegova, G.; Mladenov, K., Protective efficacy of an aerosol preparation, obtained from Geranium sanguineum L., in experimental influenza infection. Pharmazie 2008, 63, (2), 160-163.
  199. 94.Wei, F.; Ma, S. C.; Ma, L. Y.; But, P. P. H.; Lin, R. C.; Khan, I. A., Antiviral Flavonoids from the Seeds of Aesculus chinensis. Journal of Natural Products 2004, 67, (4), 650-653.
  200. 103.TM, E.; AS, V., The inhibitory effect of curcumin, genistein, quercetin and cisplatin on the growth of oral cancer cells in vitro. Anticancer Research 2000, 20, (3A), 1733-1738.
  201. 104.Bravo, A.; Anacona, J. R., Metal complexes of the flavonoid quercetin: antibacterial properties Transition Metal Chemistry 2001, 26, (1-2), 20-23.
  202. 105.Aziz, N.; Farag, S.; Mousa, L.; Abo-Zaid, M., Comparative antibacterial and antifungal effects of some phenolic compounds Microbios 1998, 93, (374), 34-54.
  203. 108.Haraguchi, H.; Ishikawa, H.; Sanchez, Y.; Ogura, T.; Kubo, Y.; Kubo, I., Antioxidative constituents in Heterotheca inuloides Bioorganic and Medicinal Chemistry 1997, 5, (5), 865-871.
  204. 112.Ramiro, E.; Franch, À.; Castellote, C.; Pérez-Cano, F.; Permanyer, J.; Izquierdo-Pulido, M.; Castell, M., Flavonoids from Theobroma cacao Down-Regulate Inflammatory Mediators. Journal of Agricultural and Food Chemistry 2005, 53, (22), 8506-8511.
  205. 118.Quettier-Deleu, C.; Voiselle, G.; Fruchart, J. C.; Duriez, P.; Teissier, E.; Bailleul, F.; Vasseur, J.; Trotin, F., Hawthorn extracts inhibit LDL oxidation. Pharmazie 2003, 58, (8), 577-581.
  206. 122.Hernandez, J.; Goycoolea, F. M.; Quintero, J.; Acosta, A.; Castañeda, M.; Dominguez, Z.; Robles, R.; Vazquez-Moreno, L.; Velazquez, E. F.; Astiazaran, H.; Lugo, E.; Velazquez, C., Sonoran Propolis: Chemical Composition and Antiproliferative Activity on Cancer Cell Lines. Planta Medica 2007, 73, (14), 1469-1474.
  207. 123.Khushbaktova, Z. A.; Faizieva, S. K.; Syrov, V. N.; Yuldashev, M. P.; Batirov, É. K.; Mamatkhanov, A. U., Isolation, Chemical Analysis, and Study of the Hypolipidemic Activity of the Total Flavonoid Extract from Thermopsis altherniaflora Pharmaceutical Chemistry Journal 2001, 35, (3), 155-158.
  208. 136.Kuete, V.; Eyong, K. O.; Folefoc, G. N.; Beng, V. P.; Hussain, H.; Krohn, K.; Nkengfack, A. E., Antimicrobial activity of the methanolic extract and of the chemical constituents isolated from Newbouldia laevis. Pharmazie 2007, 62, (7), 552-556.
  209. 139.Fu, L.; Zhang, S.; Li, N.; Wang, J.; Zhao, M.; Sakai, J.; Hasegawa, T.; Mitsui, T.; Kataoka, T.; Oka, S.; Kiuchi, M.; Hirose, K.; Ando, M., Three New Triterpenes from Nerium oleander and Biological Activity of the Isolated Compounds. Journal of Natural Products 2005, 68, (2), 198-206.
  210. 163.Wang, R. F.; Xie, W. D.; Zhang, Z.; Xing, D. M.; Ding, Y.; Wang, W.; Ma, C.; Du, L. J., Bioactive Compounds from the Seeds of Punica granatum (Pomegranate). Journal of Natural Products 2004, 67, (12), 2096-2098.
  211. 167.Lirdprapamongkol, K.; Sakurai, H.; Kawasaki, N.; Choo, M.-K.; Saitoh, Y.; Aozuka, Y.; Singhirunnusorn, P.; Ruchirawat, S.; Svasti, J.; Saiki, I., Vanillin suppresses in vitro invasion and in vivo metastasis of mouse breast cancer cells. European Journal of Pharmaceutical Sciences 2005, 25, (1), 57-65.
  212. 176.Gu, J. Q.; Graf, T. N.; Lee, D.; Chai, H. B.; Mi, Q.; Kardono, L. B. S.; Setyowati, F. M.; Ismail, R.; Riswan, S.; Farnsworth, N. R.; Cordell, G. A.; Pezzuto, J. M.; Swanson, S. M.; Kroll, D. J.; Falkinham, J. O.; Wall, M. E.; Wani, M. C.; Kinghorn, A. D.; Oberlies, N. H., Cytotoxic and Antimicrobial Constituents of the Bark of Diospyros maritima Collected in Two Geographical Locations in Indonesia. Journal of Natural Products 2004, 67, (7), 1156-1161.
  213. 178.Abas, F.; Lajis, N. H.; Shaari, K.; Israf, D. A.; Stanslas, J.; Yusuf, U. K.; Raof, S. M., A Labdane Diterpene Glucoside from the Rhizomes of Curcuma mangga. Journal of Natural Products 2005, 68, (7), 1090-1093.
  214. 188.Jamal, A. K.; Yaacob, W. A.; Din, L. B., A Chemical Study on Phyllanthus Columnaris. European Journal of Scientific Research 2009, 28, (1), 76-81.
  215. 194.Lin, J. H.; Ku, Y. R.; Lin, Y. T.; Teng, S. F.; Wen, K. C.; Liao, C. H., Preparative Isolation and Gas Chromatography-Mass Spectrometry Analysis of Triterpenoids in Kansui Radix. Journal of Food and Drug Analysis 2000, 8, (4), 278-282.
  216. 195.Lavie, D.; Shvo, Y.; Glower, E., TERPENOIDS II - The Nuclear Magnetic Resonance Spectra of Tetracyclic Triterpenes. Tetrahedron 1963, 19, (12), 2255-2259.
  217. 217.Afshan, F., Studies on the chemical constituents of the leaves of Azadirachta indica (neem). H.E.J Research Institute Of Chemistry /University Of Karachi 2002, 1-184.