Title

胃癌發生及預後的分子標記研究

Translated Titles

Molecular Markers in the Development and Outcome of Gastric Cancer

Authors

李騰裕

Key Words

胃癌 ; 發生 ; 預後 ; 分子標記 ; Gastric cancer ; Development ; Outcome ; Molecular marker

PublicationName

中國醫藥大學臨床醫學研究所博士班 學位論文

Volume or Term/Year and Month of Publication

2014年

Academic Degree Category

博士

Advisor

吳俊穎

Content Language

繁體中文

Topic Category 醫藥衛生 > 社會醫學
醫學院 > 臨床醫學研究所博士班
Reference
  1. "The National Health Research Institutes of Taiwan. National Health Insurance Research Database. http://nhird.nhri.org.tw/en/."
    連結:
  2. Abnet, C. C., N. D. Freedman, F. Kamangar, M. F. Leitzmann, A. R. Hollenbeck and A. Schatzkin (2009). "Non-steroidal anti-inflammatory drugs and risk of gastric and oesophageal adenocarcinomas: results from a cohort study and a meta-analysis." Br J Cancer 100(3): 551-557.
    連結:
  3. Anzai, H., Y. Kitadai, C. D. Bucana, R. Sanchez, R. Omoto and I. J. Fidler (1998). "Expression of metastasis-related genes in surgical specimens of human gastric cancer can predict disease recurrence." Eur J Cancer 34(4): 558-565.
    連結:
  4. Areia, M., R. Carvalho, A. T. Cadime, F. Rocha Goncalves and M. Dinis-Ribeiro (2013). "Screening for gastric cancer and surveillance of premalignant lesions: a systematic review of cost-effectiveness studies." Helicobacter 18(5): 325-337.
    連結:
  5. Arjomandi, M., J. M. Galanter, S. Choudhry, C. Eng, D. Hu, K. Beckman, R. Chapela, J. R. Rodriguez-Santana, W. Rodriguez-Cintron, J. Ford, P. C. Avila and E. G. Burchard (2011). "Polymorphism in Osteopontin Gene (SPP1) Is Associated with Asthma and Related Phenotypes in a Puerto Rican Population." Pediatr Allergy Immunol Pulmonol 24(4): 207-214.
    連結:
  6. Awakura, Y., N. Ito, E. Nakamura, T. Takahashi, H. Kotani, Y. Mikami, T. Manabe, T. Kamoto, T. Habuchi and O. Ogawa (2006). "Matrix metalloproteinase-9 polymorphisms and renal cell carcinoma in a Japanese population." Cancer Lett 241(1): 59-63.
    連結:
  7. Beausoleil, M. S., E. B. Schulze, D. Goodale, C. O. Postenka and A. L. Allan (2011). "Deletion of the thrombin cleavage domain of osteopontin mediates breast cancer cell adhesion, proteolytic activity, tumorgenicity, and metastasis." BMC Cancer 11: 25.
    連結:
  8. Blankenberg, S., H. J. Rupprecht, O. Poirier, C. Bickel, M. Smieja, G. Hafner, J. Meyer, F. Cambien, L. Tiret and I. AtheroGene (2003). "Plasma concentrations and genetic variation of matrix metalloproteinase 9 and prognosis of patients with cardiovascular disease." Circulation 107(12): 1579-1585.
    連結:
  9. Boag, A. H. and I. D. Young (1993). "Immunohistochemical analysis of type IV collagenase expression in prostatic hyperplasia and adenocarcinoma." Mod Pathol 6(1): 65-68.
    連結:
  10. Breslin, N. P. and L. R. Sutherland (1999). "Survey of current practices among members of CAG in the follow-up of patients diagnosed with gastric ulcer." Can J Gastroenterol 13(6): 489-493.
    連結:
  11. Campo, E., M. J. Merino, F. A. Tavassoli, A. S. Charonis, W. G. Stetler-Stevenson and L. A. Liotta (1992). "Evaluation of basement membrane components and the 72 kDa type IV collagenase in serous tumors of the ovary." Am J Surg Pathol 16(5): 500-507.
    連結:
  12. Catarci, M., L. A. Montemurro, A. Di Cintio, S. Ghinassi, L. Coppola, L. Pinnarelli, A. Belardi, M. Koch and G. B. Grassi (2010). "Lymph node retrieval and examination during the implementation of extended lymph node dissection for gastric cancer in a non-specialized western institution." Updates Surg 62(2): 89-99.
    連結:
  13. Chang, W. L., H. B. Yang, H. C. Cheng, C. H. Chuang, P. J. Lu and B. S. Sheu (2011). "Increased gastric osteopontin expression by Helicobacter pylori Infection can correlate with more severe gastric inflammation and intestinal metaplasia." Helicobacter 16(3): 217-224.
    連結:
  14. Chen, L. T., J. T. Lin, R. Y. Shyu, C. M. Jan, C. L. Chen, I. P. Chiang, S. M. Liu, I. J. Su and A. L. Cheng (2001). "Prospective study of Helicobacter pylori eradication therapy in stage I(E) high-grade mucosa-associated lymphoid tissue lymphoma of the stomach." J Clin Oncol 19(22): 4245-4251.
    連結:
  15. Chiang, E. P., Y. C. Wang and F. Y. Tang (2007). "Folate restriction and methylenetetrahydrofolate reductase 677T polymorphism decreases adoMet synthesis via folate-dependent remethylation in human-transformed lymphoblasts." Leukemia 21(4): 651-658.
    連結:
  16. Chiocchetti, A., E. Orilieri, G. Cappellano, N. Barizzone, D. A. S, D. A. G, R. Lorini, R. Ravazzolo, F. Cadario, M. Martinetti, V. Calcaterra, F. Cerutti, G. Bruno, D. Larizza and U. Dianzani (2010). "The osteopontin gene +1239A/C single nucleotide polymorphism is associated with type 1 diabetes mellitus in the Italian population." Int J Immunopathol Pharmacol 23(1): 263-269.
    連結:
  17. Chiu, Y. W., H. F. Tu, I. K. Wang, C. H. Wu, K. W. Chang, T. Y. Liu and S. Y. Kao (2010). "The implication of osteopontin (OPN) expression and genetic polymorphisms of OPN promoter in oral carcinogenesis." Oral Oncol 46(4): 302-306.
    連結:
  18. Chu, D., Z. Zhang, Y. Li, J. Zheng, G. Dong, W. Wang and G. Ji (2011). "Matrix metalloproteinase-9 is associated with disease-free survival and overall survival in patients with gastric cancer." Int J Cancer 129(4): 887-895.
    連結:
  19. Committee, A. S. o. P., S. Banerjee, B. D. Cash, J. A. Dominitz, T. H. Baron, M. A. Anderson, T. Ben-Menachem, L. Fisher, N. Fukami, M. E. Harrison, S. O. Ikenberry, K. Khan, M. L. Krinsky, J. Maple, R. D. Fanelli and L. Strohmeyer (2010). "The role of endoscopy in the management of patients with peptic ulcer disease." Gastrointest Endosc 71(4): 663-668.
    連結:
  20. Dai, N., Q. Bao, A. Lu and J. Li (2007). "Protein expression of osteopontin in tumor tissues is an independent prognostic indicator in gastric cancer." Oncology 72(1-2): 89-96.
    連結:
  21. de las Fuentes, L., C. C. Gu, S. J. Mathews, J. L. Reagan, N. P. Ruthmann, A. D. Waggoner, C. F. Lai, D. A. Towler and V. G. Davila-Roman (2008). "Osteopontin promoter polymorphism is associated with increased carotid intima-media thickness." J Am Soc Echocardiogr 21(8): 954-960.
    連結:
  22. Duthie, S. J., S. Narayanan, S. Blum, L. Pirie and G. M. Brand (2000). "Folate deficiency in vitro induces uracil misincorporation and DNA hypomethylation and inhibits DNA excision repair in immortalized normal human colon epithelial cells." Nutr Cancer 37(2): 245-251.
    連結:
  23. Eckardt, V. F., W. Giessler, G. Kanzler and G. Bernhard (1992). "Does endoscopic follow-up improve the outcome of patients with benign gastric ulcers and gastric cancer?" Cancer 69(2): 301-305.
    連結:
  24. El Abiad, R. and H. Gerke (2012). "Gastric cancer: endoscopic diagnosis and staging." Surg Oncol Clin N Am 21(1): 1-19.
    連結:
  25. Fang, J. Y., S. D. Xiao, S. S. Zhu, J. M. Yuan, D. K. Qiu and S. J. Jiang (1997). "Relationship of plasma folic acid and status of DNA methylation in human gastric cancer." J Gastroenterol 32(2): 171-175.
    連結:
  26. Galvan-Portillo, M. V., L. F. Onate-Ocana, G. I. Perez-Perez, J. Chen, R. Herrera-Goepfert, L. Chihu-Amparan, L. Flores-Luna, A. Mohar-Betancourt and L. Lopez-Carrillo (2010). "Dietary folate and vitamin B12 intake before diagnosis decreases gastric cancer mortality risk among susceptible MTHFR 677TT carriers." Nutrition 26(2): 201-208.
    連結:
  27. Gao, B., T. Yasui, A. Okada, K. Tozawa, Y. Hayashi and K. Kohri (2005). "A polymorphism of the osteopontin gene is related to urinary calcium stones." J Urol 174(4 Pt 1): 1472-1476.
    連結:
  28. Giacopelli, F., R. Marciano, A. Pistorio, P. Catarsi, S. Canini, G. Karsenty and R. Ravazzolo (2004). "Polymorphisms in the osteopontin promoter affect its transcriptional activity." Physiol Genomics 20(1): 87-96.
    連結:
  29. Gogebakan, B., Y. Z. Igci, A. Arslan, M. Igci, S. Erturhan, S. Oztuzcu, H. Sen, S. Demiryurek, H. Arikoglu, B. Cengiz, R. Bayraktar, C. Yurtseven, K. Sarica and A. T. Demiryurek (2010). "Association between the T-593A and C6982T polymorphisms of the osteopontin gene and risk of developing nephrolithiasis." Arch Med Res 41(6): 442-448.
    連結:
  30. Gonda, T. A., Y. I. Kim, M. C. Salas, M. V. Gamble, W. Shibata, S. Muthupalani, K. J. Sohn, J. A. Abrams, J. G. Fox, T. C. Wang and B. Tycko (2012). "Folic acid increases global DNA methylation and reduces inflammation to prevent Helicobacter-associated gastric cancer in mice." Gastroenterology 142(4): 824-833 e827.
    連結:
  31. Gonzalez, C. A. and A. Agudo (2012). "Carcinogenesis, prevention and early detection of gastric cancer: where we are and where we should go." Int J Cancer 130(4): 745-753.
    連結:
  32. Gravalos, C. and A. Jimeno (2008). "HER2 in gastric cancer: a new prognostic factor and a novel therapeutic target." Ann Oncol 19(9): 1523-1529.
    連結:
  33. Grieu, F., W. Q. Li and B. Iacopetta (2004). "Genetic polymorphisms in the MMP-2 and MMP-9 genes and breast cancer phenotype." Breast Cancer Res Treat 88(3): 197-204.
    連結:
  34. Grivennikov, S. I. (2013). "IL-11: a prominent pro-tumorigenic member of the IL-6 family." Cancer Cell 24(2): 145-147.
    連結:
  35. Han, D. S., Y. S. Suh, S. H. Kong, H. J. Lee, Y. Choi, S. Aikou, T. Sano, B. J. Park, W. H. Kim and H. K. Yang (2012). "Nomogram predicting long-term survival after d2 gastrectomy for gastric cancer." J Clin Oncol 30(31): 3834-3840.
    連結:
  36. Hansson, L. E., O. Nyren, A. W. Hsing, R. Bergstrom, S. Josefsson, W. H. Chow, J. F. Fraumeni, Jr. and H. O. Adami (1996). "The risk of stomach cancer in patients with gastric or duodenal ulcer disease." N Engl J Med 335(4): 242-249.
    連結:
  37. Harrell, F. E., Jr., K. L. Lee and D. B. Mark (1996). "Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors." Stat Med 15(4): 361-387.
    連結:
  38. Hayasaka, A., N. Suzuki, N. Fujimoto, S. Iwama, E. Fukuyama, Y. Kanda and H. Saisho (1996). "Elevated plasma levels of matrix metalloproteinase-9 (92-kd type IV collagenase/gelatinase B) in hepatocellular carcinoma." Hepatology 24(5): 1058-1062.
    連結:
  39. Hermanek, P. (1995). "pTNM and residual tumor classifications: problems of assessment and prognostic significance." World J Surg 19(2): 184-190.
    連結:
  40. Hirabayashi, S., S. Kosugi, Y. Isobe, A. Nashimoto, I. Oda, K. Hayashi, I. Miyashiro, S. Tsujitani, Y. Kodera, Y. Seto, H. Furukawa, H. Ono, S. Tanabe, M. Kaminishi, S. Nunobe, T. Fukagawa, R. Matsuo, T. Nagai, H. Katai, T. Wakai and K. Akazawa (2014). "Development and external validation of a nomogram for overall survival after curative resection in serosa-negative, locally advanced gastric cancer." Ann Oncol 25(6): 1179-1184.
    連結:
  41. Hoikkala, S., P. Paakko, Y. Soini, R. Makitaro, V. Kinnula and T. Turpeenniemi-Hujanen (2006). "Tissue MMP-2 and MMP-9 [corrected] are better prognostic factors than serum MMP-2/TIMP-2--complex or TIMP-1 [corrected] in stage [corrected] I-III lung carcinoma." Cancer Lett 236(1): 125-132.
    連結:
  42. Hummelshoj, T., L. P. Ryder, H. O. Madsen, N. Odum and A. Svejgaard (2006). "A functional polymorphism in the Eta-1 promoter is associated with allele specific binding to the transcription factor Sp1 and elevated gene expression." Mol Immunol 43(7): 980-986.
    連結:
  43. Kattan, M. W., M. S. Karpeh, M. Mazumdar and M. F. Brennan (2003). "Postoperative nomogram for disease-specific survival after an R0 resection for gastric carcinoma." J Clin Oncol 21(19): 3647-3650.
    連結:
  44. Kim, K. Y., J. W. Lee, M. S. Park, M. H. Jung, G. A. Jeon and M. J. Nam (2006). "Expression of a thioredoxin-related protein-1 is induced by prostaglandin E(2)." Int J Cancer 118(7): 1670-1679.
    連結:
  45. Lagergren, J., A. Lindam and R. M. Mason (2012). "Gastric stump cancer after distal gastrectomy for benign gastric ulcer in a population-based study." Int J Cancer 131(6): E1048-1052.
    連結:
  46. Lahner, E., S. Persechino and B. Annibale (2012). "Micronutrients (Other than iron) and Helicobacter pylori infection: a systematic review." Helicobacter 17(1): 1-15.
    連結:
  47. Larsson, S. C., E. Giovannucci and A. Wolk (2006). "Folate intake, MTHFR polymorphisms, and risk of esophageal, gastric, and pancreatic cancer: a meta-analysis." Gastroenterology 131(4): 1271-1283.
    連結:
  48. Lee, C. W., B. Rickman, A. B. Rogers, Z. Ge, T. C. Wang and J. G. Fox (2008). "Helicobacter pylori eradication prevents progression of gastric cancer in hypergastrinemic INS-GAS mice." Cancer Res 68(9): 3540-3548.
    連結:
  49. Lee, K. H. and J. R. Kim (2012). "Regulation of HGF-mediated cell proliferation and invasion through NF-kappaB, JunB, and MMP-9 cascades in stomach cancer cells." Clin Exp Metastasis 29(3): 263-272.
    連結:
  50. Leung, W. K., S. R. Lin, J. Y. Ching, K. F. To, E. K. Ng, F. K. Chan, J. Y. Lau and J. J. Sung (2004). "Factors predicting progression of gastric intestinal metaplasia: results of a randomised trial on Helicobacter pylori eradication." Gut 53(9): 1244-1249.
    連結:
  51. Levy, A. T., V. Cioce, M. E. Sobel, S. Garbisa, W. F. Grigioni, L. A. Liotta and W. G. Stetler-Stevenson (1991). "Increased expression of the Mr 72,000 type IV collagenase in human colonic adenocarcinoma." Cancer Res 51(1): 439-444.
    連結:
  52. Li, Y., X. Jin, S. Kang, Y. Wang, H. Du, J. Zhang, W. Guo, N. Wang and S. Fang (2006). "Polymorphisms in the promoter regions of the matrix metalloproteinases-1, -3, -7, and -9 and the risk of epithelial ovarian cancer in China." Gynecol Oncol 101(1): 92-96.
    連結:
  53. Lindblad, M., L. A. Garcia Rodriguez, E. Chandanos and J. Lagergren (2006). "Hormone replacement therapy and risks of oesophageal and gastric adenocarcinomas." Br J Cancer 94(1): 136-141.
    連結:
  54. Lindzon, G. M., A. Medline, K. J. Sohn, F. Depeint, R. Croxford and Y. I. Kim (2009). "Effect of folic acid supplementation on the progression of colorectal aberrant crypt foci." Carcinogenesis 30(9): 1536-1543.
    連結:
  55. Liu, C. C., S. P. Huang, L. Y. Tsai, W. J. Wu, S. H. Juo, Y. H. Chou, C. H. Huang and M. T. Wu (2010). "The impact of osteopontin promoter polymorphisms on the risk of calcium urolithiasis." Clin Chim Acta 411(9-10): 739-743.
    連結:
  56. Llanos, O., S. Guzman and I. Duarte (1982). "Accuracy of the first endoscopic procedure in the differential diagnosis of gastric lesions." Ann Surg 195(2): 224-226.
    連結:
  57. Maetzler, W., J. Michelis, J. Tomiuk, A. Melms, C. Becker, T. Gasser, C. Schulte and D. Berg (2009). "A single-nucleotide polymorphism of the osteopontin gene may contribute to a susceptibility to Lewy body disease." J Neural Transm 116(5): 599-605.
    連結:
  58. Matsumura, S., N. Oue, H. Nakayama, Y. Kitadai, K. Yoshida, Y. Yamaguchi, K. Imai, K. Nakachi, K. Matsusaki, K. Chayama and W. Yasui (2005). "A single nucleotide polymorphism in the MMP-9 promoter affects tumor progression and invasive phenotype of gastric cancer." J Cancer Res Clin Oncol 131(1): 19-25.
    連結:
  59. Nagase, H. and J. F. Woessner, Jr. (1999). "Matrix metalloproteinases." J Biol Chem 274(31): 21491-21494.
    連結:
  60. Naito, M., A. Matsui, M. Inao, S. Nagoshi, M. Nagano, N. Ito, T. Egashira, M. Hashimoto, S. Mishiro, S. Mochida and K. Fujiwara (2005). "SNPs in the promoter region of the osteopontin gene as a marker predicting the efficacy of interferon-based therapies in patients with chronic hepatitis C." J Gastroenterol 40(4): 381-388.
    連結:
  61. Nakayama, H., H. Nagai, K. Matsumoto, R. Oguro, K. Sugimoto, K. Kamide, M. Ohishi, T. Katsuya, H. Okamoto, M. Maeda, K. Komamura, J. Azuma, H. Rakugi and Y. Fujio (2011). "Association between osteopontin promoter variants and diastolic dysfunction in hypertensive heart in the Japanese population." Hypertens Res 34(10): 1141-1146.
    連結:
  62. Neuhouser, M. L., H. F. Nijhout, J. F. Gregory, 3rd, M. C. Reed, S. J. James, A. Liu, B. Shane and C. M. Ulrich (2011). "Mathematical modeling predicts the effect of folate deficiency and excess on cancer-related biomarkers." Cancer Epidemiol Biomarkers Prev 20(9): 1912-1917.
    連結:
  63. O'Broin, S. and B. Kelleher (1992). "Microbiological assay on microtitre plates of folate in serum and red cells." J Clin Pathol 45(4): 344-347.
    連結:
  64. Oh, S. Y., H. C. Kwon, S. H. Kim, S. Lee, J. H. Lee, C. A. Graves, K. Camphausen and H. J. Kim (2012). "Prognostic significance of serum levels of vascular endothelial growth factor and insulin-like growth factor-1 in advanced gastric cancer patients treated with FOLFOX chemotherapy." Chemotherapy 58(6): 426-434.
    連結:
  65. Pelucchi, C., I. Tramacere, P. Bertuccio, A. Tavani, E. Negri and C. La Vecchia (2009). "Dietary intake of selected micronutrients and gastric cancer risk: an Italian case-control study." Ann Oncol 20(1): 160-165.
    連結:
  66. Peng, B., L. Cao, X. Ma, W. Wang, D. Wang and L. Yu (2010). "Meta-analysis of association between matrix metalloproteinases 2, 7 and 9 promoter polymorphisms and cancer risk." Mutagenesis 25(4): 371-379.
    連結:
  67. Podolsky, I., P. R. Storms, C. T. Richardson, W. L. Peterson and J. S. Fordtran (1988). "Gastric adenocarcinoma masquerading endoscopically as benign gastric ulcer. A five-year experience." Dig Dis Sci 33(9): 1057-1063.
    連結:
  68. Pruitt, R. E. and C. D. Truss (1993). "Endoscopy, gastric ulcer, and gastric cancer. Follow-up endoscopy for all gastric ulcers?" Dig Dis Sci 38(2): 284-288.
    連結:
  69. Roukos, D. H. (2000). "Current status and future perspectives in gastric cancer management." Cancer Treat Rev 26(4): 243-255.
    連結:
  70. Said, H. M. (2011). "Intestinal absorption of water-soluble vitamins in health and disease." Biochem J 437(3): 357-372.
    連結:
  71. Saini, S. D., G. Eisen, N. Mattek and P. Schoenfeld (2008). "Utilization of upper endoscopy for surveillance of gastric ulcers in the United States." Am J Gastroenterol 103(8): 1920-1925.
    連結:
  72. Sakaki, M., R. Makino, K. Hiroishi, K. Ueda, J. Eguchi, A. Hiraide, H. Doi, R. Omori and M. Imawari (2010). "Cyclooxygenase-2 gene promoter polymorphisms affect susceptibility to hepatitis C virus infection and disease progression." Hepatol Res 40(12): 1219-1226.
    連結:
  73. Salamonsen, L. A., A. R. Butt, F. R. Hammond, S. Garcia and J. Zhang (1997). "Production of endometrial matrix metalloproteinases, but not their tissue inhibitors, is modulated by progesterone withdrawal in an in vitro model for menstruation." J Clin Endocrinol Metab 82(5): 1409-1415.
    連結:
  74. Santos, F. C., S. S. Rochel-Maia, R. A. Fochi, L. A. Justulin, Jr., S. A. Santos, P. S. Vilamaior, S. L. Felisbino, R. M. Goes and S. R. Taboga (2011). "MMP-2 and MMP-9 localization and activity in the female prostate during estrous cycle." Gen Comp Endocrinol 173(3): 419-427.
    連結:
  75. Sauerbrei, W. and M. Schumacher (1992). "A bootstrap resampling procedure for model building: application to the Cox regression model." Stat Med 11(16): 2093-2109.
    連結:
  76. Schultz, J., P. Lorenz, S. M. Ibrahim, G. Kundt, G. Gross and M. Kunz (2009). "The functional -443T/C osteopontin promoter polymorphism influences osteopontin gene expression in melanoma cells via binding of c-Myb transcription factor." Mol Carcinog 48(1): 14-23.
    連結:
  77. Seidl, C., M. Port, K. P. Gilbertz, A. Morgenstern, F. Bruchertseifer, M. Schwaiger, B. Roper, R. Senekowitsch-Schmidtke and M. Abend (2007). "213Bi-induced death of HSC45-M2 gastric cancer cells is characterized by G2 arrest and up-regulation of genes known to prevent apoptosis but induce necrosis and mitotic catastrophe." Mol Cancer Ther 6(8): 2346-2359.
    連結:
  78. Shaheen, N. J., W. L. Straus and R. S. Sandler (2002). "Chemoprevention of gastrointestinal malignancies with nonsteroidal antiinflammatory drugs." Cancer 94(4): 950-963.
    連結:
  79. Shang, S., A. Plymoth, S. Ge, Z. Feng, H. R. Rosen, S. Sangrajrang, P. Hainaut, J. A. Marrero and L. Beretta (2012). "Identification of osteopontin as a novel marker for early hepatocellular carcinoma." Hepatology 55(2): 483-490.
    連結:
  80. Shin, C. M., N. Kim, H. S. Lee, H. E. Lee, S. H. Lee, Y. S. Park, J. H. Hwang, J. W. Kim, S. H. Jeong, D. H. Lee, H. C. Jung and I. S. Song (2009). "Validation of diagnostic tests for Helicobacter pylori with regard to grade of atrophic gastritis and/or intestinal metaplasia." Helicobacter 14(6): 512-519.
    連結:
  81. Shojaei, F., N. Scott, X. Kang, P. B. Lappin, A. A. Fitzgerald, S. Karlicek, B. H. Simmons, A. Wu, J. H. Lee, S. Bergqvist and E. Kraynov (2012). "Osteopontin induces growth of metastatic tumors in a preclinical model of non-small lung cancer." J Exp Clin Cancer Res 31: 26.
    連結:
  82. Sipponen, P. and P. Correa (2002). "Delayed rise in incidence of gastric cancer in females results in unique sex ratio (M/F) pattern: etiologic hypothesis." Gastric Cancer 5(4): 213-219.
    連結:
  83. Sohn, K. J., H. Jang, M. Campan, D. J. Weisenberger, J. Dickhout, Y. C. Wang, R. C. Cho, Z. Yates, M. Lucock, E. P. Chiang, R. C. Austin, S. W. Choi, P. W. Laird and Y. I. Kim (2009). "The methylenetetrahydrofolate reductase C677T mutation induces cell-specific changes in genomic DNA methylation and uracil misincorporation: a possible molecular basis for the site-specific cancer risk modification." Int J Cancer 124(9): 1999-2005.
    連結:
  84. Song, G., G. Ouyang, Y. Mao, Y. Ming, S. Bao and T. Hu (2009). "Osteopontin promotes gastric cancer metastasis by augmenting cell survival and invasion through Akt-mediated HIF-1alpha up-regulation and MMP9 activation." J Cell Mol Med 13(8B): 1706-1718.
    連結:
  85. Song, J., A. Medline, J. B. Mason, S. Gallinger and Y. I. Kim (2000). "Effects of dietary folate on intestinal tumorigenesis in the apcMin mouse." Cancer Res 60(19): 5434-5440.
    連結:
  86. Stempak, J. M., K. J. Sohn, E. P. Chiang, B. Shane and Y. I. Kim (2005). "Cell and stage of transformation-specific effects of folate deficiency on methionine cycle intermediates and DNA methylation in an in vitro model." Carcinogenesis 26(5): 981-990.
    連結:
  87. Sun, L., J. Pan, L. Peng, L. Fang, X. Zhao, L. Sun, Z. Yang and Y. Ran (2012). "Combination of haptoglobin and osteopontin could predict colorectal cancer hepatic metastasis." Ann Surg Oncol 19(7): 2411-2419.
    連結:
  88. Sun, L., Y. H. Sun, B. Wang, H. Y. Cao and C. Yu (2008). "Methylenetetrahydrofolate reductase polymorphisms and susceptibility to gastric cancer in Chinese populations: a meta-analysis." Eur J Cancer Prev 17(5): 446-452.
    連結:
  89. Tan, W., X. Miao, L. Wang, C. Yu, P. Xiong, G. Liang, T. Sun, Y. Zhou, X. Zhang, H. Li and D. Lin (2005). "Significant increase in risk of gastroesophageal cancer is associated with interaction between promoter polymorphisms in thymidylate synthase and serum folate status." Carcinogenesis 26(8): 1430-1435.
    連結:
  90. Wagner, A. D., W. Grothe, J. Haerting, G. Kleber, A. Grothey and W. E. Fleig (2006). "Chemotherapy in advanced gastric cancer: a systematic review and meta-analysis based on aggregate data." J Clin Oncol 24(18): 2903-2909.
    連結:
  91. Wang, T. P., S. H. Hsu, H. C. Feng and R. F. Huang (2012). "Folate deprivation enhances invasiveness of human colon cancer cells mediated by activation of sonic hedgehog signaling through promoter hypomethylation and cross action with transcription nuclear factor-kappa B pathway." Carcinogenesis 33(6): 1158-1168.
    連結:
  92. Wang, W. H., J. Q. Huang, G. F. Zheng, S. K. Lam, J. Karlberg and B. C. Wong (2003). "Non-steroidal anti-inflammatory drug use and the risk of gastric cancer: a systematic review and meta-analysis." J Natl Cancer Inst 95(23): 1784-1791.
    連結:
  93. Wang, Y., S. Fang, L. Wei, R. Wang, X. Jin, D. Wen, Y. Li, W. Guo, N. Wang and J. Zhang (2005). "No association between the C-1562T polymorphism in the promoter of matrix metalloproteinase-9 gene and non-small cell lung carcinoma." Lung Cancer 49(2): 155-161.
    連結:
  94. Watanabe, T., M. Tada, H. Nagai, S. Sasaki and M. Nakao (1998). "Helicobacter pylori infection induces gastric cancer in mongolian gerbils." Gastroenterology 115(3): 642-648.
    連結:
  95. Weng, Y. R., D. F. Sun, J. Y. Fang, W. Q. Gu and H. Y. Zhu (2006). "Folate levels in mucosal tissue but not methylenetetrahydrofolate reductase polymorphisms are associated with gastric carcinogenesis." World J Gastroenterol 12(47): 7591-7597.
    連結:
  96. Wu, C. Y., K. N. Kuo, M. S. Wu, Y. J. Chen, C. B. Wang and J. T. Lin (2009). "Early Helicobacter pylori eradication decreases risk of gastric cancer in patients with peptic ulcer disease." Gastroenterology 137(5): 1641-1648 e1641-1642.
    連結:
  97. Wu, C. Y., M. S. Wu, E. P. Chiang, C. C. Wu, Y. J. Chen, C. J. Chen, N. H. Chi, G. H. Chen and J. T. Lin (2007). "Elevated plasma osteopontin associated with gastric cancer development, invasion and survival." Gut 56(6): 782-789.
    連結:
  98. Wu, K., Y. Nie, C. Guo, Y. Chen, J. Ding and D. Fan (2009). "Molecular basis of therapeutic approaches to gastric cancer." J Gastroenterol Hepatol 24(1): 37-41.
    連結:
  99. Wu, M. S., C. T. Shun, H. P. Wang, J. C. Sheu, W. J. Lee, T. H. Wang and J. T. Lin (1997). "Genetic alterations in gastric cancer: relation to histological subtypes, tumor stage, and Helicobacter pylori infection." Gastroenterology 112(5): 1457-1465.
    連結:
  100. Wu, M. S., C. Y. Wu, C. J. Chen, M. T. Lin, C. T. Shun and J. T. Lin (2003). "Interleukin-10 genotypes associate with the risk of gastric carcinoma in Taiwanese Chinese." Int J Cancer 104(5): 617-623.
    連結:
  101. Xiao, Q., N. D. Freedman, J. Ren, A. R. Hollenbeck, C. C. Abnet and Y. Park (2014). "Intakes of folate, methionine, vitamin B6, and vitamin B12 with risk of esophageal and gastric cancer in a large cohort study." Br J Cancer 110(5): 1328-1333.
    連結:
  102. Xu, A. P., J. Bai, J. Lu, Y. Y. Liang, J. G. Li, D. Y. Lai, X. Wan and H. H. Huang (2007). "Osteopontin gene polymorphism in association with systemic lupus erythematosus in Chinese patients." Chin Med J (Engl) 120(23): 2124-2128.
    連結:
  103. Yang, H. I., M. Sherman, J. Su, P. J. Chen, Y. F. Liaw, U. H. Iloeje and C. J. Chen (2010). "Nomograms for risk of hepatocellular carcinoma in patients with chronic hepatitis B virus infection." J Clin Oncol 28(14): 2437-2444.
    連結:
  104. You, W. C., L. M. Brown, L. Zhang, J. Y. Li, M. L. Jin, Y. S. Chang, J. L. Ma, K. F. Pan, W. D. Liu, Y. Hu, S. Crystal-Mansour, D. Pee, W. J. Blot, J. F. Fraumeni, Jr., G. W. Xu and M. H. Gail (2006). "Randomized double-blind factorial trial of three treatments to reduce the prevalence of precancerous gastric lesions." J Natl Cancer Inst 98(14): 974-983.
    連結:
  105. Zhang, B., S. Ye, S. M. Herrmann, P. Eriksson, M. de Maat, A. Evans, D. Arveiler, G. Luc, F. Cambien, A. Hamsten, H. Watkins and A. M. Henney (1999). "Functional polymorphism in the regulatory region of gelatinase B gene in relation to severity of coronary atherosclerosis." Circulation 99(14): 1788-1794.
    連結:
  106. Zhou, J. Y., R. Shi, H. L. Yu, Y. Zeng, W. L. Zheng and W. L. Ma (2012). "The association between two polymorphisms in the TS gene and risk of cancer: a systematic review and pooled analysis." Int J Cancer 131(9): 2103-2116.
    連結:
  107. Barizzone, N., M. Marchini, F. Cappiello, A. Chiocchetti, E. Orilieri, D. Ferrante, L. Corrado, S. Mellone, R. Scorza, U. Dianzani and S. D'Alfonso (2011). "Association of osteopontin regulatory polymorphisms with systemic sclerosis." Hum Immunol 72(10): 930-934.
  108. Boccia, S., R. Hung, G. Ricciardi, F. Gianfagna, M. P. Ebert, J. Y. Fang, C. M. Gao, T. Gotze, F. Graziano, M. Lacasana-Navarro, D. Lin, L. Lopez-Carrillo, Y. L. Qiao, H. Shen, R. Stolzenberg-Solomon, T. Takezaki, Y. R. Weng, F. F. Zhang, C. M. van Duijn, P. Boffetta and E. Taioli (2008). "Meta- and pooled analyses of the methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and gastric cancer risk: a huge-GSEC review." Am J Epidemiol 167(5): 505-516.
  109. Cohen, J., M. A. Safdi, S. E. Deal, T. H. Baron, A. Chak, B. Hoffman, B. C. Jacobson, K. Mergener, B. T. Petersen, J. L. Petrini, D. K. Rex, D. O. Faigel and I. M. Pike (2006). "Quality indicators for esophagogastroduodenoscopy." Gastrointest Endosc 63(4 Suppl): S10-15.
  110. Endo, K., Y. Maehara, H. Baba, M. Yamamoto, S. Tomisaki, A. Watanabe, Y. Kakeji and K. Sugimachi (1997). "Elevated levels of serum and plasma metalloproteinases in patients with gastric cancer." Anticancer Res 17(3C): 2253-2258.
  111. Harrell, F. E., Jr., R. M. Califf, D. B. Pryor, K. L. Lee and R. A. Rosati (1982). "Evaluating the yield of medical tests." JAMA 247(18): 2543-2546.
  112. Hou, L., E. M. El-Omar, J. Chen, P. Grillo, C. S. Rabkin, A. Baccarelli, M. Yeager, S. J. Chanock, W. Zatonski, L. H. Sobin, J. Lissowska, J. F. Fraumeni, Jr. and W. H. Chow (2007). "Polymorphisms in Th1-type cell-mediated response genes and risk of gastric cancer." Carcinogenesis 28(1): 118-123.
  113. Imano, M., T. Satou, T. Itoh, K. Sakai, E. Ishimaru, A. Yasuda, Y. F. Peng, M. Shinkai, F. Akai, T. Yasuda, H. Imamoto, K. Okuno, H. Ito, H. Shiozaki and H. Ohyanagi (2009). "Immunohistochemical expression of osteopontin in gastric cancer." J Gastrointest Surg 13(9): 1577-1582.
  114. Iwaya, Y., T. Akamatsu, T. Ito, T. Nagaya, T. Suga and N. Arakura (2010). "[Differential diagnosis of gastric ulcer and gastric cancer in elderly patients]." Nihon Rinsho 68(11): 2036-2039.
  115. Jemal, A., F. Bray, M. M. Center, J. Ferlay, E. Ward and D. Forman (2011). "Global cancer statistics." CA Cancer J Clin 61(2): 69-90.
  116. Kim, Y. I. (2004). "Folate and DNA methylation: a mechanistic link between folate deficiency and colorectal cancer?" Cancer Epidemiol Biomarkers Prev 13(4): 511-519.
  117. Kubben, F. J., C. F. Sier, M. J. Meijer, M. van den Berg, J. J. van der Reijden, G. Griffioen, C. J. van de Velde, C. B. Lamers and H. W. Verspaget (2006). "Clinical impact of MMP and TIMP gene polymorphisms in gastric cancer." Br J Cancer 95(6): 744-751.
  118. Leung, W. K., M. S. Wu, Y. Kakugawa, J. J. Kim, K. G. Yeoh, K. L. Goh, K. C. Wu, D. C. Wu, J. Sollano, U. Kachintorn, T. Gotoda, J. T. Lin, W. C. You, E. K. Ng, J. J. Sung and C. Asia Pacific Working Group on Gastric (2008). "Screening for gastric cancer in Asia: current evidence and practice." Lancet Oncol 9(3): 279-287.
  119. Liu, N., K. Zhang and H. Zhao (2008). "Haplotype-association analysis." Adv Genet 60: 335-405.
  120. Malfertheiner, P., F. Megraud, C. A. O'Morain, J. Atherton, A. T. Axon, F. Bazzoli, G. F. Gensini, J. P. Gisbert, D. Y. Graham, T. Rokkas, E. M. El-Omar, E. J. Kuipers and G. European Helicobacter Study (2012). "Management of Helicobacter pylori infection--the Maastricht IV/ Florence Consensus Report." Gut 61(5): 646-664.
  121. Pegoraro, E., E. P. Hoffman, L. Piva, B. F. Gavassini, S. Cagnin, M. Ermani, L. Bello, G. Soraru, B. Pacchioni, M. D. Bonifati, G. Lanfranchi, C. Angelini, A. Kesari, I. Lee, H. Gordish-Dressman, J. M. Devaney, C. M. McDonald and G. Cooperative International Neuromuscular Research (2011). "SPP1 genotype is a determinant of disease severity in Duchenne muscular dystrophy." Neurology 76(3): 219-226.
  122. Putoczki, T. L., S. Thiem, A. Loving, R. A. Busuttil, N. J. Wilson, P. K. Ziegler, P. M. Nguyen, A. Preaudet, R. Farid, K. M. Edwards, Y. Boglev, R. B. Luwor, A. Jarnicki, D. Horst, A. Boussioutas, J. K. Heath, O. M. Sieber, I. Pleines, B. T. Kile, A. Nash, F. R. Greten, B. S. McKenzie and M. Ernst (2013). "Interleukin-11 is the dominant IL-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically." Cancer Cell 24(2): 257-271.
  123. Song, J., K. J. Sohn, A. Medline, C. Ash, S. Gallinger and Y. I. Kim (2000). "Chemopreventive effects of dietary folate on intestinal polyps in Apc+/-Msh2-/- mice." Cancer Res 60(12): 3191-3199.
  124. Torii, A., Y. Kodera, K. Uesaka, T. Hirai, K. Yasui, T. Morimoto, Y. Yamamura, T. Kato, T. Hayakawa, N. Fujimoto and T. Kito (1997). "Plasma concentration of matrix metalloproteinase 9 in gastric cancer." Br J Surg 84(1): 133-136.
  125. Vollset, S. E., J. Igland, M. Jenab, A. Fredriksen, K. Meyer, S. Eussen, H. K. Gjessing, P. M. Ueland, G. Pera, N. Sala, A. Agudo, G. Capella, G. Del Giudice, D. Palli, H. Boeing, C. Weikert, H. B. Bueno-de-Mesquita, F. Carneiro, V. Pala, P. Vineis, R. Tumino, S. Panico, G. Berglund, J. Manjer, R. Stenling, G. Hallmans, C. Martinez, M. Dorronsoro, A. Barricarte, C. Navarro, J. R. Quiros, N. Allen, T. J. Key, S. Bingham, J. Linseisen, R. Kaaks, K. Overvad, A. Tjonneland, F. L. Buchner, P. H. Peeters, M. E. Numans, F. Clavel-Chapelon, M. C. Boutron-Ruault, A. Trichopoulou, E. Lund, N. Slimani, P. Ferrari, E. Riboli and C. A. Gonzalez (2007). "The association of gastric cancer risk with plasma folate, cobalamin, and methylenetetrahydrofolate reductase polymorphisms in the European Prospective Investigation into Cancer and Nutrition." Cancer Epidemiol Biomarkers Prev 16(11): 2416-2424.
  126. Weber, G. F. (2011). "The cancer biomarker osteopontin: combination with other markers." Cancer Genomics Proteomics 8(6): 263-288.
  127. Xu, E. P., Q. Huang, B. J. Lu, X. M. Xing and M. D. Lai (2006). "[The correlation between polymorphisms of matrix metalloproteinase-2 and -9 genes and colorectal cancer of Chinese patients]." Zhonghua Yi Xue Yi Chuan Xue Za Zhi 23(1): 78-81.
  128. Zhang, X. M., X. P. Miao, P. Xiong, C. Y. Yu, W. Tan, S. N. Qu, T. Sun, Y. F. Zhou and D. X. Lin (2004). "[Association of functional polymorphisms in matrix metalloproteinase-2 (MMP-2) and MMP-9 genes with risk of gastric cancer in a Chinese population]." Ai Zheng 23(11): 1233-1237.
  129. Zucker, S., R. M. Lysik, M. H. Zarrabi and U. Moll (1993). "M(r) 92,000 type IV collagenase is increased in plasma of patients with colon cancer and breast cancer." Cancer Res 53(1): 140-146.