國人睡眠時數與代謝症候群盛行率之相關性探討

Study of Correlation between Sleep Duration and Metabolic Syndrome Prevalence in Taiwan

葉淑穎(Shu-Ying Yeh)

指導教授 ： 吳啟豪

共同指導教授 ： 劉珍芳(Jen-Fang Liu)

臺北醫學大學/公共衛生暨營養學院/保健營養學研究所/碩士(2015年)

https://doi.org/10.6831/TMU.2015.00068

摘要

睡眠時間的長短會影響人體內分泌的調節與激素的控制，當睡眠時數不足會增加罹患代謝症候群 （Metabolic syndrome, MS） 的風險，而代謝症候群與罹患心臟血管疾病風險更是有著正向的相關性。代謝症候群包括中央型肥胖、高血壓、高血糖及血脂異常等。文獻研究有關睡眠及代謝症候群的因果關係還不是很明確。本研究之目的為探討國人睡眠時數與代謝症候群發生因子之間的相關性。基礎資料收集乃採用2004-2008 年國民營養健康狀況變遷調查 (Nutrition and Health Survey in Taiwan, NAHSIT) 之問卷中，19 歲以上有回應問卷並參與體檢之 1613 位成年人之資料。實驗設計將受試者根據睡眠時數分為四組：≦6 小時睡眠時數組(≦6h）、6-7 小時睡眠時數組(6-7h）、 7-8 小時睡眠時數組(7-8h）與 ＞8 小時睡眠時數組(>8h），以瞭解不同睡眠時數之成年人對於代謝症候群發生的狀況。本研究結果顯示：在腰圍部分， 6-7h 睡眠時數組之腰圍顯著小於 ≦6h 及 >8h 睡眠時數組 (P=0.003)；HDL-C 方面， ≦6h 及 >8h 睡眠時數組有較低的 HDL-C (P=0.025) ；在空腹血糖值方面，≦6h 睡眠時數組顯著大於 6-7h 睡眠時數組與 >8h 睡眠時數組 (P=0.026) ；而 TG 方面，可觀察到 6-7h 及 7-8h 兩組之睡眠時數組顯著低於 ≦6h 及 >8h 睡眠時數組 (P=0.001)，亦有 U 形分布之趨勢；在罹患代謝症候群之代謝異常因子方面， 6-7h 睡眠時數組顯著低於 ≦6h 睡眠時數組其可能發生至少 1-3 項之代謝異常之高風險性 (P<0.05) 。因此本研究推論，國人平均睡眠時間為 6-7 小時時，相較於其它較短 (≦6h) 或較長 (>8h) 睡眠時數者其罹患代謝症候群的風險較低。

關鍵字

代謝症候群 ； 代謝症候群發生因子 ； 睡眠時數 ； 睡眠剝奪 ； NAHSIT

並列摘要

Background：Sleep exerts profound modulatory effect on the endocrine system, thereby affects the release of various hormones in the human body. Recent work indicates that sleep curtailment may adversely affect glucose tolerance and involve an increased risk of metabolic syndrome (MS) as well as for predisposition for cardiovascular disease. However, to date, literature about the causal relationship between sleep and MS is not very clear.
Aim: The objective of this study was to investigate the implications of sleep duration with regard to a clustering of MS risk factors including increased waist circumference, impaired fasting glucose, and abnormal levels of blood lipids in Taiwan.
Methods: The 2004-2008 Nutrition and Health Survey in Taiwan (NAHSIT) was carried out using stratified multi-stage sampling. The survey was conducted on adult members aged 19 years and above (n=1613). Participants were divided into 4 groups based upon their reported sleep duration as follow: (1) ≦6 h; (2) 6-7 h; (3) 7-8 h, and (4)＞8 h.
Results: The waist circumference in group 6-7h sleep duration was significantly less than groups ≦6h and >8h (P =0.003). Groups with ≦6h and >8h sleep duration had a lower high density lipoprotein-cholesterol (HDL-C) levels than others (P=0.025). The levels of fasting blood glucose were higher in group ≦6h than in groups 6-7 h and >8h (P=0.026). With respect to TG, the U-shaped distribution was observed that the levels of TG in groups 6-7h and 7-8h were significant lower than groups ≦6h and >8h (P=0.001). Therefore, the conclusions of this study, people in Taiwan average sleep duration was 6-7 hours, lower risk compared to other sleep duration longer or shorter were suffering from metabolic syndrome.

並列關鍵字

metabolic syndrome ； metabolic syndrome occurs factor ； the hours of sleep duration ； sleep deprivation ； NAHSIT

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