Title

設計及合成抗「諾羅病毒」之新型「蘇拉明」衍生物

Translated Titles

Design and Synthesis of Suramin Derivatives as New Anti–Noroviral Agents

Authors

蔡沂晉

Key Words

蘇拉明 ; 諾羅病毒 ; NF023 ; 磺酸鈉化合物 ; 硫脲化合物

PublicationName

清華大學化學系所學位論文

Volume or Term/Year and Month of Publication

2013年

Academic Degree Category

碩士

Advisor

胡紀如

Content Language

英文

Chinese Abstract

「諾羅病毒」(Norovirus)是一個27–38 nm的「非包膜病毒」,屬於「杯狀病毒科」(Caliciviridae) 「諾羅病毒屬」(Norovirus),在人類的所有年齡層裡,由「諾羅病毒」所引起之急性腸胃炎極為普遍,在全美爆發的急性腸胃炎大約有50%是由「諾羅病毒」所引起,其中由非細菌所引起的腸胃炎,「諾羅病毒」更占了90%。「諾羅病毒」的傳染力以及發病症狀非常驚人,但目前尚無疫苗可預防也無有效的抗病毒藥物可治療,因此全球對於發展出有效的抗「諾羅病毒」之藥物具急迫性。 本實驗室與義大利「米蘭大學」的Bolognesi 教授團隊合作,設計出有效抗「諾羅病毒」之新型「蘇拉明」衍生物,並利用兩步縮合反應、兩步氫化反應及耦合反應,成功合成出五個新型之「磺酸鈉」衍生物。 藉由核磁共振儀、紅外光光譜儀及高解析質譜儀證實已成功得到「蘇拉明」衍生物,此全合成總共有五個步驟,總產率為46%。並測試其「水溶性」及「脂溶性」,探討其結構對「水溶性」及「脂溶性」的影響,冀其在相同的活性下,能夠更容易進入細胞內,達到提升對抗「諾羅病毒」之更佳效用。

Topic Category 基礎與應用科學 > 化學
理學院 > 化學系所
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