Title

結合專利與臨床研究之整合分析 探討植牙領域之發展趨勢

Translated Titles

Using Patent Analysis and Clinical Trial Analysis to Analyze Dental Implant Technology Development Advancement

Authors

彭馨儀

Key Words

專利分析 ; 本體論 ; 整合分析 ; patent analysis ; ontology ; meta-analysis

PublicationName

清華大學工業工程與工程管理學系學位論文

Volume or Term/Year and Month of Publication

2013年

Academic Degree Category

碩士

Advisor

張瑞芬;張力元

Content Language

繁體中文

Chinese Abstract

科技的進步提高了人類生活的水準,並使人類的生命不斷增長,許多先進國家已進入高齡化的社會環境,因此醫療器材產業不斷的發展,根據相關機構的調查報告顯示,全球的醫療市場將會由2012年的3,000億美金成長至2017年的4,344億美金(Global Information, Inc., 2012),在市場需求的因素驅動下,醫療器材的專利申請數量也不斷上升,根據世界智財組織的資料顯示,在1995年至2008年間,藥學以及醫療科技領域的專利申請成長量相當可觀,僅次於電腦科技、電機與通訊科技類別 (World Intellectual Property Organization, 2011)。專利蘊含了豐富的專業知識與創新價值,但龐大的專利數量與專利文件內的艱深術語,使得專利分析需耗費大量資源,且醫療器材產品的開發過程還須透過臨床試驗才能了解其效用,因此本研究提出結合專利分析與臨床文獻分析的方法,了解未來醫療器材發展的之方向。本研究以專利與臨床文獻的角度分析醫療技術的發展,以知識探勘、本體論、整合分析等方法分析醫療器材專利文件與臨床試驗文獻,本研究首先以文字探勘技術擷取專利文件的重要關鍵字,並建構領域本體論表達專利技術內涵與領域知識,接著分析臨床試驗文獻的關鍵字擴充領域本體論,並進行整合分析了解醫療器材於臨床試驗的效用。本研究以植牙領域為分析案例,希望能了解市場現行發展的趨勢並分析未來可能的市場機會。

English Abstract

The progress of technology increases the average human lifespan. A rise in aging population drives the value of the medical equipment market increases rapidly. According the marketing report, the value of the medical equipment market is US$ 300 billion in 2012, and it is forecasted to reach US$ 430 billion in 2017 (Global Information, Inc., 2012). The rapid growth of medical equipment market indicates that it has great potential for developing. During the period from 1995 to 2008, the volume of patent applications in medical technology increased rapidly worldwide. Computer science, electrical machinery, pharmaceuticals and digital communication also accounted for the large share of total growth (World Intellectual Property Organization, 2011). Patent analysis is useful to understand the trend of technology development. However, the huge volume of patents is hard to analyze effectively and efficiency. In addition, clinical trial on patients must be performed to validate that the new medical equipment is efficacious. The purpose of this study is to analyze emerging medical equipment developments and marketing directions, and a methodology which combines patent analysis with clinical trials is proposed in this study. Knowledge discovering, ontology and meta-analysis are used to extract the useful information from patent documents and clinical trials. This study will use the dental implant technical domain as case study to understand the medical technology market trends.

Topic Category 工學院 > 工業工程與工程管理學系
工程學 > 工程學總論
社會科學 > 管理學
Reference
  1. 1. Annibali, S., Bignozzi, I., Cristalli, M. P., Graziani, F., La Monaca, G., and Polimeni, A. (2012) “Peri-implant marginal bone level: a systematic review and meta-analysis of studies comparing platform switching versus conventionally restored implants,” Journal of clinical periodontology, Volume 39, Issue 11, pp. 1097-1133.
    連結:
  2. 2. APA Publications and Communications Board Working Group on Journal Article Reporting Standards (2008) “Reporting standards for research in psychology: Why do we need them? What might they be?” American Psychologist, Volume 63, Issue 9, pp. 839-851.
    連結:
  3. 3. Atieh, M. A., Ibrahim, H. M., and Atieh, A. H. (2010) “Platform switching for marginal bone preservation around dental implants: a systematic review and meta-analysis.” Journal of Periodontology, Volume 81, Issue 10, pp. 1350-1366.
    連結:
  4. 5. Borenstein, M., Hedges, L., Higgins, J., and Rothstein, H. (2005) Comprehensive Meta-analysis Version 2, Biostat, Englewood NJ.
    連結:
  5. 6. Brandow, R., Mitze, K., Rau, L. F. (1995) “Automatic condensation of electronic publications by sentence selection.” Information Processing & Management, Volume 31, Issue 5, pp. 675-685.
    連結:
  6. 9. Chen, R. (2009) “Design patent map visualization display.” Expert Systems with Applications, Volume 36, Issue 10, pp. 12362–12374.
    連結:
  7. 10. Chen, T. S., Tsai, T. H., Chen, Y. T., Lin, C. C., Chen, R. C., Li, S. Y., Chen, H. Y. (2005) “A combined K-means and hierarchical clustering method for improving the clustering efficiency of microarray.” Proceedings of 2005 International Symposium on Intelligent Signal Processing and Communication Systems, pp. 405-408.
    連結:
  8. 12. Cohen, J. (1988). Statistical Power Analysis for the Behavioral Sciences (2nd Edition), ISBN: 0805802835.
    連結:
  9. 13. Devedzic, V. (2001) "Knowledge Discovery and Data Mining in Databases," Handbook of Software Engineering and Knowledge Engineering, Volume 1, pp. 615-637.
    連結:
  10. 14. Ding, Y. and Foo, S. (2002) “Ontology research and development. Part 1 - a review of ontology generation.” Journal of Information Science, Volume 28, Issue 2, pp. 123-136.
    連結:
  11. 15. Ernst, H. (1995) “Patenting strategies in the German mechanical engineering industry and their relationship to company performance.” Technovation, Volume 15, Issue 4, pp. 225-240.
    連結:
  12. 16. Ernst, H., and Omland, N. (2011) “The Patent Asset Index – A new approach to benchmark patent portfolios.” World Patent Information, Volume 33, Issue 1, March 2011, pp. 34-41.
    連結:
  13. 17. Fayyad, U., Piatetsky-shapiro, G., Smyth, P. (1996) “From Data Mining to Knowledge Discovery in Databases.” AI Magazine, Volume 17, Issue 3, pp. 37-54.
    連結:
  14. 20. Glass, G.V. (1976) “Primary, secondary and meta-analysis of research.” Educational Researcher, Volume 5, Issue 10, pp. 3-8.
    連結:
  15. 22. Gruber, T. (1993) “Toward Principles for the Design of Ontologies Used for Knowledge Sharing.” International Journal Human-Computer Studies, Volume 43, Issue 5-6, pp. 907-928.
    連結:
  16. 27. Hedges, L. V. and Vevea, J. L. (1998) “Fixed- and random-effects models in meta-analysis.” Psychological Methods, Volume 3, Issue 4, pp. 486-504.
    連結:
  17. 28. Huhns, M. N., & Stephens, L. M. (1999). “Personal ontologies.” IEEE Internet Computing, Volume 3, Issue 5, pp. 85-87.
    連結:
  18. 32. Lee, S., Yoon, B., and Park, Y. (2009) “An approach to discovering new technology opportunities: Keyword-based patent map approach.” Technovation, Volume 29, Issue 6-7, pp. 481-497.
    連結:
  19. 33. Luhn, H. P. (1957) “A statistical approach to mechanized encoding and searching of literary information.” IBM Journal of Research and Development, Volume 1, Issue 4, pp. 309-317.
    連結:
  20. 34. Merkl, D. (1998) “Text classification with self-organization maps: Some lessons learned.” Neuro-computing, Volume 21, 1-3, Issue, pp. 61-77.
    連結:
  21. 36. Mori, H., and Kosemura, N. (2002) “A Data Mining Method for Short-Term Load Forecasting in Power Systems.” Electrical Engineering in Japan, Volume 139, Issue 2, pages 12–22.
    連結:
  22. 39. Narin, F. (1994) “Patent bibliometrics.” Scientometrics, Volume 30, Issue 1, pp. 147-155.
    連結:
  23. 40. Narin, F., Noma, E., and Perry, R. (1987) “Narin-Patents as indicators of corporate technological strength.” Research Policy, Volume 16, Issues 2–4, pp. 143-155.
    連結:
  24. 42. Normand, S. T. (1999) “Meta-analysis: formulating, evaluating, combining, and reporting.” Statistics in Medicine, Volume 18, Issue 3, pp. 321-359.
    連結:
  25. 44. Robertson, S. (2004) “Understanding inverse document frequency: On theoretical arguments for IDF.” Journal of Documentation, Volume 60 Issue 5, pp. 503–520.
    連結:
  26. 45. Salton, G., and Buckley C. (1988) “Term-weighting approaches in automatic text retrieval.” Information Processing and Management, Volume 24, Issue 5, pp. 513-523.
    連結:
  27. 46. Salton, G., and Yang, C.S. (1973) "On the specification of term values in automatic indexing", Journal of Documentation, Volume 29 Issue 4, pp. 351-372.
    連結:
  28. 47. Salton, G., Singhal, A., Mitra, M., Buckley, C. (1997) “Automatic text structuring and summarization.” Information Processing & Managemen,t Volume 33, Issue 2, pp. 193-207.
    連結:
  29. 48. Sebastiani, F. (2002) “Machine Learning in Automated Text Categorization.” ACM Computing Surveys, Volume 34, Issue 1, pp. 1-47.
    連結:
  30. 49. Seol, H., Lee, S., Kim, C., (2011) “Identifying new business areas using patent information: A DEA and text mining approach.” Expert Systems with Applications, 37(4), Volume 37, Issue 4, pp. 2933-2941.
    連結:
  31. 50. Shneiderman, B. (1997) “The next generation of graphical user interfaces: information visualization and better window management.” Displays, Volume 17, Issue 34, pp. 125–129.
    連結:
  32. 54. Trappey, A. J. C., Trappey, C. V., Wu, C.-Y., and Lin, C.-W. (2012) “A patent quality analysis for innovative technology and product development.” Advanced Engineering Informatics, Volume 26, Issue 1, pp. 26-34.
    連結:
  33. 55. Trappey, A.J.C., Hsu, F.-C., Trappey, C.V., and Lin, C.-I. (2006) “Development of a patent document classification and search platform using a back-propagation network.” Expert Systems with Applications, Volume 31, Issue 4, pp. 755-765.
    連結:
  34. 56. Tseng, Y.-H., Lin, C.-J., and Lin, Y.-I. (2007) “Text mining techniques for patent analysis.” Information Processing and Management, Volume 43, Issue 5, pp. 1216-1247
    連結:
  35. 57. Uschold, M., Grüninger, M. (1996) “Ontologies: Principles methods and applications.” The Knowledge Engineering Review, Volume 11, Issue 2, pp. 93-155.
    連結:
  36. 59. WIPO (2011). World Intellectual Property Indicators, 2011 edition.
    連結:
  37. 60. WIPO (2012). World Intellectual Property Indicators, 2012 edition
    連結:
  38. 61. Wolf, F. M. (1986) Meta-Analysis: Quantitative Methods for Research Synthesis (Quantitative Applications in the Social Sciences), ISBN: 0803927568.
    連結:
  39. 62. Yoon, B., Yoon, C., Park, Y. (2002) “On the development and application of a self-organizing feature map-based patent map.” R&D Management, Volume 32, Issue 4, pp. 291-300.
    連結:
  40. 63. 余駿 (2006)。「本體論為基之智慧型財產專利文件自動摘要方法論研究」 (指導教授:張瑞芬),碩士論文,國立清華大學,工業工程與工程管理研究所。
    連結:
  41. 66. 林子玄 (2012)。「以資料採礦技術分析LED產業專利訴訟與授權策略」 (指導教授:張瑞芬),碩士論文,國立台北科技大學,工業工程與管理系碩士班。
    連結:
  42. 67. 高志強 (2004)。「組合自動化文件分類技術之研究-以專利文件分類為 例」(指導教授:劉士豪)。碩士論文,中原大學,資訊管理學系。
    連結:
  43. 70. 許芙瑲 (2006)。「智慧專利文件分析-以群集及分類方法為基」 (指導教授:張瑞芬),博士論文,國立清華大學,工業工程與工程管理研究所。
    連結:
  44. 72. 黃盈碩 (2007),「非耗盡分群方法為基之可重疊專利分群方法論研究」 (指導教授:張瑞芬),碩士論文,國立清華大學,工業工程與工程管理研究所。
    連結:
  45. 73. 黃翊軒 (2007)。「本體論為基之智慧型專利文件分類方法論研究」 (指導教授:張瑞芬),碩士論文,國立清華大學,工業工程與工程管理研究所。
    連結:
  46. 74. 楊明穎 (2007) 。「水平平台介面對植體周邊骨嵴之影響」 (指導教授:傅立志),碩士論文,中國醫藥大學,醫學研究所碩士班。
    連結:
  47. 英文文獻
  48. 4. Bateli, M., Att, W., Strub, JR. (2011) “Implant Neck Configurations for Preservation of Marginal Bone Level: a Systematic Review.” The International Journal of Oral & Maxillofacial Implants, Volume 26, Issue 2, pp. 190-303.
  49. 7. Chandrasekaran, B., and Josephson, J .R., and Benjamins, V. R. (1999) “What are ontologies, and why do we need them?” Intelligent Systems and their Applications, IEEE, Volume 14, Issue 1, pp. 20-26.
  50. 8. Chen, M.-S. (1996) “Data mining: an overview from a database perspective.” IEEE Transactions on Knowledge and Data Engineering, Volume 8 , Issue 6, pp. 866-883.
  51. 11. Cimiano, P., Völker J., and Studer R. (2006) “Ontologies on Demand? - A Description of the State-of-the-Art, Applications, Challenges and Trends for Ontology Learning from Text.” Information, Wissenschaft und Praxis, Volume 57, Issue 6-7, pp. 315-320.
  52. 18. Feldman, R. & Dagan, I. (1995) “Knowledge discovery in textual databases (KDT).” In proceedings of the First International Conference on Knowledge Discovery and Data Mining (KDD-95), Montreal, Canada, August 20-21, AAAI Press, 112-117.
  53. 19. Frawley, W. J., Piatetsky-Shapiro, G., and Matheus, C. J. (1992) “Knowledge discovery in databases: an overview.” AI Magazine, Volume 13, Issue 3, pp. 57-70.
  54. 21. Green, S. (2005) “Systematic reviews and meta-analysis.” Singapore Medical Journal, Volume 46, Issue 6, pp. 270-273.
  55. 23. Grüninger ,M., and Fox M. S. (1995) “Methodology for the Design and Evaluation of Ontologies.” International Joint Conference on Artificial Intelligence (IJCAI95), Workshop on Basic Ontological Issues in Knowledge Sharing.
  56. 24. Guarino, N. (1997) “Understanding, building and using ontologies.” International Journal of Human-Computer Studies archive, Volume 46, Issue 2-3, pp. 293-310.
  57. 25. Guarino, N. (1998) “Formal Ontology in Information Systems.” Proceedings of the 1stInternational Conference, Trento, Italy, 6-8. Amsterdam, IOS Press, pp. 3-15.
  58. 26. Guarino, N. (1998). “Some Ontological Principles for Designing Upper Level Lexical Resources.” Proceedings of the First International Conference on Lexical Resources and Evaluation, Granada, Spain, 28-30 May 1998.
  59. 29. Hwang, C. H. (1999). “Incompletely and imprecisely speaking: Using dynamic ontologies for representing and retrieving information.” Proceedings of the 6th International Workshop on Knowledge Representation meets Databases (KRDB'99), Linköping, Sweden, July 29-30, 1999.
  60. 30. Khan, K. S., Kunz, R., Kleijnen, J., and Antes G. (2003) “Five steps to conducting a systematic review.” Journal of the Royal Society of Medicine, Volume 96, Issue 3, pp. 118-121.
  61. 31. Kim, Y. G., Suh, J. H., and Park, S. C. (2008) “Visualization of patent analysis for emerging technology.” Expert Systems with Applications: An International Journal, Volume 34, Issue 3, pp. 1804-1812.
  62. 35. Mooney, R. J. and Nahm, U. Y. (2003) “Text Mining with Information Extraction.” Multilingualism and Electronic Language Management: Proceedings of the 4th International MIDP Colloquium, pp. 141-160.
  63. 37. Morik, K. (2005) “Applications of Knowledge Discovery.” Proceedings of the 18th international conference on Innovations in Applied Artificial Intelligence, pp1-5.
  64. 38. Narang, P., Gupta, H., Arora, A., and Bhandari, A. (2011) “Biomechanics of implant abutment connection: A review.” Indian Journal of Stomatology, Volume 2, Issue 2, pp. 113-116.
  65. 41. Neches, R., Fikes, R.E., Finin, T., Gruber, T.R., Senator, T., and Swartout, W.R. (1991) “Enabling technology for knowledge sharing.” AI Magazine, Volume 12, Issue 3, pp. 36-56.
  66. 43. Ressing, M., Blettner, M., Klug, SJ. (2009) “Systematic Literature Reviews and Meta-Analyses.” Deutsches Ärzteblatt International, Volume 106, Issue 27, pp. 456-463.
  67. 51. Sukanya, M., and Biruntha, S. (2012) “Techniques on text mining.” Proceeding of 2012 IEEE International Conference on Advanced Communication Control and Computing Technologies (ICACCCT), pp. 269-271.
  68. 52. Tan, A. H. (1999) “Text Mining: The state of the art and the challenges.” Proceedings of PAKDD Workshop on Knowledge discovery from Advanced Databases, pp. 71-76.
  69. 53. Theoharidou, A., Petridis, H. P., Tzannas, K., and Garefis, P. (2008) “Abutment screw loosening in single-implant restorations: a systematic review.” The International Journal of Oral and Maxillofacial Implants, Volume 23, Issue 4, pp. 681-690.
  70. 58. WIPO (2006). Inventing the Future - An Introduction to Patents for Small and Medium-sized Enterprises, ISBN: 9280513427.
  71. 中文文獻
  72. 64. 阮明淑、梁峻齊 (2009) 。「專利指標發展研究」,圖書館學與資訊科學,Volume 35, Issue 2, pp.88-106.
  73. 65. 周永杰、林妤珊、邱瑞科(2010)。「以本體為基之糖尿病領域知識檢索系統建立之研究」,2010產業資訊管理學術暨新興科技實務研討會。
  74. 68. 張瑞芬、張力元、吳俊逸與樊晉源(2012)。「專利分析與智慧財產管理」,華泰文化,ISBN:9789576098925。
  75. 69. 戚玉樑 (2005) 。「以本體技術為基礎的知識庫建置程序及其應用」,資訊管理展,Volume 5, Issue 2, pp.1-18。
  76. 71. 曾元顯 (1997),「關鍵詞自動擷取技術與相關詞回饋」,中國圖書館學會會報,Volume 59,pp.59-64。
  77. 75. 經建會人力規劃處 (2010),「2010 年至2060 年台灣人口推計」,台 灣 經 濟 論 衡,Volume 88, Issue 9, pp.66-70。
  78. 76. 劉艾華、王堯天、盧冠廷 (2007)。「以本體技術為基礎的知識庫建置程序及其應用」,資訊科技與社會,Volume 5, Issue 2, pp.1-18。
  79. 77. 蔡潔娃、盧素涵 (2010)。「齒科材料及人工植牙市場分析」,財團法人金屬工業研究發展中心,ISBN:978-986-6519-27-7。
  80. 78. 謝侃呈、陳志達、邱顯光 (2012) 。「一個語意及本體論技術為方法之門診科別推薦系統研製」,2012 資訊教育與科技應用研討會。
  81. 網路文獻
  82. 79. Global Information, Inc. (2012), Available at : http://www.giichinese.com.tw/press/6547.shtml [December 1, 2012]
  83. 80. Higgins, J. P. T. and Green, S. (editors) (2008) Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.0, The Cochrane Collaboration, Available at: from www.cochrane-handbook.org [May 15, 2013]
  84. 81. ITRI, “AvetecLKM.” Available at : http://140.114.54.40:8888/LKM/Others/login.jsp [December 1, 2012]
  85. 82. Morgan Stanley Research Europe. (2012) “Dental Implant Update Between a Rock and a Hard Place - Disruption Is Here” Available at: http://www.implantdirect.com/us/documents/pdf/DENTAL_UPDATE_18_OCT_2012-1.pdf [December 1, 2012].
  86. 83. NCBI (2004) Available at : http://www.ncbi.nlm.nih.gov/About/glance/programs.html [December 1, 2012]
  87. 84. Nobel Biocare Dental Professionals Portal, Available at : http://www.nobelbiocare.com/en/home/default.aspx [December 1, 2012]
  88. 85. Thalheimer, W. and Cook, S. (2002). How to calculate effect sizes from published research articles: A simplified methodology. Available at: http://work-learning.com/effect_sizes.htm [May 15, 2013]
  89. 86. Wheeljet, “IPDSS System.” Available at : http://www.wheeljet.com.tw/IPDSS/Login.aspx [December 1, 2012]
  90. 87. 台灣植體科技股份有限公司,Available at : http://www.titc-dental.com/Implantology.aspx?id=1 [December 1, 2012]
  91. 88. 國家衛生研究院電子報(2007)。「台灣地區國人口腔健康狀況及口腔衛生行為分析--2005年國民健康訪問暨藥物濫用調查結果」,Available at : http://enews.nhri.org.tw/enews_list_new2.php?article_indx=5600&enews_dt=2007-04-04&showx=showarticle&Volume _indx=195 [December 1, 2012]
  92. 89. 經濟部技術處(2011)。「產業技術白皮書」,Available at : http://investtaiwan.nat.gov.tw/doc/itech/2012/2011_2_4_4.pdf [December 1, 2012]
  93. 90. 經濟部智慧財產局(2010),Available at : http://www2.tipo.gov.tw/public/Attachment/322611511928.pdf [December 1, 2012]
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