Title

探討骨質密度與心臟血管疾病之相關性---以埔里地區居民為例

Translated Titles

Correlation of Bone Mineral Density and Cardiovascular Disease in Pu Li Township

DOI

10.6830/CMU.2008.00017

Authors

黃揆洲

Key Words

骨質疏鬆症 ; 超音波骨密測量儀(QUS) ; 心血管疾病 ; 骨質密度 ; Osteoporosis, QUS ; cardiovascular disease ; bone mineral density

PublicationName

中國醫藥大學醫務管理學系碩士班學位論文

Volume or Term/Year and Month of Publication

2008年

Academic Degree Category

碩士

Advisor

蔡文正

Content Language

繁體中文

Chinese Abstract

目的:有研究顯示骨質疏鬆症與心血管疾病之間有關聯性,但目前國内有關這兩者之間流行病學的相關性研究不多。因此本研究透過流行病學調查以及超音波骨質密度檢測,以了解骨質密度低下的盛行率、危險因子,以及與心血管疾病之間的關係。方法:以橫斷式研究,在埔里地區,分層抽樣50歲以上之居民,並透過問卷調查、生化抽血檢查以及超音波骨質密度檢測。接著依據變項的性質,進行t檢定、卡方檢定、複迴歸分析、羅吉斯迴歸分析等統計方法,找出骨質疏鬆的危險因子及其與心血管疾病之間的相關性。結果:在本研究中發現男性骨質密度低下(T-score<-1) 之盛行率為48.97%,已停經婦女骨質密度低下之盛行率為52.41%,而未停經婦女骨質密度低下之盛行率為7.14%。若就骨質密度低下與否進行羅吉斯迴歸分析結果發現,就整體而言,骨質密度與男性、已停經女性、年齡、經常吃鈣片呈負相關,而與膽固醇、教育程度呈正相關並達統計上顯著意義(P<0.05);男性而言,骨質密度與每天吃鈣片呈現負相關,而與血中總膽固醇值呈現正相關,並達到統計上顯著之意義(P<0.05);而就女性而言骨質密度與停經、70歲以上、曾因跌倒而骨折等因素呈現負相關;反之與教育程度、飲食中肉類較多、總膽固醇值/高密度膽固醇值比呈正相關,並達到統計上顯著之意義(P<0.05)。而心血管疾病如心肌梗塞、腦中風與骨質密度低下之間並未達到統計上顯著之相關(P>0.05)。結論:心血管疾病如心肌梗塞、腦中風與骨質密度之間並未達到統計上顯著之相關(P>0.05);血中三酸甘油脂、膽固醇較高、膽固醇/高密度膽醇比值均較高的居民的骨質密度較正常,但這些反而是心血管疾病的危險因子。因此在預防心血管疾病與減少骨質疏鬆症發生之間,必需求取一平衡點,以免顧此失彼。關鍵字:骨質疏鬆症、超音波骨密測量儀(QUS) 、心血管疾病、骨質密度

English Abstract

Purpose: Some researches showed there are close relationship between osteoporosis and cardiovascular disease. Only a few researches studied about this topic in Taiwan. The purpose of this study is to understand the prevalence and risk factors of the low bone mineral density. The relationship between bone mineral density and cardiovascular disease will also be evaluated.Method: Using stratified sampling method, this study examines 512 residents older than 50 years in Pu Li township through a questionnaire, biochemical blood test, and QUS examination. We do descriptive analysis, t-test, chi-square test, multiple regression analysis, and logistic regression analysis to find out the risk factor for osteoporosis and the relationship between cardiovascular disease and osteoporosis.Results: The prevalence of lower bone mineral density (T-score<-1) in the male residents is 48.97% and 52.41% in the post-menopause women, but only 7.14% in the pre-menopause women. In logistic regression analysis, for the male residents, this study finds lower bone mineral density is significantly related to taking calcium tablet regularly, and is inversely related to high blood cholesterol level(P<0.05). For the female residents, menopause, over 70 year old, and previous history of fall accident and fracture significantly have lower bone mineral density(P<0.05). On the contrary, female residents with higher education level, more meat in the meal, and higher cholesterol/ HDL ratio significantly have more normal bone mineral density(P<0.05). There are no statistically significant relationship between lower bone mineral density and cardiovascular disease such as myocardial infarction and stroke(P>0.05). Conclusion: There is no statistically significant relationship between lower bone mineral density and cardiovascular disease such as myocardial infarction and stroke (P>0.05) in this study. The residents with higher blood cholesterol level or higher blood cholesterol/high density cholesterol ratio have better bone mineral density, but these factors are the risk factors for the cardiovascular disease. The finding of this study suggests that we need to find a balance between the prevention of cardiovascular disease and oeteoporosis.Key words: Osteoporosis, QUS, cardiovascular disease, bone mineral density

Topic Category 醫藥衛生 > 醫院管理與醫事行政
公共衛生學院 > 醫務管理學系碩士班
社會科學 > 管理學
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