本論文分兩部分。 第一部份討論α-羥基乙酸衍生物的合成研究:本篇研究是以苯醯基甲酸甲酯直接與Grignard試劑(異丙基鎂氯isopropyl magnesium chloride)反應,得到2-羥基-3-甲基-2-苯基丁酸甲酯(methyl 2-hydroxy-3-methyl-2-phenyl butyrate)及苯醯基甲酸甲酯的混合物。將混合物與一級胺反應,純化得到2-羥基-3-甲基-2-苯基丁酸甲酯。此化合物再加以酸化得到2-羥基-3-甲基-2-苯基丁酸。 第二部分討論6-乙氧羰基- 5H-薁併[1,8a,8-c,d]噠秦衍生物合成研究:以3-甲醯基薁-1-羧酸乙酯衍生物,與過量的聯胺及過量的聯胺苯在100℃下反應,得到6-乙氧羰基-5H-薁併[1,8a,8-c,d]噠秦與6-乙氧羰基-1-苯基-4H-薁併[1,8a,8-c,d]噠秦衍生物。並以紅外線光譜儀(IR)、核磁共振光譜儀(NMR)及質譜儀(Mass)鑑定其結構。
Abstract This thesis includes two parts. The first part discusses the synthesis of α-hydroxyl acetic acid derivatives: The reaction of methyl benzoylformate with isopropylmagnesium chloride at 0℃ afforded a mixture of methyl 2-hydroxy-3-methyl-2-phenylburate and methyl benzoylformate, which can not be separated chromatographically. The methyl 2-hydroxy-3-methyl-2-phenylburate was finally purified by addition of primary amine to the reaction mixture to remove methyl benzoylformate. The methyl 2-hydroxy-3-methyl -2-phenylburate was then acidified to give methyl 2-hydroxy-3-methyl-2-phenylburic acid. The second part discusses the synthesis of 6-ethoxycarbonyl-5H- azuleno[1,8a,8-c,d]pyridazine derivatives: The reactions of ethyl 3-formylazulene-1-carboxylate derivatives with excess hydrazine and phenylhydrazine at 100℃ afforded 6-ethoxycarbonyl-5H-azuleno [1,8a,8-c,d]pyridazine and 6-ethoxycarbonyl-1-phenyl-5H-azuleno [1,8a,8-c,d]pyridazine derivatives, respectively. These new compounds were characterized by IR, NMR, Mass spectra.