Title

非均勻孔隙率人工支架於側向動脈瘤之流場特性研究

Translated Titles

HASH(0x1a88b430)

Authors

游臣恩

Key Words

動脈瘤 ; 非均勻孔隙率人工支架 ; 血液動力學 ; 質點影像測速儀 ; HASH(0x1a88bf40) ; HASH(0x1a88bfe0) ; HASH(0x1a88c080) ; HASH(0x1a8926a0)

PublicationName

清華大學動力機械工程學系學位論文

Volume or Term/Year and Month of Publication

2008年

Academic Degree Category

碩士

Advisor

劉通敏

Content Language

繁體中文

Chinese Abstract

歷年來腦血管疾病常居國人十大死因的第二名,其中又以顱內動脈瘤破裂為致死主因,目前盛行之治療方法為藉由微細導管將線圈與人工支架置放於動脈瘤開口處,藉以阻礙血液流入動脈瘤內,使瘤內形成血栓,造成瘤體萎縮,來達到治療之目的。先前文獻指出血液動力特性(瘤內流場、壁面剪應力及壓力)與動脈瘤成長破裂過程及血栓形成有重要關係,高剪應力及高血壓會導致動脈瘤成長與破裂,低剪應力區及血流停滯區有助於瘤內血栓形成。目前臨床治療為了引導人工支架穿行於彎曲之腦動脈到達病杜所在位置,而受限於採用低孔隙率(Cα)(較高可繞性或可操作性)之單層腦部人工支架,然而為了加速血栓之形成,已有醫生開始嘗試使用多層人工支架(提高Cα)來治療。究竟適當之人工支架為幾層,臨床上尚無定論,尤有進者,目前文獻多著墨於均勻Cα大小之影響,對於非均勻Cα人工支架之效果的探討甚少,此一事實構成本文研究動機。本文採用非干擾性之視流觀測法、質點影像測速技術及壁壓量測,探討加裝Cα為80%的單層商用Wallstent人工支架後,再分別於瘤體開口處近端1/2區域、遠端1/2區域及近端與遠端各1/4區域局部加裝第二層(Cα=80%)支架,探討此三種局部加密非均勻Cα人工支架對於瘤內血液動力特性之影響。實驗之內頸動脈瘤體模型角度為45°、母管曲率為2.5、生理脈動波形之沃門斯里數為4.0及雷諾數為202∼384。實驗結果以瞬時速度場、瘤內平均速度、壁面剪應力及壓力分佈等來探討,發現在波峰相位下,在近端與遠端加密會導致瘤體內壁所受之剪應力值皆低於易促進血栓形成之臨界低剪應力值(0.5Pa),效果最佳;如就所探討之所有血液動力參數評估,近端與遠端同時加密功效亦最佳、遠端加密次之、近端加密最差。這些發現可供欲採用非均勻性孔隙率人工支架之廠商與醫師參考。

English Abstract

HASH(0x1a8927e0)

Topic Category 工學院 > 動力機械工程學系
工程學 > 機械工程
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